Tags

Type your tag names separated by a space and hit enter

Timing of solid food introduction in relation to eczema, asthma, allergic rhinitis, and food and inhalant sensitization at the age of 6 years: results from the prospective birth cohort study LISA.

Abstract

OBJECTIVE

Current prophylactic feeding guidelines recommend a delayed introduction of solids for the prevention of atopic diseases. This study investigates whether a delayed introduction of solids (past 4 or 6 months) is protective against the development of eczema, asthma, allergic rhinitis, and food or inhalant sensitization at the age of 6 years.

METHODS

Data from 2073 children in the ongoing LISA birth cohort study were analyzed at 6 years of age. Multivariate logistic regression analyses were performed for all children and for children without skin or allergic symptoms within the first 6 months of life to take into account reverse causality.

RESULTS

A delayed introduction of solids (past 4 or 6 months) was not associated with decreased odds for asthma, allergic rhinitis, or sensitization against food or inhalant allergens at 6 years of age. On the contrary, food sensitization was more frequent in children who were introduced to solids later. The relationship between the timing of solid food introduction and eczema was not clear. There was no protective effect of a late introduction of solids or a less diverse diet within the first 4 months of life. However, in children without early skin or allergic symptoms were considered, eczema was significantly more frequent in children who received a more diverse diet within the first 4 months.

CONCLUSIONS

This study found no evidence supporting a delayed introduction of solids beyond 4 or 6 months for the prevention of asthma, allergic rhinitis, and food or inhalant sensitization at the age of 6 years. For eczema, the results were conflicting, and a protective effect of a delayed introduction of solids cannot be excluded. Positive associations between late introduction of solids and food sensitization have to be interpreted with caution. A true protective effect of a delayed introduction of solids on food sensitization seems unlikely.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    GSF-National Research Center for Environment and Health, Institute of Epidemiology, 85764 Neuherberg, Germany.

    , , , , , , , , , ,

    Source

    Pediatrics 121:1 2008 Jan pg e44-52

    MeSH

    Age Distribution
    Asthma
    Child
    Child, Preschool
    Cohort Studies
    Confidence Intervals
    Eczema
    Female
    Follow-Up Studies
    Food Hypersensitivity
    Humans
    Incidence
    Infant
    Infant Food
    Male
    Multivariate Analysis
    Odds Ratio
    Prospective Studies
    Registries
    Regression Analysis
    Rhinitis, Allergic, Perennial
    Risk Factors
    Sex Distribution
    Surveys and Questionnaires
    Time Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    18166543

    Citation

    Zutavern, Anne, et al. "Timing of Solid Food Introduction in Relation to Eczema, Asthma, Allergic Rhinitis, and Food and Inhalant Sensitization at the Age of 6 Years: Results From the Prospective Birth Cohort Study LISA." Pediatrics, vol. 121, no. 1, 2008, pp. e44-52.
    Zutavern A, Brockow I, Schaaf B, et al. Timing of solid food introduction in relation to eczema, asthma, allergic rhinitis, and food and inhalant sensitization at the age of 6 years: results from the prospective birth cohort study LISA. Pediatrics. 2008;121(1):e44-52.
    Zutavern, A., Brockow, I., Schaaf, B., von Berg, A., Diez, U., Borte, M., ... Heinrich, J. (2008). Timing of solid food introduction in relation to eczema, asthma, allergic rhinitis, and food and inhalant sensitization at the age of 6 years: results from the prospective birth cohort study LISA. Pediatrics, 121(1), pp. e44-52. doi:10.1542/peds.2006-3553.
    Zutavern A, et al. Timing of Solid Food Introduction in Relation to Eczema, Asthma, Allergic Rhinitis, and Food and Inhalant Sensitization at the Age of 6 Years: Results From the Prospective Birth Cohort Study LISA. Pediatrics. 2008;121(1):e44-52. PubMed PMID: 18166543.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Timing of solid food introduction in relation to eczema, asthma, allergic rhinitis, and food and inhalant sensitization at the age of 6 years: results from the prospective birth cohort study LISA. AU - Zutavern,Anne, AU - Brockow,Inken, AU - Schaaf,Beate, AU - von Berg,Andrea, AU - Diez,Ulrike, AU - Borte,Michael, AU - Kraemer,Ursula, AU - Herbarth,Olf, AU - Behrendt,Heidrun, AU - Wichmann,H-Erich, AU - Heinrich,Joachim, AU - ,, PY - 2008/1/2/pubmed PY - 2008/2/6/medline PY - 2008/1/2/entrez SP - e44 EP - 52 JF - Pediatrics JO - Pediatrics VL - 121 IS - 1 N2 - OBJECTIVE: Current prophylactic feeding guidelines recommend a delayed introduction of solids for the prevention of atopic diseases. This study investigates whether a delayed introduction of solids (past 4 or 6 months) is protective against the development of eczema, asthma, allergic rhinitis, and food or inhalant sensitization at the age of 6 years. METHODS: Data from 2073 children in the ongoing LISA birth cohort study were analyzed at 6 years of age. Multivariate logistic regression analyses were performed for all children and for children without skin or allergic symptoms within the first 6 months of life to take into account reverse causality. RESULTS: A delayed introduction of solids (past 4 or 6 months) was not associated with decreased odds for asthma, allergic rhinitis, or sensitization against food or inhalant allergens at 6 years of age. On the contrary, food sensitization was more frequent in children who were introduced to solids later. The relationship between the timing of solid food introduction and eczema was not clear. There was no protective effect of a late introduction of solids or a less diverse diet within the first 4 months of life. However, in children without early skin or allergic symptoms were considered, eczema was significantly more frequent in children who received a more diverse diet within the first 4 months. CONCLUSIONS: This study found no evidence supporting a delayed introduction of solids beyond 4 or 6 months for the prevention of asthma, allergic rhinitis, and food or inhalant sensitization at the age of 6 years. For eczema, the results were conflicting, and a protective effect of a delayed introduction of solids cannot be excluded. Positive associations between late introduction of solids and food sensitization have to be interpreted with caution. A true protective effect of a delayed introduction of solids on food sensitization seems unlikely. SN - 1098-4275 UR - https://www.unboundmedicine.com/medline/citation/18166543/Timing_of_solid_food_introduction_in_relation_to_eczema_asthma_allergic_rhinitis_and_food_and_inhalant_sensitization_at_the_age_of_6_years:_results_from_the_prospective_birth_cohort_study_LISA_ L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&pmid=18166543 DB - PRIME DP - Unbound Medicine ER -