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Obesity-related hypoferremia is not explained by differences in reported intake of heme and nonheme iron or intake of dietary factors that can affect iron absorption.
J Am Diet Assoc. 2008 Jan; 108(1):145-8.JA

Abstract

Hypoferremia is more prevalent in obese than nonobese adults, but the reason for this phenomenon is unknown. To elucidate the role dietary factors play in obesity-related hypoferremia, the intake of heme and nonheme iron and the intake of other dietary factors known to affect iron absorption were compared cross-sectionally from April 2002 to December 2003 in a convenience sample of 207 obese and 177 nonobese adults. Subjects completed 7-day food records, underwent phlebotomy for serum iron measurement, and had body composition assessed by dual-energy x-ray absorptiometry, during a 21-month period. Data were analyzed by analysis of covariance and multiple linear regression. Serum iron (mean+/-standard deviation) was significantly lower in obese than nonobese individuals (72.0+/-61.7 vs 85.3+/-58.1 microg/dL [12.888+/-11.0443 vs 15.2687+/-10.3999 micromol/L]; P<0.001). The obese cohort reported consuming more animal protein (63.6+/-34.5 vs 55.7+/-32.5 g/day; P<0.001) and more heme iron (3.6+/-2.8 vs 2.7+/-2.6 mg/day; P<0.001). Groups did not differ, however, in total daily iron consumption, including supplements. Obese subjects reported consuming less vitamin C (77.2+/-94.9 vs 91.8+/-89.5 mg/day; P=0.01), which may increase absorption of nonheme iron, and less calcium (766.2+/-665.0 vs 849.0+/-627.2 mg/day; P=0.038), which may decrease nonheme iron absorption, than nonobese subjects. Groups did not significantly differ in intake of other dietary factors that can impact absorption of iron, including phytic acid, oxalic acid, eggs, coffee, tea, zinc, vegetable protein, or copper. After accounting for demographic covariates and dietary factors expected to affect iron absorption, fat mass (P=0.007) remained a statistically significant negative predictor of serum iron. This cross-sectional, exploratory study suggests that obesity-related hypoferremia is not associated with differences in reported intake of heme and nonheme iron or intake of dietary factors that can affect iron absorption.

Authors+Show Affiliations

Unit on Growth and Obesity, National Institutes of Health, Hatfield Clinical Research Center, Bethesda, MD 20892-1103, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

18156002

Citation

Menzie, Carolyn M., et al. "Obesity-related Hypoferremia Is Not Explained By Differences in Reported Intake of Heme and Nonheme Iron or Intake of Dietary Factors That Can Affect Iron Absorption." Journal of the American Dietetic Association, vol. 108, no. 1, 2008, pp. 145-8.
Menzie CM, Yanoff LB, Denkinger BI, et al. Obesity-related hypoferremia is not explained by differences in reported intake of heme and nonheme iron or intake of dietary factors that can affect iron absorption. J Am Diet Assoc. 2008;108(1):145-8.
Menzie, C. M., Yanoff, L. B., Denkinger, B. I., McHugh, T., Sebring, N. G., Calis, K. A., & Yanovski, J. A. (2008). Obesity-related hypoferremia is not explained by differences in reported intake of heme and nonheme iron or intake of dietary factors that can affect iron absorption. Journal of the American Dietetic Association, 108(1), 145-8.
Menzie CM, et al. Obesity-related Hypoferremia Is Not Explained By Differences in Reported Intake of Heme and Nonheme Iron or Intake of Dietary Factors That Can Affect Iron Absorption. J Am Diet Assoc. 2008;108(1):145-8. PubMed PMID: 18156002.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Obesity-related hypoferremia is not explained by differences in reported intake of heme and nonheme iron or intake of dietary factors that can affect iron absorption. AU - Menzie,Carolyn M, AU - Yanoff,Lisa B, AU - Denkinger,Blakeley I, AU - McHugh,Teresa, AU - Sebring,Nancy G, AU - Calis,Karim A, AU - Yanovski,Jack A, PY - 2007/12/25/pubmed PY - 2008/2/20/medline PY - 2007/12/25/entrez SP - 145 EP - 8 JF - Journal of the American Dietetic Association JO - J Am Diet Assoc VL - 108 IS - 1 N2 - Hypoferremia is more prevalent in obese than nonobese adults, but the reason for this phenomenon is unknown. To elucidate the role dietary factors play in obesity-related hypoferremia, the intake of heme and nonheme iron and the intake of other dietary factors known to affect iron absorption were compared cross-sectionally from April 2002 to December 2003 in a convenience sample of 207 obese and 177 nonobese adults. Subjects completed 7-day food records, underwent phlebotomy for serum iron measurement, and had body composition assessed by dual-energy x-ray absorptiometry, during a 21-month period. Data were analyzed by analysis of covariance and multiple linear regression. Serum iron (mean+/-standard deviation) was significantly lower in obese than nonobese individuals (72.0+/-61.7 vs 85.3+/-58.1 microg/dL [12.888+/-11.0443 vs 15.2687+/-10.3999 micromol/L]; P<0.001). The obese cohort reported consuming more animal protein (63.6+/-34.5 vs 55.7+/-32.5 g/day; P<0.001) and more heme iron (3.6+/-2.8 vs 2.7+/-2.6 mg/day; P<0.001). Groups did not differ, however, in total daily iron consumption, including supplements. Obese subjects reported consuming less vitamin C (77.2+/-94.9 vs 91.8+/-89.5 mg/day; P=0.01), which may increase absorption of nonheme iron, and less calcium (766.2+/-665.0 vs 849.0+/-627.2 mg/day; P=0.038), which may decrease nonheme iron absorption, than nonobese subjects. Groups did not significantly differ in intake of other dietary factors that can impact absorption of iron, including phytic acid, oxalic acid, eggs, coffee, tea, zinc, vegetable protein, or copper. After accounting for demographic covariates and dietary factors expected to affect iron absorption, fat mass (P=0.007) remained a statistically significant negative predictor of serum iron. This cross-sectional, exploratory study suggests that obesity-related hypoferremia is not associated with differences in reported intake of heme and nonheme iron or intake of dietary factors that can affect iron absorption. SN - 0002-8223 UR - https://www.unboundmedicine.com/medline/citation/18156002/Obesity_related_hypoferremia_is_not_explained_by_differences_in_reported_intake_of_heme_and_nonheme_iron_or_intake_of_dietary_factors_that_can_affect_iron_absorption_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-8223(07)02037-8 DB - PRIME DP - Unbound Medicine ER -