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Synthesis and performance of novel hydrogels coatings for implantable glucose sensors.
Biomacromolecules. 2008 Feb; 9(2):561-7.B

Abstract

Novel hydrogel polymers were prepared, characterized, coated on implantable glucose sensors, and tested in vitro and in vivo. The effects of 2,3-dihydroxypropyl methacrylate (DHPMA) on the swelling, morphology, glass transition (T(g)), and water structure were studied. The results show that the degree of swelling increases with increasing DHPMA content. Scanning electron microscopy (SEM) studies identified uniform, porous structures in samples containing 60-90 mol % DHPMA. Glass-transition temperatures did not change significantly with DHPMA content, but the ratio of freezing to nonfreezing water tended to increase with DHPMA content. Sensors coated with different hydrogels were prepared and in vitro evaluations were performed. The 80% DHPMA hydrogels exhibited optimum sensitivity, response, and stability when coated directly onto the sensor or top of a polyurethane (PU) layer. The histology results show that 80% DHPMA samples exhibit reduced fibrosis and reduced inflammation, resulting in a longer functional life.

Authors+Show Affiliations

Department of Chemistry, University of South Florida, 4202 East Fowler Avenue, CHE 205, Tampa, Florida 33620-5250, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18166014

Citation

Wang, Chunyan, et al. "Synthesis and Performance of Novel Hydrogels Coatings for Implantable Glucose Sensors." Biomacromolecules, vol. 9, no. 2, 2008, pp. 561-7.
Wang C, Yu B, Knudsen B, et al. Synthesis and performance of novel hydrogels coatings for implantable glucose sensors. Biomacromolecules. 2008;9(2):561-7.
Wang, C., Yu, B., Knudsen, B., Harmon, J., Moussy, F., & Moussy, Y. (2008). Synthesis and performance of novel hydrogels coatings for implantable glucose sensors. Biomacromolecules, 9(2), 561-7. https://doi.org/10.1021/bm701102y
Wang C, et al. Synthesis and Performance of Novel Hydrogels Coatings for Implantable Glucose Sensors. Biomacromolecules. 2008;9(2):561-7. PubMed PMID: 18166014.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis and performance of novel hydrogels coatings for implantable glucose sensors. AU - Wang,Chunyan, AU - Yu,Bazhang, AU - Knudsen,Bernard, AU - Harmon,Julie, AU - Moussy,Francis, AU - Moussy,Yvvone, Y1 - 2008/01/01/ PY - 2008/1/2/pubmed PY - 2008/4/15/medline PY - 2008/1/2/entrez SP - 561 EP - 7 JF - Biomacromolecules JO - Biomacromolecules VL - 9 IS - 2 N2 - Novel hydrogel polymers were prepared, characterized, coated on implantable glucose sensors, and tested in vitro and in vivo. The effects of 2,3-dihydroxypropyl methacrylate (DHPMA) on the swelling, morphology, glass transition (T(g)), and water structure were studied. The results show that the degree of swelling increases with increasing DHPMA content. Scanning electron microscopy (SEM) studies identified uniform, porous structures in samples containing 60-90 mol % DHPMA. Glass-transition temperatures did not change significantly with DHPMA content, but the ratio of freezing to nonfreezing water tended to increase with DHPMA content. Sensors coated with different hydrogels were prepared and in vitro evaluations were performed. The 80% DHPMA hydrogels exhibited optimum sensitivity, response, and stability when coated directly onto the sensor or top of a polyurethane (PU) layer. The histology results show that 80% DHPMA samples exhibit reduced fibrosis and reduced inflammation, resulting in a longer functional life. SN - 1526-4602 UR - https://www.unboundmedicine.com/medline/citation/18166014/Synthesis_and_performance_of_novel_hydrogels_coatings_for_implantable_glucose_sensors_ L2 - https://doi.org/10.1021/bm701102y DB - PRIME DP - Unbound Medicine ER -