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Circulating leptin and ghrelin are differentially influenced by estrogen/progestin therapy and raloxifene.
Maturitas. 2008 Jan 20; 59(1):62-71.M

Abstract

BACKGROUND

Leptin and ghrelin are increasingly being recognized as cardiotropic hormones, promoting or inhibiting the atherosclerotic process, respectively. Apoptosis may be one pathway through which the actions of these hormones are mediated. Sex hormones are reported to influence the secretion and action of ghrelin and leptin.

OBJECTIVE

To evaluate (1) the association of circulating ghrelin and leptin with selected markers of receptor-mediated apoptosis and (2) the effect of estrogen monotherapy, low dose estrogen-progestin therapy, tibolone and raloxifene on serum ghrelin and leptin in healthy postmenopausal women.

METHODS

Eighty eight postmenopausal women aged 44-62 years were randomly allocated to daily (1) conjugated equine estrogens 0.625 mg (CEE), (2) 17beta-estradiol 1mg plus norethisterone acetate 0.5 mg (E(2)/NETA), (3) tibolone 2.5mg, (4) raloxifene HCl 60 mg or (5) no treatment. Serum markers of apoptosis sFas, Fas-ligand (Fas-L) and caspase-1 were measured at baseline. Serum leptin and ghrelin were measured at baseline and at 3 months.

RESULTS

Body Mass Index (BMI) and estradiol levels correlated positively, while FSH correlated negatively with serum leptin (BMI: r=0.646, p=0.005, estradiol: r=0.432, p=0.001, FSH: r=-0.401, p=0.002). Insulin levels associated positively with circulating leptin (r=0.394, p=0.011) and negatively with circulating ghrelin (r=-0.401, p=0.009). Serum leptin decreased significantly in E2/NETA group (baseline: 2.882+/-0.76 ng/ml, 3 months: 2.687+/-0.66 ng/ml, p=0.043), while it increased significantly in the raloxifene group (baseline: 2.671+/-0.54 ng/ml, 3 months: 2.839+/-0.47 ng/ml). Ghrelin levels decreased significantly only in the raloxifene group (baseline: 1634+/-592 pg/ml, 3 months: 1408+/-534 pg/ml).

CONCLUSION

Apoptosis may be a pathway through which leptin exerts a pro-atherogenic effect. Low dose HT may act cardioprotectively by decreasing leptin levels in healthy recently menopaused women.

Authors+Show Affiliations

2nd Department of Obstetrics and Gynecology, University of Athens, Aretaieio Hospital, 27 Themistokleous Street, Dionysos, Athens, Greece. ilambrinoudaki@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

18164562

Citation

Lambrinoudaki, Irene V., et al. "Circulating Leptin and Ghrelin Are Differentially Influenced By Estrogen/progestin Therapy and Raloxifene." Maturitas, vol. 59, no. 1, 2008, pp. 62-71.
Lambrinoudaki IV, Christodoulakos GE, Economou EV, et al. Circulating leptin and ghrelin are differentially influenced by estrogen/progestin therapy and raloxifene. Maturitas. 2008;59(1):62-71.
Lambrinoudaki, I. V., Christodoulakos, G. E., Economou, E. V., Vlachou, S. A., Panoulis, C. P., Alexandrou, A. P., Kouskouni, E. E., & Creatsas, G. C. (2008). Circulating leptin and ghrelin are differentially influenced by estrogen/progestin therapy and raloxifene. Maturitas, 59(1), 62-71. https://doi.org/10.1016/j.maturitas.2007.10.003
Lambrinoudaki IV, et al. Circulating Leptin and Ghrelin Are Differentially Influenced By Estrogen/progestin Therapy and Raloxifene. Maturitas. 2008 Jan 20;59(1):62-71. PubMed PMID: 18164562.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circulating leptin and ghrelin are differentially influenced by estrogen/progestin therapy and raloxifene. AU - Lambrinoudaki,Irene V, AU - Christodoulakos,George E, AU - Economou,Emmanuel V, AU - Vlachou,Sofia A, AU - Panoulis,Constantinos P, AU - Alexandrou,Andreas P, AU - Kouskouni,Evangelia E, AU - Creatsas,George C, PY - 2007/06/28/received PY - 2007/10/08/revised PY - 2007/10/16/accepted PY - 2008/1/1/pubmed PY - 2008/5/9/medline PY - 2008/1/1/entrez SP - 62 EP - 71 JF - Maturitas JO - Maturitas VL - 59 IS - 1 N2 - BACKGROUND: Leptin and ghrelin are increasingly being recognized as cardiotropic hormones, promoting or inhibiting the atherosclerotic process, respectively. Apoptosis may be one pathway through which the actions of these hormones are mediated. Sex hormones are reported to influence the secretion and action of ghrelin and leptin. OBJECTIVE: To evaluate (1) the association of circulating ghrelin and leptin with selected markers of receptor-mediated apoptosis and (2) the effect of estrogen monotherapy, low dose estrogen-progestin therapy, tibolone and raloxifene on serum ghrelin and leptin in healthy postmenopausal women. METHODS: Eighty eight postmenopausal women aged 44-62 years were randomly allocated to daily (1) conjugated equine estrogens 0.625 mg (CEE), (2) 17beta-estradiol 1mg plus norethisterone acetate 0.5 mg (E(2)/NETA), (3) tibolone 2.5mg, (4) raloxifene HCl 60 mg or (5) no treatment. Serum markers of apoptosis sFas, Fas-ligand (Fas-L) and caspase-1 were measured at baseline. Serum leptin and ghrelin were measured at baseline and at 3 months. RESULTS: Body Mass Index (BMI) and estradiol levels correlated positively, while FSH correlated negatively with serum leptin (BMI: r=0.646, p=0.005, estradiol: r=0.432, p=0.001, FSH: r=-0.401, p=0.002). Insulin levels associated positively with circulating leptin (r=0.394, p=0.011) and negatively with circulating ghrelin (r=-0.401, p=0.009). Serum leptin decreased significantly in E2/NETA group (baseline: 2.882+/-0.76 ng/ml, 3 months: 2.687+/-0.66 ng/ml, p=0.043), while it increased significantly in the raloxifene group (baseline: 2.671+/-0.54 ng/ml, 3 months: 2.839+/-0.47 ng/ml). Ghrelin levels decreased significantly only in the raloxifene group (baseline: 1634+/-592 pg/ml, 3 months: 1408+/-534 pg/ml). CONCLUSION: Apoptosis may be a pathway through which leptin exerts a pro-atherogenic effect. Low dose HT may act cardioprotectively by decreasing leptin levels in healthy recently menopaused women. SN - 0378-5122 UR - https://www.unboundmedicine.com/medline/citation/18164562/Circulating_leptin_and_ghrelin_are_differentially_influenced_by_estrogen/progestin_therapy_and_raloxifene_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5122(07)00295-2 DB - PRIME DP - Unbound Medicine ER -