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Valuation of anti-inflammatory and antinociceptive activities of Erica species native to Turkey.
J Ethnopharmacol. 2008 Mar 05; 116(2):251-7.JE

Abstract

Erica L. species (Ericaceae) have been popularly used as antirheumatic, diuretic, astringent and treatment of urinary infections. In order to evaluate this information, anti-inflammatory and antinociceptive activities of different extracts prepared with methanol, chloroform, ethyl acetate, n-butanol and water from the aerial parts of Erica arborea L., Erica manipuliflora Salisb., Erica bocquetii (Peşmen) P.F. Stevens and Erica sicula Guss. subsp. libanotica (C.&W. Barbey) P.F. Stevens (Ericaceae) of Turkish origin were investigated by using in vivo methods. For the anti-inflammatory activity, carrageenan-induced hind paw edema model, PGE(2)-induced hind paw edema model, and 12-O-tetradecanoyl-13-acetate (TPA)-induced mouse ear edema model and for the antinociceptive activity p-benzoquinone-induced writhing test in mice were employed. The ethyl acetate extracts of Erica arborea (EAE), Erica bocquetii (EBE) and Erica manipuliflora (EME) exhibited notable inhibition against carrageenan-induced (24.1-32.3%, 23.8-36.1%, 29.2-35.1%, respectively) and PGE(2)-induced (21.2-37.7%, 6.8-29.7%, and 6.2-34.1%, respectively) hind paw edema as well as TPA-induced mouse ear edema models in mice, while the ethyl acetate extract of Erica sicula subsp. libanotica (ESE) (10.7-29.7%) displayed potent anti-inflammatory activity only on the PGE(2)-induced hind paw edema model. However, the remaining extracts were found to be inactive against inflammatory models. Same extracts, i.e., EAE, EBE and EME were also found to exhibit remarkable antinociceptive activity in p-benzoquinone-induced abdominal constriction test at a dose of 100mg/kg (46.5%, 27.7% and 36.3%, respectively).

Authors+Show Affiliations

Gazi University, Faculty of Pharmacy, Department of Pharmacognosy, Etiler 06330, Ankara, Turkey. esrak@gazi.edu.trNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18164152

Citation

Akkol, Esra Küpeli, et al. "Valuation of Anti-inflammatory and Antinociceptive Activities of Erica Species Native to Turkey." Journal of Ethnopharmacology, vol. 116, no. 2, 2008, pp. 251-7.
Akkol EK, Yeşilada E, Güvenç A. Valuation of anti-inflammatory and antinociceptive activities of Erica species native to Turkey. J Ethnopharmacol. 2008;116(2):251-7.
Akkol, E. K., Yeşilada, E., & Güvenç, A. (2008). Valuation of anti-inflammatory and antinociceptive activities of Erica species native to Turkey. Journal of Ethnopharmacology, 116(2), 251-7. https://doi.org/10.1016/j.jep.2007.11.023
Akkol EK, Yeşilada E, Güvenç A. Valuation of Anti-inflammatory and Antinociceptive Activities of Erica Species Native to Turkey. J Ethnopharmacol. 2008 Mar 5;116(2):251-7. PubMed PMID: 18164152.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Valuation of anti-inflammatory and antinociceptive activities of Erica species native to Turkey. AU - Akkol,Esra Küpeli, AU - Yeşilada,Erdem, AU - Güvenç,Aysegül, Y1 - 2007/11/22/ PY - 2007/07/24/received PY - 2007/10/30/revised PY - 2007/11/15/accepted PY - 2008/1/1/pubmed PY - 2008/8/1/medline PY - 2008/1/1/entrez SP - 251 EP - 7 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 116 IS - 2 N2 - Erica L. species (Ericaceae) have been popularly used as antirheumatic, diuretic, astringent and treatment of urinary infections. In order to evaluate this information, anti-inflammatory and antinociceptive activities of different extracts prepared with methanol, chloroform, ethyl acetate, n-butanol and water from the aerial parts of Erica arborea L., Erica manipuliflora Salisb., Erica bocquetii (Peşmen) P.F. Stevens and Erica sicula Guss. subsp. libanotica (C.&W. Barbey) P.F. Stevens (Ericaceae) of Turkish origin were investigated by using in vivo methods. For the anti-inflammatory activity, carrageenan-induced hind paw edema model, PGE(2)-induced hind paw edema model, and 12-O-tetradecanoyl-13-acetate (TPA)-induced mouse ear edema model and for the antinociceptive activity p-benzoquinone-induced writhing test in mice were employed. The ethyl acetate extracts of Erica arborea (EAE), Erica bocquetii (EBE) and Erica manipuliflora (EME) exhibited notable inhibition against carrageenan-induced (24.1-32.3%, 23.8-36.1%, 29.2-35.1%, respectively) and PGE(2)-induced (21.2-37.7%, 6.8-29.7%, and 6.2-34.1%, respectively) hind paw edema as well as TPA-induced mouse ear edema models in mice, while the ethyl acetate extract of Erica sicula subsp. libanotica (ESE) (10.7-29.7%) displayed potent anti-inflammatory activity only on the PGE(2)-induced hind paw edema model. However, the remaining extracts were found to be inactive against inflammatory models. Same extracts, i.e., EAE, EBE and EME were also found to exhibit remarkable antinociceptive activity in p-benzoquinone-induced abdominal constriction test at a dose of 100mg/kg (46.5%, 27.7% and 36.3%, respectively). SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/18164152/Valuation_of_anti_inflammatory_and_antinociceptive_activities_of_Erica_species_native_to_Turkey_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(07)00618-6 DB - PRIME DP - Unbound Medicine ER -