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Sensitive chiral analysis by CE: an update.
Electrophoresis. 2008 Jan; 29(1):237-51.E

Abstract

A general view of the different strategies used in the last years to enhance the detection sensitivity in chiral analysis by CE is provided in this article. With this purpose and in order to update the previous review by García-Ruiz et al., the articles appeared on this subject from January 2005 to March 2007 are considered. Three were the main strategies employed to increase the detection sensitivity in chiral analysis by CE: (i) the use of off-line sample treatment techniques, (ii) the employment of in-capillary preconcentration techniques based on electrophoretic principles, and (iii) the use of alternative detection systems to the widely employed on-column UV-Vis absorption detection. Combinations of two or three of the above-mentioned strategies gave rise to adequate concentration detection limits up to 10(-10) M enabling enantiomer analysis in a variety of real samples including complex biological matrices.

Authors+Show Affiliations

Sánchez-Hernández L
Departamento de Química Analítica, Facultad de Química, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.
Crego AL
No affiliation info available
Marina ML
No affiliation info available
García-Ruiz C
No affiliation info available

MeSH

AnimalsElectrophoresis, CapillaryHumansPharmaceutical PreparationsSensitivity and SpecificityStereoisomerism

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18161691

Citation

Sánchez-Hernández, Laura, et al. "Sensitive Chiral Analysis By CE: an Update." Electrophoresis, vol. 29, no. 1, 2008, pp. 237-51.
Sánchez-Hernández L, Crego AL, Marina ML, et al. Sensitive chiral analysis by CE: an update. Electrophoresis. 2008;29(1):237-51.
Sánchez-Hernández, L., Crego, A. L., Marina, M. L., & García-Ruiz, C. (2008). Sensitive chiral analysis by CE: an update. Electrophoresis, 29(1), 237-51.
Sánchez-Hernández L, et al. Sensitive Chiral Analysis By CE: an Update. Electrophoresis. 2008;29(1):237-51. PubMed PMID: 18161691.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sensitive chiral analysis by CE: an update. AU - Sánchez-Hernández,Laura, AU - Crego,Antonio Luis, AU - Marina,María Luisa, AU - García-Ruiz,Carmen, PY - 2007/12/29/pubmed PY - 2008/2/29/medline PY - 2007/12/29/entrez SP - 237 EP - 51 JF - Electrophoresis JO - Electrophoresis VL - 29 IS - 1 N2 - A general view of the different strategies used in the last years to enhance the detection sensitivity in chiral analysis by CE is provided in this article. With this purpose and in order to update the previous review by García-Ruiz et al., the articles appeared on this subject from January 2005 to March 2007 are considered. Three were the main strategies employed to increase the detection sensitivity in chiral analysis by CE: (i) the use of off-line sample treatment techniques, (ii) the employment of in-capillary preconcentration techniques based on electrophoretic principles, and (iii) the use of alternative detection systems to the widely employed on-column UV-Vis absorption detection. Combinations of two or three of the above-mentioned strategies gave rise to adequate concentration detection limits up to 10(-10) M enabling enantiomer analysis in a variety of real samples including complex biological matrices. SN - 0173-0835 UR - https://www.unboundmedicine.com/medline/citation/18161691/Sensitive_chiral_analysis_by_CE:_an_update_ DB - PRIME DP - Unbound Medicine ER -