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Advances and remaining uncertainties in the epidemiology of Burkholderia pseudomallei and melioidosis.
Trans R Soc Trop Med Hyg. 2008 Mar; 102(3):225-7.TR

Abstract

Major advances have been made in molecular studies of Burkholderia pseudomallei and the immunology of melioidosis. However, there remain large gaps in understanding of the epidemiology of this enigmatic disease. Identified global distribution boundaries of melioidosis continue to expand. Recent data suggest Australian strains of B. pseudomallei may be ancestral to those from Southeast Asia, but the ecology of this environmental bacterium remains elusive. Despite the potential for rapidly progressive septicaemia, the critical virulence factors in B. pseudomallei remain to be clarified. Inhalation following aerosolization of B. pseudomallei may account for the high mortality when melioidosis occurs after severe weather events.

Authors+Show Affiliations

Menzies School of Health Research, Charles Darwin University, and Northern Territory Clinical School, Flinders University, Darwin, Northern Territory Australia. bart@menzies.edu.au

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18166205

Citation

Currie, Bart J.. "Advances and Remaining Uncertainties in the Epidemiology of Burkholderia Pseudomallei and Melioidosis." Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 102, no. 3, 2008, pp. 225-7.
Currie BJ. Advances and remaining uncertainties in the epidemiology of Burkholderia pseudomallei and melioidosis. Trans R Soc Trop Med Hyg. 2008;102(3):225-7.
Currie, B. J. (2008). Advances and remaining uncertainties in the epidemiology of Burkholderia pseudomallei and melioidosis. Transactions of the Royal Society of Tropical Medicine and Hygiene, 102(3), 225-7. https://doi.org/10.1016/j.trstmh.2007.11.005
Currie BJ. Advances and Remaining Uncertainties in the Epidemiology of Burkholderia Pseudomallei and Melioidosis. Trans R Soc Trop Med Hyg. 2008;102(3):225-7. PubMed PMID: 18166205.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Advances and remaining uncertainties in the epidemiology of Burkholderia pseudomallei and melioidosis. A1 - Currie,Bart J, Y1 - 2007/12/31/ PY - 2007/08/13/received PY - 2007/11/06/revised PY - 2007/11/07/accepted PY - 2008/1/2/pubmed PY - 2008/10/28/medline PY - 2008/1/2/entrez SP - 225 EP - 7 JF - Transactions of the Royal Society of Tropical Medicine and Hygiene JO - Trans. R. Soc. Trop. Med. Hyg. VL - 102 IS - 3 N2 - Major advances have been made in molecular studies of Burkholderia pseudomallei and the immunology of melioidosis. However, there remain large gaps in understanding of the epidemiology of this enigmatic disease. Identified global distribution boundaries of melioidosis continue to expand. Recent data suggest Australian strains of B. pseudomallei may be ancestral to those from Southeast Asia, but the ecology of this environmental bacterium remains elusive. Despite the potential for rapidly progressive septicaemia, the critical virulence factors in B. pseudomallei remain to be clarified. Inhalation following aerosolization of B. pseudomallei may account for the high mortality when melioidosis occurs after severe weather events. SN - 0035-9203 UR - https://www.unboundmedicine.com/medline/citation/18166205/Advances_and_remaining_uncertainties_in_the_epidemiology_of_Burkholderia_pseudomallei_and_melioidosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0035-9203(07)00395-1 DB - PRIME DP - Unbound Medicine ER -
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