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Long-chain saturated fatty acids consumption and risk of gallstone disease among men.

Abstract

BACKGROUND

Various saturated fatty acids have different effects on blood lipids and insulin secretion in experiments. The effect of long-term consumption of specific and different classes of saturated fatty acids on the risk of gallstone disease in humans is unknown.

METHODS

We prospectively studied consumption of saturated fatty acids and risk of gallstone disease in a cohort of 44,524 US men from 1986 to 2002. Intake of saturated fatty acids was assessed using a validated semiquantitative food frequency questionnaire. Newly diagnosed gallstone disease was ascertained biennially.

RESULTS

During 584,679 person-years of follow-up, we documented 2350 incident cases of gallstone disease, of which 1387 cases required cholecystectomy. Compared with men in the lowest quintile of dietary intake of long-chain saturated fats, after adjustment for age and other potential risk factors, the relative risk of gallstone disease for men in the highest quintile was 1.24 [95% confidence interval (CI), 1.02, 1.50, P for trend = 0.03], and the relative risk of cholecystectomy for men in the highest quintile was 1.41 (CI, 1.09, 1.82, P for trend = 0.008). Consumption of medium-chain saturated fatty acids or short-chain saturated fatty acids was unrelated to the risk.

CONCLUSIONS

Our results suggest that a higher consumption of long-chain saturated fatty acids may enhance the risk of gallstone disease in men.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Division of Digestive Diseases and Nutrition, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536, USA. hpcjt@channing.harvard.edu

    , ,

    Source

    Annals of surgery 247:1 2008 Jan pg 95-103

    MeSH

    Diet
    Diet Surveys
    Fatty Acids
    Gallstones
    Humans
    Incidence
    Male
    Middle Aged
    Proportional Hazards Models
    Prospective Studies
    Risk Factors
    United States

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    18156928

    Citation

    Tsai, Chung-Jyi, et al. "Long-chain Saturated Fatty Acids Consumption and Risk of Gallstone Disease Among Men." Annals of Surgery, vol. 247, no. 1, 2008, pp. 95-103.
    Tsai CJ, Leitzmann MF, Willett WC, et al. Long-chain saturated fatty acids consumption and risk of gallstone disease among men. Ann Surg. 2008;247(1):95-103.
    Tsai, C. J., Leitzmann, M. F., Willett, W. C., & Giovannucci, E. L. (2008). Long-chain saturated fatty acids consumption and risk of gallstone disease among men. Annals of Surgery, 247(1), pp. 95-103.
    Tsai CJ, et al. Long-chain Saturated Fatty Acids Consumption and Risk of Gallstone Disease Among Men. Ann Surg. 2008;247(1):95-103. PubMed PMID: 18156928.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Long-chain saturated fatty acids consumption and risk of gallstone disease among men. AU - Tsai,Chung-Jyi, AU - Leitzmann,Michael F, AU - Willett,Walter C, AU - Giovannucci,Edward L, PY - 2007/12/25/pubmed PY - 2008/2/22/medline PY - 2007/12/25/entrez SP - 95 EP - 103 JF - Annals of surgery JO - Ann. Surg. VL - 247 IS - 1 N2 - BACKGROUND: Various saturated fatty acids have different effects on blood lipids and insulin secretion in experiments. The effect of long-term consumption of specific and different classes of saturated fatty acids on the risk of gallstone disease in humans is unknown. METHODS: We prospectively studied consumption of saturated fatty acids and risk of gallstone disease in a cohort of 44,524 US men from 1986 to 2002. Intake of saturated fatty acids was assessed using a validated semiquantitative food frequency questionnaire. Newly diagnosed gallstone disease was ascertained biennially. RESULTS: During 584,679 person-years of follow-up, we documented 2350 incident cases of gallstone disease, of which 1387 cases required cholecystectomy. Compared with men in the lowest quintile of dietary intake of long-chain saturated fats, after adjustment for age and other potential risk factors, the relative risk of gallstone disease for men in the highest quintile was 1.24 [95% confidence interval (CI), 1.02, 1.50, P for trend = 0.03], and the relative risk of cholecystectomy for men in the highest quintile was 1.41 (CI, 1.09, 1.82, P for trend = 0.008). Consumption of medium-chain saturated fatty acids or short-chain saturated fatty acids was unrelated to the risk. CONCLUSIONS: Our results suggest that a higher consumption of long-chain saturated fatty acids may enhance the risk of gallstone disease in men. SN - 0003-4932 UR - https://www.unboundmedicine.com/medline/citation/18156928/Long_chain_saturated_fatty_acids_consumption_and_risk_of_gallstone_disease_among_men_ L2 - http://Insights.ovid.com/pubmed?pmid=18156928 DB - PRIME DP - Unbound Medicine ER -