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Idiopathic central precocious puberty in 28 boys.
Med Sci Monit. 2008 Jan; 14(1):CR10-14.MS

Abstract

BACKGROUND

Idiopathic central precocious puberty (CPP) is rare in boys. The aim was to to analyze the presentation and evaluate the frequency of familial factor in boys with idiopathic CPP.

MATERIAL/METHODS

Data for 28 boys seen consecutively by the same physician for idiopathic CPP were analyzed.

RESULTS

Puberty started after seven years in all the boys. The associations were intrauterine growth retardation in two, one of whom had Silver Russell syndrome, bilateral retinal degeneration (one case), epilepsy (one case), cryptorchidism (two cases), and inguinal hernia (two cases). All patients had normal basal plasma concentrations of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). The LH/FSH peaks ratio after a gonadotropin hormone-releasing hormone (GnRH) test was <2 in 8/26 and plasma testosterone <0.5 ng/ml in 5/28. Familial early puberty was found in 12 cases (40%). Familial and non-familial forms had similar characteristics, except that body mass index was greater in the familial form (P<0.04). Plasma testosterone of one patient, whose mother had menstruated at 11 years, remained >1 ng/ml despite shortening the interval between GnRH analogue injections.

CONCLUSIONS

Puberty started after seven years in all cases of idiopathic CPP, suggesting that pubertal onset before this age suggests organic CPP. Almost half the cases had familial early puberty.

Authors+Show Affiliations

University Paris-Descartes, Assistance Publique-Hopitaux de Paris, Hopital Bicetre, Pediatric Endocrinology Unit, Paris, France.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18160938

Citation

Pigneur, Bénédicte, et al. "Idiopathic Central Precocious Puberty in 28 Boys." Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, vol. 14, no. 1, 2008, pp. CR10-14.
Pigneur B, Trivin C, Brauner R. Idiopathic central precocious puberty in 28 boys. Med Sci Monit. 2008;14(1):CR10-14.
Pigneur, B., Trivin, C., & Brauner, R. (2008). Idiopathic central precocious puberty in 28 boys. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 14(1), CR10-14.
Pigneur B, Trivin C, Brauner R. Idiopathic Central Precocious Puberty in 28 Boys. Med Sci Monit. 2008;14(1):CR10-14. PubMed PMID: 18160938.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Idiopathic central precocious puberty in 28 boys. AU - Pigneur,Bénédicte, AU - Trivin,Christine, AU - Brauner,Raja, PY - 2007/12/28/pubmed PY - 2008/4/18/medline PY - 2007/12/28/entrez SP - CR10 EP - 14 JF - Medical science monitor : international medical journal of experimental and clinical research JO - Med. Sci. Monit. VL - 14 IS - 1 N2 - BACKGROUND: Idiopathic central precocious puberty (CPP) is rare in boys. The aim was to to analyze the presentation and evaluate the frequency of familial factor in boys with idiopathic CPP. MATERIAL/METHODS: Data for 28 boys seen consecutively by the same physician for idiopathic CPP were analyzed. RESULTS: Puberty started after seven years in all the boys. The associations were intrauterine growth retardation in two, one of whom had Silver Russell syndrome, bilateral retinal degeneration (one case), epilepsy (one case), cryptorchidism (two cases), and inguinal hernia (two cases). All patients had normal basal plasma concentrations of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). The LH/FSH peaks ratio after a gonadotropin hormone-releasing hormone (GnRH) test was <2 in 8/26 and plasma testosterone <0.5 ng/ml in 5/28. Familial early puberty was found in 12 cases (40%). Familial and non-familial forms had similar characteristics, except that body mass index was greater in the familial form (P<0.04). Plasma testosterone of one patient, whose mother had menstruated at 11 years, remained >1 ng/ml despite shortening the interval between GnRH analogue injections. CONCLUSIONS: Puberty started after seven years in all cases of idiopathic CPP, suggesting that pubertal onset before this age suggests organic CPP. Almost half the cases had familial early puberty. SN - 1234-1010 UR - https://www.unboundmedicine.com/medline/citation/18160938/Idiopathic_central_precocious_puberty_in_28_boys_ L2 - https://www.medscimonit.com/download/index/idArt/636054 DB - PRIME DP - Unbound Medicine ER -