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Inflammatory markers, insulin resistance and carotid intima-media thickness in North-Indian type 2 diabetic subjects.
J Assoc Physicians India. 2007 Oct; 55:693-9.JA

Abstract

OBJECTIVE

To study the interrelationship of the inflammation, insulin resistance and atherosclerosis in recently diagnosed type 2 diabetes.

METHODOLOGY

Eighty-one newly diagnosed type 2 diabetic patients were compared with 81 healthy age, sex and BMI matched controls. Plasma glucose and insulin (fasting and after 2 hours of 75 gm of oral glucose), lipids and serum levels of C-reactive protein (CRP), fibrinogen and Tumour Necrosis Factor (TNF)-alpha were measured. Carotid (Intima-Medial Thickness) IMT was measured using high "resolution B-Mode ultrasonography. Insulin resistance was calculated using HOMA-IR model. Electrocardiogram (ECG) and exercise ECG were recorded for the evidence of coronary heart disease (CHD).

RESULTS

Carotid IMT was significantly thicker in diabetic patients than in control group across the whole age range (p < 0.01). In merged group of diabetes, composite IMT was significantly correlated with LDL-cholesterol, fasting insulin, serum cholesterol, BMI and HOMA-IR (p < 0.01). After controlling for age and sex, all glycaemic parameters were correlated with IMT in both diabetic and control group. HOMA-IR, waist hip ratio, serum triglycerides, serum cholesterol, fasting serum insulin and CRP were significant predictor of IMT. Concentrations of inflammatory markers were significantly higher in diabetic patients than in control group. Serum levels of CRP (p < 0.05) were found to be higher in diabetic patients with CHD than without CHD. CRP was significantly correlated with IMT (r = 0.603, p < 0.01) in diabetic subjects with and without CHD after controlling for age and sex.

CONCLUSION

Inflammatory markers are associated with type 2 diabetes but only CRP is associated with development of accelerated atherosclerosis and subsequent CHD.

Authors+Show Affiliations

Endocrinology Division, Department of Medicine, J.N. Medical College, Aligarh Muslim University, Aligarh-202002, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18173021

Citation

Ahmad, J, et al. "Inflammatory Markers, Insulin Resistance and Carotid Intima-media Thickness in North-Indian Type 2 Diabetic Subjects." The Journal of the Association of Physicians of India, vol. 55, 2007, pp. 693-9.
Ahmad J, Ahmned F, Siddiqui MA, et al. Inflammatory markers, insulin resistance and carotid intima-media thickness in North-Indian type 2 diabetic subjects. J Assoc Physicians India. 2007;55:693-9.
Ahmad, J., Ahmned, F., Siddiqui, M. A., Khan, A. R., Katyal, P., Hameed, B., & Ahmad, I. (2007). Inflammatory markers, insulin resistance and carotid intima-media thickness in North-Indian type 2 diabetic subjects. The Journal of the Association of Physicians of India, 55, 693-9.
Ahmad J, et al. Inflammatory Markers, Insulin Resistance and Carotid Intima-media Thickness in North-Indian Type 2 Diabetic Subjects. J Assoc Physicians India. 2007;55:693-9. PubMed PMID: 18173021.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inflammatory markers, insulin resistance and carotid intima-media thickness in North-Indian type 2 diabetic subjects. AU - Ahmad,J, AU - Ahmned,Faiz, AU - Siddiqui,M A, AU - Khan,A R, AU - Katyal,P, AU - Hameed,B, AU - Ahmad,I, PY - 2008/1/5/pubmed PY - 2008/1/26/medline PY - 2008/1/5/entrez SP - 693 EP - 9 JF - The Journal of the Association of Physicians of India JO - J Assoc Physicians India VL - 55 N2 - OBJECTIVE: To study the interrelationship of the inflammation, insulin resistance and atherosclerosis in recently diagnosed type 2 diabetes. METHODOLOGY: Eighty-one newly diagnosed type 2 diabetic patients were compared with 81 healthy age, sex and BMI matched controls. Plasma glucose and insulin (fasting and after 2 hours of 75 gm of oral glucose), lipids and serum levels of C-reactive protein (CRP), fibrinogen and Tumour Necrosis Factor (TNF)-alpha were measured. Carotid (Intima-Medial Thickness) IMT was measured using high "resolution B-Mode ultrasonography. Insulin resistance was calculated using HOMA-IR model. Electrocardiogram (ECG) and exercise ECG were recorded for the evidence of coronary heart disease (CHD). RESULTS: Carotid IMT was significantly thicker in diabetic patients than in control group across the whole age range (p < 0.01). In merged group of diabetes, composite IMT was significantly correlated with LDL-cholesterol, fasting insulin, serum cholesterol, BMI and HOMA-IR (p < 0.01). After controlling for age and sex, all glycaemic parameters were correlated with IMT in both diabetic and control group. HOMA-IR, waist hip ratio, serum triglycerides, serum cholesterol, fasting serum insulin and CRP were significant predictor of IMT. Concentrations of inflammatory markers were significantly higher in diabetic patients than in control group. Serum levels of CRP (p < 0.05) were found to be higher in diabetic patients with CHD than without CHD. CRP was significantly correlated with IMT (r = 0.603, p < 0.01) in diabetic subjects with and without CHD after controlling for age and sex. CONCLUSION: Inflammatory markers are associated with type 2 diabetes but only CRP is associated with development of accelerated atherosclerosis and subsequent CHD. SN - 0004-5772 UR - https://www.unboundmedicine.com/medline/citation/18173021/Inflammatory_markers_insulin_resistance_and_carotid_intima_media_thickness_in_North_Indian_type_2_diabetic_subjects_ L2 - https://medlineplus.gov/carotidarterydisease.html DB - PRIME DP - Unbound Medicine ER -