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Cardiorespiratory fitness as a predictor of cancer mortality among men with pre-diabetes and diabetes.
Diabetes Care. 2008 Apr; 31(4):764-9.DC

Abstract

OBJECTIVE

The purpose of this article was to examine the risk of cancer mortality across levels of fitness and to examine the fitness-mortality relation for site-specific cancers in men with pre-diabetes and diabetes.

RESEARCH DESIGN AND METHODS

We examined the fitness-mortality relation for all-cause and site-specific cancer mortality among 18,858 men with pre-diabetes and 2,805 men with diabetes (aged 46.3 +/- 9.7 years [mean +/- SD]) from the Aerobics Center Longitudinal Study. We identified 719 cancer deaths during 354,558 person-years of risk. The duration of follow-up was 16.4 +/- 7.8 years (range <1-30.0 years).

RESULTS

In men with pre-diabetes, moderate (hazard ratio 0.71 [95% CI 0.57-0.88]) and high fitness (0.76 [0.60-0.96]) were associated with lower risks of cancer mortality compared with the low-fit group in a model adjusted for age, examination year, smoking, alcohol use, fasting glucose concentration, previous cancer, and BMI. Similarly, for individuals with diabetes, moderate (0.53 [0.35-0.82]) and high fitness (0.44 [0.26-0.73]) were associated with lower risks of cancer mortality compared with the low-fit group. Among all men, being fit was associated with a lower risk of mortality from gastrointestinal (0.55 [0.39-0.77]), colorectal (0.53 [0.30-0.96]), liver (0.22 [0.07-0.71]), and lung cancer (0.43 [0.30-0.60]).

CONCLUSIONS

In men with pre-diabetes and diabetes, higher levels of cardiorespiratory fitness were associated with lower risk of cancer mortality, particularly as a result of cancers of the gastrointestinal tract, compared with those who had low levels of fitness.

Authors+Show Affiliations

Pennington Biomedical Research Center, 4600 Perkins Rd., Baton Rouge, LA 70808-4124, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18162493

Citation

Thompson, Angela M., et al. "Cardiorespiratory Fitness as a Predictor of Cancer Mortality Among Men With Pre-diabetes and Diabetes." Diabetes Care, vol. 31, no. 4, 2008, pp. 764-9.
Thompson AM, Church TS, Janssen I, et al. Cardiorespiratory fitness as a predictor of cancer mortality among men with pre-diabetes and diabetes. Diabetes Care. 2008;31(4):764-9.
Thompson, A. M., Church, T. S., Janssen, I., Katzmarzyk, P. T., Earnest, C. P., & Blair, S. N. (2008). Cardiorespiratory fitness as a predictor of cancer mortality among men with pre-diabetes and diabetes. Diabetes Care, 31(4), 764-9.
Thompson AM, et al. Cardiorespiratory Fitness as a Predictor of Cancer Mortality Among Men With Pre-diabetes and Diabetes. Diabetes Care. 2008;31(4):764-9. PubMed PMID: 18162493.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiorespiratory fitness as a predictor of cancer mortality among men with pre-diabetes and diabetes. AU - Thompson,Angela M, AU - Church,Timothy S, AU - Janssen,Ian, AU - Katzmarzyk,Peter T, AU - Earnest,Conrad P, AU - Blair,Steven N, Y1 - 2007/12/27/ PY - 2007/12/29/pubmed PY - 2008/8/7/medline PY - 2007/12/29/entrez SP - 764 EP - 9 JF - Diabetes care JO - Diabetes Care VL - 31 IS - 4 N2 - OBJECTIVE: The purpose of this article was to examine the risk of cancer mortality across levels of fitness and to examine the fitness-mortality relation for site-specific cancers in men with pre-diabetes and diabetes. RESEARCH DESIGN AND METHODS: We examined the fitness-mortality relation for all-cause and site-specific cancer mortality among 18,858 men with pre-diabetes and 2,805 men with diabetes (aged 46.3 +/- 9.7 years [mean +/- SD]) from the Aerobics Center Longitudinal Study. We identified 719 cancer deaths during 354,558 person-years of risk. The duration of follow-up was 16.4 +/- 7.8 years (range <1-30.0 years). RESULTS: In men with pre-diabetes, moderate (hazard ratio 0.71 [95% CI 0.57-0.88]) and high fitness (0.76 [0.60-0.96]) were associated with lower risks of cancer mortality compared with the low-fit group in a model adjusted for age, examination year, smoking, alcohol use, fasting glucose concentration, previous cancer, and BMI. Similarly, for individuals with diabetes, moderate (0.53 [0.35-0.82]) and high fitness (0.44 [0.26-0.73]) were associated with lower risks of cancer mortality compared with the low-fit group. Among all men, being fit was associated with a lower risk of mortality from gastrointestinal (0.55 [0.39-0.77]), colorectal (0.53 [0.30-0.96]), liver (0.22 [0.07-0.71]), and lung cancer (0.43 [0.30-0.60]). CONCLUSIONS: In men with pre-diabetes and diabetes, higher levels of cardiorespiratory fitness were associated with lower risk of cancer mortality, particularly as a result of cancers of the gastrointestinal tract, compared with those who had low levels of fitness. SN - 1935-5548 UR - https://www.unboundmedicine.com/medline/citation/18162493/Cardiorespiratory_fitness_as_a_predictor_of_cancer_mortality_among_men_with_pre_diabetes_and_diabetes_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&amp;pmid=18162493 DB - PRIME DP - Unbound Medicine ER -