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Incidence of age-related cataract over a 15-year interval the Beaver Dam Eye Study.
Ophthalmology. 2008 Mar; 115(3):477-82.O

Abstract

OBJECTIVE

To describe the long-term incidence of nuclear cataract, cortical cataract, and posterior subcapsular cataract (PSC) and to evaluate age and cohort effects on these rates.

DESIGN

Population-based study.

PARTICIPANTS

Members of the Beaver Dam Eye Study cohort.

METHODS

Subjects were seen in study offices for examinations (slit lamp, checking for occludable angles, dilation of pupils, lens photographs, measurement of blood pressures, and study interview).

MAIN OUTCOME MEASURES

Lens photographs were taken with specially modified cameras that have been maintained over the course of all study examinations. Photographs were graded according to standard protocols that have been continued throughout all the examinations.

RESULTS

Cumulative incidence of nuclear cataract was 29.7% (95% confidence interval [CI], 28.0-31.4); cortical cataract, 22.9% (95% CI, 21.3-24.5); PSC, 8.4% (95% CI, 7.4-9.4); and cataract surgery, 17.7% (95% CI, 16.4-19.0). The cumulative incidence increased with age and was greater for women after accounting for competing events. The relationship between age and incidence of cataracts was quadratic for nuclear cataract, cubic for cortical cataract, and linear for PSC. For persons with similar ages at time of examination, those in more recent birth cohorts were less likely to have any type of prevalent cataract; the effect was significant for nuclear cataract and for cataract surgery, and the effect persisted after controlling for relevant confounders. There were apparent cohort effects on cataract incidence.

CONCLUSIONS

Age-adjusted incidence of all cataract types increased with increasing age, although the age effect was not linear for all 3 types. More recent birth cohorts are relatively protected relative to persons born earlier. Further follow-up is needed to verify the trends we report here and to determine whether cohort effects on 10-year incidence are significant.

Authors+Show Affiliations

Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53726, USA. kleinb@epi.ophth.wisc.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18171585

Citation

Klein, Barbara E K., et al. "Incidence of Age-related Cataract Over a 15-year Interval the Beaver Dam Eye Study." Ophthalmology, vol. 115, no. 3, 2008, pp. 477-82.
Klein BE, Klein R, Lee KE, et al. Incidence of age-related cataract over a 15-year interval the Beaver Dam Eye Study. Ophthalmology. 2008;115(3):477-82.
Klein, B. E., Klein, R., Lee, K. E., & Gangnon, R. E. (2008). Incidence of age-related cataract over a 15-year interval the Beaver Dam Eye Study. Ophthalmology, 115(3), 477-82. https://doi.org/10.1016/j.ophtha.2007.11.024
Klein BE, et al. Incidence of Age-related Cataract Over a 15-year Interval the Beaver Dam Eye Study. Ophthalmology. 2008;115(3):477-82. PubMed PMID: 18171585.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Incidence of age-related cataract over a 15-year interval the Beaver Dam Eye Study. AU - Klein,Barbara E K, AU - Klein,Ronald, AU - Lee,Kristine E, AU - Gangnon,Ronald E, Y1 - 2008/01/02/ PY - 2006/11/15/received PY - 2006/11/19/revised PY - 2006/11/20/accepted PY - 2008/1/4/pubmed PY - 2008/3/21/medline PY - 2008/1/4/entrez SP - 477 EP - 82 JF - Ophthalmology JO - Ophthalmology VL - 115 IS - 3 N2 - OBJECTIVE: To describe the long-term incidence of nuclear cataract, cortical cataract, and posterior subcapsular cataract (PSC) and to evaluate age and cohort effects on these rates. DESIGN: Population-based study. PARTICIPANTS: Members of the Beaver Dam Eye Study cohort. METHODS: Subjects were seen in study offices for examinations (slit lamp, checking for occludable angles, dilation of pupils, lens photographs, measurement of blood pressures, and study interview). MAIN OUTCOME MEASURES: Lens photographs were taken with specially modified cameras that have been maintained over the course of all study examinations. Photographs were graded according to standard protocols that have been continued throughout all the examinations. RESULTS: Cumulative incidence of nuclear cataract was 29.7% (95% confidence interval [CI], 28.0-31.4); cortical cataract, 22.9% (95% CI, 21.3-24.5); PSC, 8.4% (95% CI, 7.4-9.4); and cataract surgery, 17.7% (95% CI, 16.4-19.0). The cumulative incidence increased with age and was greater for women after accounting for competing events. The relationship between age and incidence of cataracts was quadratic for nuclear cataract, cubic for cortical cataract, and linear for PSC. For persons with similar ages at time of examination, those in more recent birth cohorts were less likely to have any type of prevalent cataract; the effect was significant for nuclear cataract and for cataract surgery, and the effect persisted after controlling for relevant confounders. There were apparent cohort effects on cataract incidence. CONCLUSIONS: Age-adjusted incidence of all cataract types increased with increasing age, although the age effect was not linear for all 3 types. More recent birth cohorts are relatively protected relative to persons born earlier. Further follow-up is needed to verify the trends we report here and to determine whether cohort effects on 10-year incidence are significant. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/18171585/Incidence_of_age_related_cataract_over_a_15_year_interval_the_Beaver_Dam_Eye_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(07)01274-2 DB - PRIME DP - Unbound Medicine ER -