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Paraneoplastic syndromes in neuro-ophthalmology.
Curr Opin Ophthalmol 2007; 18(6):463-9CO

Abstract

PURPOSE OF REVIEW

The aim of this review is to discuss and highlight the recent advances in our understanding of paraneoplastic syndromes in neuro-ophthalmology and their significance.

RECENT FINDINGS

The pathophysiologic mechanism in neuro-ophthalmic paraneoplastic syndromes involves an immune response triggered by aberrant expression of onconeuronal antigens that cross-react with antigens in the visual system. Recently, 18-fluoro-deoxy-glucose/positron emission tomography with computed tomography scanning has emerged as a useful modality in diagnosing occult tumors responsible for paraneoplastic syndromes. Paraneoplastic optic neuropathy has been recently associated with the anti-CV2/CRMP-5 antibody. The use of serologic analysis of recombinantly expressed clones (SEREX) has led to the identification of new antigens associated with melanoma-associated retinopathy, such as visual arrestin, rhodopsin, titin, and mitofilin. Calcium-channel blockers and alemtuzumab have been found to improve visual function in cancer-associated retinopathy. Rituximab has been found to be effective in childhood opsoclonus-myoclonus syndrome.

SUMMARY

A high index of suspicion is needed to diagnose neuro-ophthalmic paraneoplastic syndromes. There have been recent advances in our understanding of the pathophysiology and treatment of these disorders. This will facilitate early treatment of causative occult tumors and improves the prognosis.

Authors+Show Affiliations

Neuro-ophthalmology Unit, Department of Ophthalmology, Ibn Sina Hospital, Kuwait City, Kuwait. dr_talal@hotmail.comNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18162997

Citation

Alabduljalil, Talal, and Raed Behbehani. "Paraneoplastic Syndromes in Neuro-ophthalmology." Current Opinion in Ophthalmology, vol. 18, no. 6, 2007, pp. 463-9.
Alabduljalil T, Behbehani R. Paraneoplastic syndromes in neuro-ophthalmology. Curr Opin Ophthalmol. 2007;18(6):463-9.
Alabduljalil, T., & Behbehani, R. (2007). Paraneoplastic syndromes in neuro-ophthalmology. Current Opinion in Ophthalmology, 18(6), pp. 463-9.
Alabduljalil T, Behbehani R. Paraneoplastic Syndromes in Neuro-ophthalmology. Curr Opin Ophthalmol. 2007;18(6):463-9. PubMed PMID: 18162997.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Paraneoplastic syndromes in neuro-ophthalmology. AU - Alabduljalil,Talal, AU - Behbehani,Raed, PY - 2007/12/29/pubmed PY - 2008/1/17/medline PY - 2007/12/29/entrez SP - 463 EP - 9 JF - Current opinion in ophthalmology JO - Curr Opin Ophthalmol VL - 18 IS - 6 N2 - PURPOSE OF REVIEW: The aim of this review is to discuss and highlight the recent advances in our understanding of paraneoplastic syndromes in neuro-ophthalmology and their significance. RECENT FINDINGS: The pathophysiologic mechanism in neuro-ophthalmic paraneoplastic syndromes involves an immune response triggered by aberrant expression of onconeuronal antigens that cross-react with antigens in the visual system. Recently, 18-fluoro-deoxy-glucose/positron emission tomography with computed tomography scanning has emerged as a useful modality in diagnosing occult tumors responsible for paraneoplastic syndromes. Paraneoplastic optic neuropathy has been recently associated with the anti-CV2/CRMP-5 antibody. The use of serologic analysis of recombinantly expressed clones (SEREX) has led to the identification of new antigens associated with melanoma-associated retinopathy, such as visual arrestin, rhodopsin, titin, and mitofilin. Calcium-channel blockers and alemtuzumab have been found to improve visual function in cancer-associated retinopathy. Rituximab has been found to be effective in childhood opsoclonus-myoclonus syndrome. SUMMARY: A high index of suspicion is needed to diagnose neuro-ophthalmic paraneoplastic syndromes. There have been recent advances in our understanding of the pathophysiology and treatment of these disorders. This will facilitate early treatment of causative occult tumors and improves the prognosis. SN - 1040-8738 UR - https://www.unboundmedicine.com/medline/citation/18162997/Paraneoplastic_syndromes_in_neuro_ophthalmology_ L2 - http://dx.doi.org/10.1097/ICU.0b013e3282f0b497 DB - PRIME DP - Unbound Medicine ER -