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Protective effect of minocycline, a semi-synthetic second-generation tetracycline against 3-nitropropionic acid (3-NP)-induced neurotoxicity.
Toxicology. 2008 Feb 28; 244(2-3):111-22.T

Abstract

3-Nitropropionic acid (3-NP) is an irreversible inhibitor of the electron transport enzyme succinate dehydrogenase, a mitochondrial Complex II enzyme. Minocycline is a semi-synthetic second-generation tetracycline with neuroprotective activity and has the capability to effectively cross the blood-brain barrier. We investigated the effects of minocycline on behavioral, biochemical, inflammation related and neurochemical alterations induced by the sub-chronic administration of 3-nitropropionic acid to rats. Chronic pre-administration of minocycline (50 and 100mg/kg) dose dependently prevented 3-NP-induced dysfunction behavioral (hypoactivity, memory retention, locomotor and rota-rod activity). In addition, 3-NP produced a marked increase in lipid peroxidation levels whereas decreased the activities of catalase and succinate dehydrogenase. In contrast, pretreatment of 3-NP injected rats with minocycline resulted in the attenuation of all these alterations. A marked increase in an inflammatory cytokine TNF-alpha by 3-NP was also decreased by minocycline treatment. Neurochemically, the administration of 3-NP significantly decreased the levels of catecholamines in the brain homogenates (dopamine, norepinephrine and serotonin) which were reversed by pretreatment of minocycline. The present finding explains the neuroprotective effect of minocycline against 3-NP toxicity by virtue of its antioxidant and anti-inflammatory activity.

Authors+Show Affiliations

Pharmacology Division, University Institute of Pharmaceutical Sciences, Punjab University, Chandigarh 160014, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18164115

Citation

Ahuja, Manuj, et al. "Protective Effect of Minocycline, a Semi-synthetic Second-generation Tetracycline Against 3-nitropropionic Acid (3-NP)-induced Neurotoxicity." Toxicology, vol. 244, no. 2-3, 2008, pp. 111-22.
Ahuja M, Bishnoi M, Chopra K. Protective effect of minocycline, a semi-synthetic second-generation tetracycline against 3-nitropropionic acid (3-NP)-induced neurotoxicity. Toxicology. 2008;244(2-3):111-22.
Ahuja, M., Bishnoi, M., & Chopra, K. (2008). Protective effect of minocycline, a semi-synthetic second-generation tetracycline against 3-nitropropionic acid (3-NP)-induced neurotoxicity. Toxicology, 244(2-3), 111-22. https://doi.org/10.1016/j.tox.2007.11.003
Ahuja M, Bishnoi M, Chopra K. Protective Effect of Minocycline, a Semi-synthetic Second-generation Tetracycline Against 3-nitropropionic Acid (3-NP)-induced Neurotoxicity. Toxicology. 2008 Feb 28;244(2-3):111-22. PubMed PMID: 18164115.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of minocycline, a semi-synthetic second-generation tetracycline against 3-nitropropionic acid (3-NP)-induced neurotoxicity. AU - Ahuja,Manuj, AU - Bishnoi,Mahendra, AU - Chopra,Kanwaljit, Y1 - 2007/11/13/ PY - 2007/05/28/received PY - 2007/11/04/revised PY - 2007/11/05/accepted PY - 2008/1/1/pubmed PY - 2008/4/10/medline PY - 2008/1/1/entrez SP - 111 EP - 22 JF - Toxicology JO - Toxicology VL - 244 IS - 2-3 N2 - 3-Nitropropionic acid (3-NP) is an irreversible inhibitor of the electron transport enzyme succinate dehydrogenase, a mitochondrial Complex II enzyme. Minocycline is a semi-synthetic second-generation tetracycline with neuroprotective activity and has the capability to effectively cross the blood-brain barrier. We investigated the effects of minocycline on behavioral, biochemical, inflammation related and neurochemical alterations induced by the sub-chronic administration of 3-nitropropionic acid to rats. Chronic pre-administration of minocycline (50 and 100mg/kg) dose dependently prevented 3-NP-induced dysfunction behavioral (hypoactivity, memory retention, locomotor and rota-rod activity). In addition, 3-NP produced a marked increase in lipid peroxidation levels whereas decreased the activities of catalase and succinate dehydrogenase. In contrast, pretreatment of 3-NP injected rats with minocycline resulted in the attenuation of all these alterations. A marked increase in an inflammatory cytokine TNF-alpha by 3-NP was also decreased by minocycline treatment. Neurochemically, the administration of 3-NP significantly decreased the levels of catecholamines in the brain homogenates (dopamine, norepinephrine and serotonin) which were reversed by pretreatment of minocycline. The present finding explains the neuroprotective effect of minocycline against 3-NP toxicity by virtue of its antioxidant and anti-inflammatory activity. SN - 0300-483X UR - https://www.unboundmedicine.com/medline/citation/18164115/Protective_effect_of_minocycline_a_semi_synthetic_second_generation_tetracycline_against_3_nitropropionic_acid__3_NP__induced_neurotoxicity_ DB - PRIME DP - Unbound Medicine ER -