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Human leukocyte antigen-G expression after kidney transplantation is associated with a reduced incidence of rejection.
Transpl Immunol. 2008 Feb; 18(4):361-7.TI

Abstract

HLA-G is a non-classic Human Leukocyte Antigen (HLA-G) Class I of low polymorphism and restricted tissue distribution that displays tolerogenic functions. In heart transplantation and in combined liver/renal allograft transplantation, the expression of HLA-G has been associated with a lower incidence of acute graft rejection episodes and absence of chronic dysfunction. Since the expression of HLA-G in renal biopsies has been investigated only in few patients who received a combined kidney and liver transplant, in this study we performed a cross-sectional study, systematically comparing the expression of HLA-G in post-transplanted renal grafts, stratifying patients according to the presence or absence of rejection.

PATIENTS AND METHODS

Seventy-three renal specimens (10 with acute rejection and 13 with chronic allograft nephropathy, and 50 with no signs of rejection) were immunohistochemically evaluated for HLA-G expression.

RESULTS

In the group as a whole, HLA-G molecules were detected in 40 cases (54.8%). Among specimens that presented HLA-G expression, 2 out of 40 (5%) exhibited acute rejection, 2 (5%) exhibited chronic allograft nephropathy, and the remaining 36 (90%) exhibited no signs of rejection. The comparison between patients with rejection and those without rejection showed that the expression of HLA-G was significantly increased in specimens exhibiting no signs of rejection (p<0.0001). Considering only patients with acute rejection, 8 out of 10 patients showed no HLA-G expression in their kidney biopsies when compared to patients exhibiting no signs of rejection and absence of HLA-G was observed in 14 out of 50 (p=0.0032). Similarly, considering only patients with chronic allograft nephropathy, absence of HLA-G expression was observed in 11 out of 13 specimens, whereas in patients without rejection absence of HLA-G was observed in 14 out of 50 (p=0.003). Therapy with tacrolimus was significantly associated with the expression of HLA-G and a better graft prognosis.

CONCLUSIONS

Our results suggest that HLA-G expression in the kidney allograft and the use of tacrolimus are associated with a lower frequency of acute renal rejection and chronic allograft nephropathy.

Authors+Show Affiliations

Department of Biochemistry and Immunology, FMRP-USP, Brazil. janacrispim@usp.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18158124

Citation

Crispim, J C O., et al. "Human Leukocyte antigen-G Expression After Kidney Transplantation Is Associated With a Reduced Incidence of Rejection." Transplant Immunology, vol. 18, no. 4, 2008, pp. 361-7.
Crispim JC, Duarte RA, Soares CP, et al. Human leukocyte antigen-G expression after kidney transplantation is associated with a reduced incidence of rejection. Transpl Immunol. 2008;18(4):361-7.
Crispim, J. C., Duarte, R. A., Soares, C. P., Costa, R., Silva, J. S., Mendes-Júnior, C. T., Wastowski, I. J., Faggioni, L. P., Saber, L. T., & Donadi, E. A. (2008). Human leukocyte antigen-G expression after kidney transplantation is associated with a reduced incidence of rejection. Transplant Immunology, 18(4), 361-7.
Crispim JC, et al. Human Leukocyte antigen-G Expression After Kidney Transplantation Is Associated With a Reduced Incidence of Rejection. Transpl Immunol. 2008;18(4):361-7. PubMed PMID: 18158124.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human leukocyte antigen-G expression after kidney transplantation is associated with a reduced incidence of rejection. AU - Crispim,J C O, AU - Duarte,R A, AU - Soares,C P, AU - Costa,R, AU - Silva,J S, AU - Mendes-Júnior,C T, AU - Wastowski,I J, AU - Faggioni,L P, AU - Saber,L T, AU - Donadi,E A, Y1 - 2007/11/26/ PY - 2007/07/12/received PY - 2007/10/09/revised PY - 2007/10/25/accepted PY - 2007/12/26/pubmed PY - 2008/4/24/medline PY - 2007/12/26/entrez SP - 361 EP - 7 JF - Transplant immunology JO - Transpl. Immunol. VL - 18 IS - 4 N2 - UNLABELLED: HLA-G is a non-classic Human Leukocyte Antigen (HLA-G) Class I of low polymorphism and restricted tissue distribution that displays tolerogenic functions. In heart transplantation and in combined liver/renal allograft transplantation, the expression of HLA-G has been associated with a lower incidence of acute graft rejection episodes and absence of chronic dysfunction. Since the expression of HLA-G in renal biopsies has been investigated only in few patients who received a combined kidney and liver transplant, in this study we performed a cross-sectional study, systematically comparing the expression of HLA-G in post-transplanted renal grafts, stratifying patients according to the presence or absence of rejection. PATIENTS AND METHODS: Seventy-three renal specimens (10 with acute rejection and 13 with chronic allograft nephropathy, and 50 with no signs of rejection) were immunohistochemically evaluated for HLA-G expression. RESULTS: In the group as a whole, HLA-G molecules were detected in 40 cases (54.8%). Among specimens that presented HLA-G expression, 2 out of 40 (5%) exhibited acute rejection, 2 (5%) exhibited chronic allograft nephropathy, and the remaining 36 (90%) exhibited no signs of rejection. The comparison between patients with rejection and those without rejection showed that the expression of HLA-G was significantly increased in specimens exhibiting no signs of rejection (p<0.0001). Considering only patients with acute rejection, 8 out of 10 patients showed no HLA-G expression in their kidney biopsies when compared to patients exhibiting no signs of rejection and absence of HLA-G was observed in 14 out of 50 (p=0.0032). Similarly, considering only patients with chronic allograft nephropathy, absence of HLA-G expression was observed in 11 out of 13 specimens, whereas in patients without rejection absence of HLA-G was observed in 14 out of 50 (p=0.003). Therapy with tacrolimus was significantly associated with the expression of HLA-G and a better graft prognosis. CONCLUSIONS: Our results suggest that HLA-G expression in the kidney allograft and the use of tacrolimus are associated with a lower frequency of acute renal rejection and chronic allograft nephropathy. SN - 0966-3274 UR - https://www.unboundmedicine.com/medline/citation/18158124/Human_leukocyte_antigen_G_expression_after_kidney_transplantation_is_associated_with_a_reduced_incidence_of_rejection_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0966-3274(07)00182-7 DB - PRIME DP - Unbound Medicine ER -