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Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma.
J Cell Biol. 2007 Dec 31; 179(7):1523-37.JC

Abstract

Here, we use a mouse model (DBA/2J) to readdress the location of insult(s) to retinal ganglion cells (RGCs) in glaucoma. We localize an early sign of axon damage to an astrocyte-rich region of the optic nerve just posterior to the retina, analogous to the lamina cribrosa. In this region, a network of astrocytes associates intimately with RGC axons. Using BAX-deficient DBA/2J mice, which retain all of their RGCs, we provide experimental evidence for an insult within or very close to the lamina in the optic nerve. We show that proximal axon segments attached to their cell bodies survive to the proximity of the lamina. In contrast, axon segments in the lamina and behind the eye degenerate. Finally, the Wld(s) allele, which is known to protect against insults to axons, strongly protects against DBA/2J glaucoma and preserves RGC activity as measured by pattern electroretinography. These experiments provide strong evidence for a local insult to axons in the optic nerve.

Authors+Show Affiliations

The Jackson Laboratory, Bar Harbor, ME 04609, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18158332

Citation

Howell, Gareth R., et al. "Axons of Retinal Ganglion Cells Are Insulted in the Optic Nerve Early in DBA/2J Glaucoma." The Journal of Cell Biology, vol. 179, no. 7, 2007, pp. 1523-37.
Howell GR, Libby RT, Jakobs TC, et al. Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma. J Cell Biol. 2007;179(7):1523-37.
Howell, G. R., Libby, R. T., Jakobs, T. C., Smith, R. S., Phalan, F. C., Barter, J. W., Barbay, J. M., Marchant, J. K., Mahesh, N., Porciatti, V., Whitmore, A. V., Masland, R. H., & John, S. W. (2007). Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma. The Journal of Cell Biology, 179(7), 1523-37.
Howell GR, et al. Axons of Retinal Ganglion Cells Are Insulted in the Optic Nerve Early in DBA/2J Glaucoma. J Cell Biol. 2007 Dec 31;179(7):1523-37. PubMed PMID: 18158332.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma. AU - Howell,Gareth R, AU - Libby,Richard T, AU - Jakobs,Tatjana C, AU - Smith,Richard S, AU - Phalan,F Campbell, AU - Barter,Joseph W, AU - Barbay,Jessica M, AU - Marchant,Jeffrey K, AU - Mahesh,Nagaraju, AU - Porciatti,Vittorio, AU - Whitmore,Alan V, AU - Masland,Richard H, AU - John,Simon W M, Y1 - 2007/12/24/ PY - 2007/12/26/pubmed PY - 2008/2/26/medline PY - 2007/12/26/entrez SP - 1523 EP - 37 JF - The Journal of cell biology JO - J Cell Biol VL - 179 IS - 7 N2 - Here, we use a mouse model (DBA/2J) to readdress the location of insult(s) to retinal ganglion cells (RGCs) in glaucoma. We localize an early sign of axon damage to an astrocyte-rich region of the optic nerve just posterior to the retina, analogous to the lamina cribrosa. In this region, a network of astrocytes associates intimately with RGC axons. Using BAX-deficient DBA/2J mice, which retain all of their RGCs, we provide experimental evidence for an insult within or very close to the lamina in the optic nerve. We show that proximal axon segments attached to their cell bodies survive to the proximity of the lamina. In contrast, axon segments in the lamina and behind the eye degenerate. Finally, the Wld(s) allele, which is known to protect against insults to axons, strongly protects against DBA/2J glaucoma and preserves RGC activity as measured by pattern electroretinography. These experiments provide strong evidence for a local insult to axons in the optic nerve. SN - 1540-8140 UR - https://www.unboundmedicine.com/medline/citation/18158332/Axons_of_retinal_ganglion_cells_are_insulted_in_the_optic_nerve_early_in_DBA/2J_glaucoma_ L2 - https://rupress.org/jcb/article-lookup/doi/10.1083/jcb.200706181 DB - PRIME DP - Unbound Medicine ER -