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Comparison of the 24-hour intraocular pressure-lowering effects of latanoprost and dorzolamide/timolol fixed combination after 2 and 6 months of treatment.
Ophthalmology. 2008 Jan; 115(1):99-103.O

Abstract

PURPOSE

To evaluate the 24-hour intraocular pressure (IOP)-lowering effect of latanoprost and the dorzolamide/timolol fixed combination (DTFC) after 2 and 6 months of treatment.

DESIGN

Randomized, prospective, crossover comparison.

PARTICIPANTS

Thirty-nine patients had primary open-angle glaucoma, and 14 patients had ocular hypertension.

METHODS

After a 6-week washout period, patients were randomized to either 6 months of treatment with the DTFC twice daily or latanoprost every evening and then crossed over to the opposite treatment for an additional 6 months.

MAIN OUTCOME MEASURE

Mean 24-hour IOP after 2 and 6 months of treatment.

RESULTS

Fifty-three patients had an average 24-hour baseline IOP of 25.2+/-2.3 mmHg. After 6 months of treatment, 24-hour IOPs were 18.1+/-1.9 mmHg for the DTFC and 18.3+/-1.9 mmHg for latanoprost. Compared with 2 months of therapy, at 6 months the DTFC showed no significant change in mean 24-hour IOP, whereas latanoprost demonstrated a reduction of 0.3 mmHg (P = 0.01). The DTFC had more burning (P<0.001) and bitter taste (P = 0.01), whereas the latanoprost had more hypertrichosis (P = 0.02).

CONCLUSIONS

After 6 months of therapy, the DTFC and latanoprost have clinically similar 24-hour IOP-lowering efficacies.

Authors+Show Affiliations

Glaucoma Unit, First University Department of Ophthalmology, AHEPA Hospital, Thessaloniki, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18166407

Citation

Konstas, Anastasios G P., et al. "Comparison of the 24-hour Intraocular Pressure-lowering Effects of Latanoprost and Dorzolamide/timolol Fixed Combination After 2 and 6 Months of Treatment." Ophthalmology, vol. 115, no. 1, 2008, pp. 99-103.
Konstas AG, Kozobolis VP, Tsironi S, et al. Comparison of the 24-hour intraocular pressure-lowering effects of latanoprost and dorzolamide/timolol fixed combination after 2 and 6 months of treatment. Ophthalmology. 2008;115(1):99-103.
Konstas, A. G., Kozobolis, V. P., Tsironi, S., Makridaki, I., Efremova, R., & Stewart, W. C. (2008). Comparison of the 24-hour intraocular pressure-lowering effects of latanoprost and dorzolamide/timolol fixed combination after 2 and 6 months of treatment. Ophthalmology, 115(1), 99-103. https://doi.org/10.1016/j.ophtha.2007.03.007
Konstas AG, et al. Comparison of the 24-hour Intraocular Pressure-lowering Effects of Latanoprost and Dorzolamide/timolol Fixed Combination After 2 and 6 Months of Treatment. Ophthalmology. 2008;115(1):99-103. PubMed PMID: 18166407.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of the 24-hour intraocular pressure-lowering effects of latanoprost and dorzolamide/timolol fixed combination after 2 and 6 months of treatment. AU - Konstas,Anastasios G P, AU - Kozobolis,Vassilios P, AU - Tsironi,Sevasti, AU - Makridaki,Irene, AU - Efremova,Rallitsa, AU - Stewart,William C, PY - 2006/08/25/received PY - 2007/02/28/revised PY - 2007/03/01/accepted PY - 2008/1/2/pubmed PY - 2008/1/15/medline PY - 2008/1/2/entrez SP - 99 EP - 103 JF - Ophthalmology JO - Ophthalmology VL - 115 IS - 1 N2 - PURPOSE: To evaluate the 24-hour intraocular pressure (IOP)-lowering effect of latanoprost and the dorzolamide/timolol fixed combination (DTFC) after 2 and 6 months of treatment. DESIGN: Randomized, prospective, crossover comparison. PARTICIPANTS: Thirty-nine patients had primary open-angle glaucoma, and 14 patients had ocular hypertension. METHODS: After a 6-week washout period, patients were randomized to either 6 months of treatment with the DTFC twice daily or latanoprost every evening and then crossed over to the opposite treatment for an additional 6 months. MAIN OUTCOME MEASURE: Mean 24-hour IOP after 2 and 6 months of treatment. RESULTS: Fifty-three patients had an average 24-hour baseline IOP of 25.2+/-2.3 mmHg. After 6 months of treatment, 24-hour IOPs were 18.1+/-1.9 mmHg for the DTFC and 18.3+/-1.9 mmHg for latanoprost. Compared with 2 months of therapy, at 6 months the DTFC showed no significant change in mean 24-hour IOP, whereas latanoprost demonstrated a reduction of 0.3 mmHg (P = 0.01). The DTFC had more burning (P<0.001) and bitter taste (P = 0.01), whereas the latanoprost had more hypertrichosis (P = 0.02). CONCLUSIONS: After 6 months of therapy, the DTFC and latanoprost have clinically similar 24-hour IOP-lowering efficacies. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/18166407/Comparison_of_the_24_hour_intraocular_pressure_lowering_effects_of_latanoprost_and_dorzolamide/timolol_fixed_combination_after_2_and_6_months_of_treatment_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(07)00232-1 DB - PRIME DP - Unbound Medicine ER -