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Anti-inflammatory and anti-nociceptive activities of Fumaria indica whole plant extract in experimental animals.
Acta Pharm. 2007 Dec; 57(4):491-8.AP

Abstract

The 50% ethanolic extract of Fumaria indica was investigated for its anti-inflammatory and antinociceptive potential in animal models. Oral administration of F. indica dry extract (100, 200 and 400 mg kg-1) exhibited dose dependent and significant anti-inflammatory activity in acute (carrageenean and histamine induced hind paw oedema, p < 0.05) and chronic cotton pellet granuloma models of inflammation, p < 0.01). The extract (400 mg kg-1) exhibited maximum anti-inflammatory effects of 42.2 and 42.1% after 3 h with carrageenean and histamine, respectively. The same dose of extract showed 38.9% reduction in granuloma mass in a chronic condition. A significant anti-nociceptive activity was evidenced in mice; 6.6-67.7% (p < 0.01) protection in mechanical, 33.9-125.1% (p < 0.05) protection in thermal induced pain and 22.2-73.9% (p < 0.05) protection in acetic acid-induced writhing.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Rao CV
Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute, Rana Pratap Marg, Lucknow-226001, India. chvrao72@yahoo.com
Verma AR
No affiliation info available
Gupta PK
No affiliation info available
Vijayakumar M
No affiliation info available

MeSH

Acetic AcidAdministration, OralAnalgesicsAnimalsAnti-Inflammatory AgentsCarrageenanCotton FiberDisease Models, AnimalDose-Response Relationship, DrugEdemaFumariaGranuloma, Foreign-BodyHistamineHot TemperatureInflammationMaleMicePainPain MeasurementPain ThresholdPlant ExtractsRatsRats, Sprague-DawleyTouch

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18165192

Citation

Rao, Chandana Venkateswara, et al. "Anti-inflammatory and Anti-nociceptive Activities of Fumaria Indica Whole Plant Extract in Experimental Animals." Acta Pharmaceutica (Zagreb, Croatia), vol. 57, no. 4, 2007, pp. 491-8.
Rao CV, Verma AR, Gupta PK, et al. Anti-inflammatory and anti-nociceptive activities of Fumaria indica whole plant extract in experimental animals. Acta Pharm. 2007;57(4):491-8.
Rao, C. V., Verma, A. R., Gupta, P. K., & Vijayakumar, M. (2007). Anti-inflammatory and anti-nociceptive activities of Fumaria indica whole plant extract in experimental animals. Acta Pharmaceutica (Zagreb, Croatia), 57(4), 491-8. https://doi.org/10.2478/v10007-007-0039-z
Rao CV, et al. Anti-inflammatory and Anti-nociceptive Activities of Fumaria Indica Whole Plant Extract in Experimental Animals. Acta Pharm. 2007;57(4):491-8. PubMed PMID: 18165192.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory and anti-nociceptive activities of Fumaria indica whole plant extract in experimental animals. AU - Rao,Chandana Venkateswara, AU - Verma,Arti Raj, AU - Gupta,Praksh Kumar, AU - Vijayakumar,Madhavan, PY - 2008/1/1/pubmed PY - 2008/4/11/medline PY - 2008/1/1/entrez SP - 491 EP - 8 JF - Acta pharmaceutica (Zagreb, Croatia) JO - Acta Pharm VL - 57 IS - 4 N2 - The 50% ethanolic extract of Fumaria indica was investigated for its anti-inflammatory and antinociceptive potential in animal models. Oral administration of F. indica dry extract (100, 200 and 400 mg kg-1) exhibited dose dependent and significant anti-inflammatory activity in acute (carrageenean and histamine induced hind paw oedema, p < 0.05) and chronic cotton pellet granuloma models of inflammation, p < 0.01). The extract (400 mg kg-1) exhibited maximum anti-inflammatory effects of 42.2 and 42.1% after 3 h with carrageenean and histamine, respectively. The same dose of extract showed 38.9% reduction in granuloma mass in a chronic condition. A significant anti-nociceptive activity was evidenced in mice; 6.6-67.7% (p < 0.01) protection in mechanical, 33.9-125.1% (p < 0.05) protection in thermal induced pain and 22.2-73.9% (p < 0.05) protection in acetic acid-induced writhing. SN - 1330-0075 UR - https://www.unboundmedicine.com/medline/citation/18165192/Anti_inflammatory_and_anti_nociceptive_activities_of_Fumaria_indica_whole_plant_extract_in_experimental_animals_ DB - PRIME DP - Unbound Medicine ER -