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Fruit and vegetable intake and gastric cancer risk in a large United States prospective cohort study.
Cancer Causes Control 2008; 19(5):459-67CC

Abstract

OBJECTIVE

Fruit and vegetable intake may protect against gastric cancer incidence. Results from case-control studies have indicated an inverse association, but results from cohort studies are inconsistent.

METHODS

We prospectively investigated the association in 490,802 participants of the NIH-AARP Diet and Health Study using Cox proportional hazards models adjusted for gastric cancer risk factors. We present hazard ratios (HR) and 95% confidence intervals (CI) per increase of one daily serving per 1,000 calories.

RESULTS

During 2,193,751 person years, 394 participants were diagnosed with incident gastric cancer. We observed no significant associations between total fruit and vegetable intake (1.01, 0.95-1.08), fruit intake (1.04, 0.95-1.14), or vegetable intake (0.98, 0.88-1.08) and gastric cancer risk. Results did not vary by sex or anatomic subsite (cardia versus non-cardia). All 13 botanical subgroups examined had no significant associations with either anatomic sub-site.

CONCLUSION

We did not observe significant associations between overall fruit and vegetable intake and gastric cancer risk in this large prospective cohort study.

Authors+Show Affiliations

Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. freedmanne@mail.nih.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

18166992

Citation

Freedman, Neal D., et al. "Fruit and Vegetable Intake and Gastric Cancer Risk in a Large United States Prospective Cohort Study." Cancer Causes & Control : CCC, vol. 19, no. 5, 2008, pp. 459-67.
Freedman ND, Subar AF, Hollenbeck AR, et al. Fruit and vegetable intake and gastric cancer risk in a large United States prospective cohort study. Cancer Causes Control. 2008;19(5):459-67.
Freedman, N. D., Subar, A. F., Hollenbeck, A. R., Leitzmann, M. F., Schatzkin, A., & Abnet, C. C. (2008). Fruit and vegetable intake and gastric cancer risk in a large United States prospective cohort study. Cancer Causes & Control : CCC, 19(5), pp. 459-67. doi:10.1007/s10552-007-9107-4.
Freedman ND, et al. Fruit and Vegetable Intake and Gastric Cancer Risk in a Large United States Prospective Cohort Study. Cancer Causes Control. 2008;19(5):459-67. PubMed PMID: 18166992.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fruit and vegetable intake and gastric cancer risk in a large United States prospective cohort study. AU - Freedman,Neal D, AU - Subar,Amy F, AU - Hollenbeck,Albert R, AU - Leitzmann,Michael F, AU - Schatzkin,Arthur, AU - Abnet,Christian C, Y1 - 2008/01/01/ PY - 2007/07/25/received PY - 2007/12/18/accepted PY - 2008/1/2/pubmed PY - 2008/10/1/medline PY - 2008/1/2/entrez SP - 459 EP - 67 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 19 IS - 5 N2 - OBJECTIVE: Fruit and vegetable intake may protect against gastric cancer incidence. Results from case-control studies have indicated an inverse association, but results from cohort studies are inconsistent. METHODS: We prospectively investigated the association in 490,802 participants of the NIH-AARP Diet and Health Study using Cox proportional hazards models adjusted for gastric cancer risk factors. We present hazard ratios (HR) and 95% confidence intervals (CI) per increase of one daily serving per 1,000 calories. RESULTS: During 2,193,751 person years, 394 participants were diagnosed with incident gastric cancer. We observed no significant associations between total fruit and vegetable intake (1.01, 0.95-1.08), fruit intake (1.04, 0.95-1.14), or vegetable intake (0.98, 0.88-1.08) and gastric cancer risk. Results did not vary by sex or anatomic subsite (cardia versus non-cardia). All 13 botanical subgroups examined had no significant associations with either anatomic sub-site. CONCLUSION: We did not observe significant associations between overall fruit and vegetable intake and gastric cancer risk in this large prospective cohort study. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/18166992/Fruit_and_vegetable_intake_and_gastric_cancer_risk_in_a_large_United_States_prospective_cohort_study_ L2 - https://doi.org/10.1007/s10552-007-9107-4 DB - PRIME DP - Unbound Medicine ER -