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Admission glycaemia and outcome in patients with acute coronary syndrome.
Diab Vasc Dis Res. 2007 Dec; 4(4):346-52.DV

Abstract

Some studies of patients with acute myocardial infarction have reported that hyperglycaemia at admission may be associated with a worse outcome. This study sought to evaluate the association of blood glucose at admission with the outcome of unselected patients with acute coronary syndrome (ACS). Using the Acute Myocardial Infarction and unstable angina in Switzerland (AMIS Plus) registry, ACS patients were stratified according to their blood glucose on admission: group 1: 2.80-6.99 mmol/L, group 2: 7.00-11.09 mmol/L and group 3: > 11.10 mmol/L. Odds ratios for in-hospital mortality were calculated using logistic regression models. Of 2,786 patients, 73% were male and 21% were known to have diabetes. In-hospital mortality increased from 3% in group 1 to 7% in group 2 and to 15% in group 3. Higher glucose levels were associated with larger enzymatic infarct sizes (p<0.001) and had a weak negative correlation with angiographic or echographic left ventricular ejection fraction. High admission glycaemia in ACS patients remains a significant independent predictor of in-hospital mortality (adjusted OR 1.08; 95% confidence intervals [CI] 1.05-1.14, p<0.001) per mmol/L. The OR for in-hospital mortality was 1.04 (95% CI 0.99-1.1; p=0.140) per mmol/L for patients with diabetes but 1.21 (95% CI 112-1.30; p<0.001) per mmol/L for non-diabetic patients. In conclusion, elevated glucose level in ACS patients on admission is a significant independent predictor of in-hospital mortality and is even more important for patients who do not have known diabetes.

Authors+Show Affiliations

Acute myocardial infarction and unstable angina in Switzerland (AMIS Plus) Data Center, Institute of Social and Preventive Medicine, University of Zurich, Zurich, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18158706

Citation

Müdespacher, Damaris, et al. "Admission Glycaemia and Outcome in Patients With Acute Coronary Syndrome." Diabetes & Vascular Disease Research, vol. 4, no. 4, 2007, pp. 346-52.
Müdespacher D, Radovanovic D, Camenzind E, et al. Admission glycaemia and outcome in patients with acute coronary syndrome. Diab Vasc Dis Res. 2007;4(4):346-52.
Müdespacher, D., Radovanovic, D., Camenzind, E., Essig, M., Bertel, O., Erne, P., Eberli, F. R., & Gutzwiller, F. (2007). Admission glycaemia and outcome in patients with acute coronary syndrome. Diabetes & Vascular Disease Research, 4(4), 346-52.
Müdespacher D, et al. Admission Glycaemia and Outcome in Patients With Acute Coronary Syndrome. Diab Vasc Dis Res. 2007;4(4):346-52. PubMed PMID: 18158706.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Admission glycaemia and outcome in patients with acute coronary syndrome. AU - Müdespacher,Damaris, AU - Radovanovic,Dragana, AU - Camenzind,Edoardo, AU - Essig,Manfred, AU - Bertel,Osmund, AU - Erne,Paul, AU - Eberli,Franz Robert, AU - Gutzwiller,Felix, AU - ,, PY - 2007/12/26/pubmed PY - 2008/2/13/medline PY - 2007/12/26/entrez SP - 346 EP - 52 JF - Diabetes & vascular disease research JO - Diab Vasc Dis Res VL - 4 IS - 4 N2 - Some studies of patients with acute myocardial infarction have reported that hyperglycaemia at admission may be associated with a worse outcome. This study sought to evaluate the association of blood glucose at admission with the outcome of unselected patients with acute coronary syndrome (ACS). Using the Acute Myocardial Infarction and unstable angina in Switzerland (AMIS Plus) registry, ACS patients were stratified according to their blood glucose on admission: group 1: 2.80-6.99 mmol/L, group 2: 7.00-11.09 mmol/L and group 3: > 11.10 mmol/L. Odds ratios for in-hospital mortality were calculated using logistic regression models. Of 2,786 patients, 73% were male and 21% were known to have diabetes. In-hospital mortality increased from 3% in group 1 to 7% in group 2 and to 15% in group 3. Higher glucose levels were associated with larger enzymatic infarct sizes (p<0.001) and had a weak negative correlation with angiographic or echographic left ventricular ejection fraction. High admission glycaemia in ACS patients remains a significant independent predictor of in-hospital mortality (adjusted OR 1.08; 95% confidence intervals [CI] 1.05-1.14, p<0.001) per mmol/L. The OR for in-hospital mortality was 1.04 (95% CI 0.99-1.1; p=0.140) per mmol/L for patients with diabetes but 1.21 (95% CI 112-1.30; p<0.001) per mmol/L for non-diabetic patients. In conclusion, elevated glucose level in ACS patients on admission is a significant independent predictor of in-hospital mortality and is even more important for patients who do not have known diabetes. SN - 1479-1641 UR - https://www.unboundmedicine.com/medline/citation/18158706/Admission_glycaemia_and_outcome_in_patients_with_acute_coronary_syndrome_ L2 - http://journals.sagepub.com/doi/full/10.3132/dvdr.2007.063?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -