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Distribution of zinc, copper and iron in biological samples of Pakistani myocardial infarction (1st, 2nd and 3rd heart attack) patients and controls.
Clin Chim Acta 2008; 389(1-2):114-9CC

Abstract

BACKGROUND

The pathogenesis of some heart diseases has been associated with changes in the balance of certain trace elements. We examined the association of iron, copper and zinc between biological samples (scalp hair, whole blood and urine) and mortality from myocardial infarction (MI) patients of (first, second and third heart attack).

METHODS

The biological samples were from 130 MI patients (77 male and 53 female, age range 45-60 years) and 61 healthy age-matched controls (33 male and 28 female). The metals in the biological samples were measured by the flame atomic absorption spectrophotometry, prior to microwave assisted acid digestion. The validity of the methodology was checked by the biological certified reference materials.

RESULTS

During this study, 78% of the 32 patients aged >50 years, registered after the third MI attack died. In these subjects the concentration of Fe and Cu were increased by 0.83% and 3.12% in the scalp hair while in blood samples 9.7% and 22.5% were enhanced respectively, as compared to those who tolerated 3rd MI attack (p=0.072). The concentrations of Zn in whole blood and scalp hair samples were lower in MI patients as compared to normal subjects.

CONCLUSION

Deficiency of zinc and high concentration of copper and iron may play a role in the development of heart disease.

Authors+Show Affiliations

National Centre of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, Pakistan. tgkazi@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Validation Studies

Language

eng

PubMed ID

18158921

Citation

Kazi, Tasneem Gul, et al. "Distribution of Zinc, Copper and Iron in Biological Samples of Pakistani Myocardial Infarction (1st, 2nd and 3rd Heart Attack) Patients and Controls." Clinica Chimica Acta; International Journal of Clinical Chemistry, vol. 389, no. 1-2, 2008, pp. 114-9.
Kazi TG, Afridi HI, Kazi N, et al. Distribution of zinc, copper and iron in biological samples of Pakistani myocardial infarction (1st, 2nd and 3rd heart attack) patients and controls. Clin Chim Acta. 2008;389(1-2):114-9.
Kazi, T. G., Afridi, H. I., Kazi, N., Jamali, M. K., Arain, M. B., Sarfraz, R. A., ... Khandhro, G. A. (2008). Distribution of zinc, copper and iron in biological samples of Pakistani myocardial infarction (1st, 2nd and 3rd heart attack) patients and controls. Clinica Chimica Acta; International Journal of Clinical Chemistry, 389(1-2), pp. 114-9.
Kazi TG, et al. Distribution of Zinc, Copper and Iron in Biological Samples of Pakistani Myocardial Infarction (1st, 2nd and 3rd Heart Attack) Patients and Controls. Clin Chim Acta. 2008;389(1-2):114-9. PubMed PMID: 18158921.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Distribution of zinc, copper and iron in biological samples of Pakistani myocardial infarction (1st, 2nd and 3rd heart attack) patients and controls. AU - Kazi,Tasneem Gul, AU - Afridi,Hassan Imran, AU - Kazi,Naveed, AU - Jamali,Mohammad Khan, AU - Arain,Mohammad Bilal, AU - Sarfraz,Raja Adil, AU - Jalbani,Nusrat, AU - Ansari,Rehana, AU - Shah,Abdul Qadir, AU - Memon,Ateeq-Ur-Rehman, AU - Khandhro,Ghulam Abbass, Y1 - 2007/12/14/ PY - 2007/09/29/received PY - 2007/12/01/revised PY - 2007/12/03/accepted PY - 2007/12/27/pubmed PY - 2008/5/6/medline PY - 2007/12/27/entrez SP - 114 EP - 9 JF - Clinica chimica acta; international journal of clinical chemistry JO - Clin. Chim. Acta VL - 389 IS - 1-2 N2 - BACKGROUND: The pathogenesis of some heart diseases has been associated with changes in the balance of certain trace elements. We examined the association of iron, copper and zinc between biological samples (scalp hair, whole blood and urine) and mortality from myocardial infarction (MI) patients of (first, second and third heart attack). METHODS: The biological samples were from 130 MI patients (77 male and 53 female, age range 45-60 years) and 61 healthy age-matched controls (33 male and 28 female). The metals in the biological samples were measured by the flame atomic absorption spectrophotometry, prior to microwave assisted acid digestion. The validity of the methodology was checked by the biological certified reference materials. RESULTS: During this study, 78% of the 32 patients aged >50 years, registered after the third MI attack died. In these subjects the concentration of Fe and Cu were increased by 0.83% and 3.12% in the scalp hair while in blood samples 9.7% and 22.5% were enhanced respectively, as compared to those who tolerated 3rd MI attack (p=0.072). The concentrations of Zn in whole blood and scalp hair samples were lower in MI patients as compared to normal subjects. CONCLUSION: Deficiency of zinc and high concentration of copper and iron may play a role in the development of heart disease. SN - 0009-8981 UR - https://www.unboundmedicine.com/medline/citation/18158921/Distribution_of_zinc_copper_and_iron_in_biological_samples_of_Pakistani_myocardial_infarction__1st_2nd_and_3rd_heart_attack__patients_and_controls_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-8981(07)00591-8 DB - PRIME DP - Unbound Medicine ER -