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Sugar-sweetened soft drinks, diet soft drinks, and serum uric acid level: the Third National Health and Nutrition Examination Survey.
Arthritis Rheum. 2008 Jan 15; 59(1):109-16.AR

Abstract

OBJECTIVE

Sugar-sweetened soft drinks contain large amounts of fructose, which may significantly increase serum uric acid levels and the risk of gout. Our objective was to evaluate the relationship between sugar-sweetened soft drink intake, diet soft drink intake, and serum uric acid levels in a nationally representative sample of men and women.

METHODS

Using data from 14,761 participants age>or=20 years from the Third National Health and Nutrition Examination Survey (1988-1994), we examined the relationship between soft drink consumption and serum uric acid levels using linear regression. Additionally, we examined the relationship between soft drink consumption and hyperuricemia (serum uric acid level>7.0 mg/dl for men and >5.7 mg/dl for women) using logistic regression. Intake was assessed by a food-frequency questionnaire.

RESULTS

Serum uric acid levels increased with increasing sugar-sweetened soft drink intake. After adjusting for covariates, serum uric acid levels associated with sugar-sweetened soft drink consumption categories (<0.5, 0.5-0.9, 1-3.9, and >or=4 servings/day) were greater than those associated with no intake by 0.08, 0.15, 0.33, and 0.42 mg/dl, respectively (95% confidence interval 0.11, 0.73; P<0.001 for trend). The multivariate odds ratios for hyperuricemia according to the corresponding sweetened soft drink consumption levels were 1.01, 1.34, 1.51, and 1.82, respectively (P=0.003 for trend). Diet soft drink consumption was not associated with serum uric acid levels or hyperuricemia (multivariate P>0.13 for trend).

CONCLUSION

These findings from a nationally representative sample of US adults suggest that sugar-sweetened soft drink consumption is associated with serum uric acid levels and frequency of hyperuricemia, but diet soft drink consumption is not.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Choi JW
Arthritis Research Centre of Canada, Vancouver, British Columbia, Canada.
Ford ES
No affiliation info available
Gao X
No affiliation info available
Choi HK
No affiliation info available

MeSH

BeveragesFemaleFructoseHumansMaleMiddle AgedNutrition SurveysUnited StatesUric Acid

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18163396

Citation

Choi, Jee Woong J., et al. "Sugar-sweetened Soft Drinks, Diet Soft Drinks, and Serum Uric Acid Level: the Third National Health and Nutrition Examination Survey." Arthritis and Rheumatism, vol. 59, no. 1, 2008, pp. 109-16.
Choi JW, Ford ES, Gao X, et al. Sugar-sweetened soft drinks, diet soft drinks, and serum uric acid level: the Third National Health and Nutrition Examination Survey. Arthritis Rheum. 2008;59(1):109-16.
Choi, J. W., Ford, E. S., Gao, X., & Choi, H. K. (2008). Sugar-sweetened soft drinks, diet soft drinks, and serum uric acid level: the Third National Health and Nutrition Examination Survey. Arthritis and Rheumatism, 59(1), 109-16. https://doi.org/10.1002/art.23245
Choi JW, et al. Sugar-sweetened Soft Drinks, Diet Soft Drinks, and Serum Uric Acid Level: the Third National Health and Nutrition Examination Survey. Arthritis Rheum. 2008 Jan 15;59(1):109-16. PubMed PMID: 18163396.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sugar-sweetened soft drinks, diet soft drinks, and serum uric acid level: the Third National Health and Nutrition Examination Survey. AU - Choi,Jee Woong J, AU - Ford,Earl S, AU - Gao,Xiang, AU - Choi,Hyon K, PY - 2008/1/1/pubmed PY - 2008/3/7/medline PY - 2008/1/1/entrez SP - 109 EP - 16 JF - Arthritis and rheumatism JO - Arthritis Rheum VL - 59 IS - 1 N2 - OBJECTIVE: Sugar-sweetened soft drinks contain large amounts of fructose, which may significantly increase serum uric acid levels and the risk of gout. Our objective was to evaluate the relationship between sugar-sweetened soft drink intake, diet soft drink intake, and serum uric acid levels in a nationally representative sample of men and women. METHODS: Using data from 14,761 participants age>or=20 years from the Third National Health and Nutrition Examination Survey (1988-1994), we examined the relationship between soft drink consumption and serum uric acid levels using linear regression. Additionally, we examined the relationship between soft drink consumption and hyperuricemia (serum uric acid level>7.0 mg/dl for men and >5.7 mg/dl for women) using logistic regression. Intake was assessed by a food-frequency questionnaire. RESULTS: Serum uric acid levels increased with increasing sugar-sweetened soft drink intake. After adjusting for covariates, serum uric acid levels associated with sugar-sweetened soft drink consumption categories (<0.5, 0.5-0.9, 1-3.9, and >or=4 servings/day) were greater than those associated with no intake by 0.08, 0.15, 0.33, and 0.42 mg/dl, respectively (95% confidence interval 0.11, 0.73; P<0.001 for trend). The multivariate odds ratios for hyperuricemia according to the corresponding sweetened soft drink consumption levels were 1.01, 1.34, 1.51, and 1.82, respectively (P=0.003 for trend). Diet soft drink consumption was not associated with serum uric acid levels or hyperuricemia (multivariate P>0.13 for trend). CONCLUSION: These findings from a nationally representative sample of US adults suggest that sugar-sweetened soft drink consumption is associated with serum uric acid levels and frequency of hyperuricemia, but diet soft drink consumption is not. SN - 0004-3591 UR - https://www.unboundmedicine.com/medline/citation/18163396/Sugar_sweetened_soft_drinks_diet_soft_drinks_and_serum_uric_acid_level:_the_Third_National_Health_and_Nutrition_Examination_Survey_ DB - PRIME DP - Unbound Medicine ER -