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Cyclooxygenase-2 Gene-765 single nucleotide polymorphism as a protective factor against periodontitis in Taiwanese.
J Clin Periodontol. 2008 Jan; 35(1):1-8.JC

Abstract

AIM

Prostaglandin E(2) (PGE(2)) is considered to be an important mediator of tissue destruction in periodontitis. The cyclooxygenase (COX) catalyses the production of PGs. COX-2, which is induced in an inflammatory response, is responsible for PGs synthesis at sites of inflammation. A single nucleotide polymorphism of COX-2(-765) has been shown to alter the expression of the COX-2 gene. The purpose of the present study was to evaluate the association of the COX-2(-765) polymorphism and susceptibility to periodontitis in Taiwanese.

MATERIAL AND METHODS

Eighty-five cases of aggressive periodontitis (AgP), 343 cases of chronic periodontitis (CP) and 153 cases of healthy controls (HC) were recruited for the study. Genotypes of COX-2(-765) were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The distribution of genotypes among groups was compared by logistic regression analyses. The risk for periodontitis associated with genotypes was calculated as the odds ratio (OR).

RESULTS

The prevalence of the GC and CC genotypes was significantly lower in AgP (5%) and in CP (29%) compared with the HC (42%). The ORs for carriage of the -765C allele (GC+CC versus GG) in AgP and CP were 0.068 (95% CI=0.020-0.173, p<0.0001) and 0.571 (95% CI=0.385-0.849, p=0.006), respectively. After adjustment for age, gender and smoking status, the OR was 0.071 (95% CI=0.017-0.219) and 0.552 (95% CI=0.367-0.829) for AgP and CP, respectively.

CONCLUSIONS

The results of the study suggest that the -765G to C polymorphism of the COX-2 gene is associated with a decreased risk for periodontitis in Taiwanese, especially in AgP. However, the biological meaning needs further investigation.

Authors+Show Affiliations

Faculty of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18173398

Citation

Ho, Ya-Ping, et al. "Cyclooxygenase-2 Gene-765 Single Nucleotide Polymorphism as a Protective Factor Against Periodontitis in Taiwanese." Journal of Clinical Periodontology, vol. 35, no. 1, 2008, pp. 1-8.
Ho YP, Lin YC, Yang YH, et al. Cyclooxygenase-2 Gene-765 single nucleotide polymorphism as a protective factor against periodontitis in Taiwanese. J Clin Periodontol. 2008;35(1):1-8.
Ho, Y. P., Lin, Y. C., Yang, Y. H., Ho, K. Y., Wu, Y. M., & Tsai, C. C. (2008). Cyclooxygenase-2 Gene-765 single nucleotide polymorphism as a protective factor against periodontitis in Taiwanese. Journal of Clinical Periodontology, 35(1), 1-8. https://doi.org/10.1111/j.1600-051X.2007.01167.x
Ho YP, et al. Cyclooxygenase-2 Gene-765 Single Nucleotide Polymorphism as a Protective Factor Against Periodontitis in Taiwanese. J Clin Periodontol. 2008;35(1):1-8. PubMed PMID: 18173398.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cyclooxygenase-2 Gene-765 single nucleotide polymorphism as a protective factor against periodontitis in Taiwanese. AU - Ho,Ya-Ping, AU - Lin,Ying-Chu, AU - Yang,Yi-Hsin, AU - Ho,Kun-Yen, AU - Wu,Yi-Min, AU - Tsai,Chi-Cheng, PY - 2008/1/5/pubmed PY - 2008/3/19/medline PY - 2008/1/5/entrez SP - 1 EP - 8 JF - Journal of clinical periodontology JO - J Clin Periodontol VL - 35 IS - 1 N2 - AIM: Prostaglandin E(2) (PGE(2)) is considered to be an important mediator of tissue destruction in periodontitis. The cyclooxygenase (COX) catalyses the production of PGs. COX-2, which is induced in an inflammatory response, is responsible for PGs synthesis at sites of inflammation. A single nucleotide polymorphism of COX-2(-765) has been shown to alter the expression of the COX-2 gene. The purpose of the present study was to evaluate the association of the COX-2(-765) polymorphism and susceptibility to periodontitis in Taiwanese. MATERIAL AND METHODS: Eighty-five cases of aggressive periodontitis (AgP), 343 cases of chronic periodontitis (CP) and 153 cases of healthy controls (HC) were recruited for the study. Genotypes of COX-2(-765) were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The distribution of genotypes among groups was compared by logistic regression analyses. The risk for periodontitis associated with genotypes was calculated as the odds ratio (OR). RESULTS: The prevalence of the GC and CC genotypes was significantly lower in AgP (5%) and in CP (29%) compared with the HC (42%). The ORs for carriage of the -765C allele (GC+CC versus GG) in AgP and CP were 0.068 (95% CI=0.020-0.173, p<0.0001) and 0.571 (95% CI=0.385-0.849, p=0.006), respectively. After adjustment for age, gender and smoking status, the OR was 0.071 (95% CI=0.017-0.219) and 0.552 (95% CI=0.367-0.829) for AgP and CP, respectively. CONCLUSIONS: The results of the study suggest that the -765G to C polymorphism of the COX-2 gene is associated with a decreased risk for periodontitis in Taiwanese, especially in AgP. However, the biological meaning needs further investigation. SN - 1600-051X UR - https://www.unboundmedicine.com/medline/citation/18173398/Cyclooxygenase_2_Gene_765_single_nucleotide_polymorphism_as_a_protective_factor_against_periodontitis_in_Taiwanese_ L2 - https://doi.org/10.1111/j.1600-051X.2007.01167.x DB - PRIME DP - Unbound Medicine ER -