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Antidepressant-like effects of the novel kappa opioid antagonist MCL-144B in the forced-swim test.
Pharmacology. 2008; 81(3):229-35.P

Abstract

Previous studies have demonstrated that kappa opioid receptor (KOR) antagonists reduce stress- and depression-like behaviors. We hypothesized that administration of a novel opioid mixed agonist/antagonist capable of antagonist activity at the KOR would attenuate forced-swim stress (FSS)-induced immobility, an animal model of depression-like behavior. C57Bl/6J mice were exposed to antinociceptive and repeated FSS testing after pretreatment with a graded dose of a novel bivalent morphinan compound, bis(N-cyclobutylmethylmorphinan-3-yl) sebacoylate dihydrochloride (MCL-144B). MCL-144B demonstrated dose- and time-dependent antinociception and KOR-mediated antagonism. In support of the hypothesis, pretreatment with MCL-144B dose-dependently attenuated stress-induced antinociception and immobility in the forced-swim test.

Authors+Show Affiliations

Department of Psychology, Northeastern University, Boston, MA 02115, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18176093

Citation

Reindl, J D., et al. "Antidepressant-like Effects of the Novel Kappa Opioid Antagonist MCL-144B in the Forced-swim Test." Pharmacology, vol. 81, no. 3, 2008, pp. 229-35.
Reindl JD, Rowan K, Carey AN, et al. Antidepressant-like effects of the novel kappa opioid antagonist MCL-144B in the forced-swim test. Pharmacology. 2008;81(3):229-35.
Reindl, J. D., Rowan, K., Carey, A. N., Peng, X., Neumeyer, J. L., & McLaughlin, J. P. (2008). Antidepressant-like effects of the novel kappa opioid antagonist MCL-144B in the forced-swim test. Pharmacology, 81(3), 229-35. https://doi.org/10.1159/000112867
Reindl JD, et al. Antidepressant-like Effects of the Novel Kappa Opioid Antagonist MCL-144B in the Forced-swim Test. Pharmacology. 2008;81(3):229-35. PubMed PMID: 18176093.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidepressant-like effects of the novel kappa opioid antagonist MCL-144B in the forced-swim test. AU - Reindl,J D, AU - Rowan,K, AU - Carey,A N, AU - Peng,X, AU - Neumeyer,J L, AU - McLaughlin,J P, Y1 - 2008/01/07/ PY - 2007/07/04/received PY - 2007/09/04/accepted PY - 2008/1/8/pubmed PY - 2008/4/23/medline PY - 2008/1/8/entrez SP - 229 EP - 35 JF - Pharmacology JO - Pharmacology VL - 81 IS - 3 N2 - Previous studies have demonstrated that kappa opioid receptor (KOR) antagonists reduce stress- and depression-like behaviors. We hypothesized that administration of a novel opioid mixed agonist/antagonist capable of antagonist activity at the KOR would attenuate forced-swim stress (FSS)-induced immobility, an animal model of depression-like behavior. C57Bl/6J mice were exposed to antinociceptive and repeated FSS testing after pretreatment with a graded dose of a novel bivalent morphinan compound, bis(N-cyclobutylmethylmorphinan-3-yl) sebacoylate dihydrochloride (MCL-144B). MCL-144B demonstrated dose- and time-dependent antinociception and KOR-mediated antagonism. In support of the hypothesis, pretreatment with MCL-144B dose-dependently attenuated stress-induced antinociception and immobility in the forced-swim test. SN - 1423-0313 UR - https://www.unboundmedicine.com/medline/citation/18176093/Antidepressant_like_effects_of_the_novel_kappa_opioid_antagonist_MCL_144B_in_the_forced_swim_test_ L2 - https://www.karger.com?DOI=10.1159/000112867 DB - PRIME DP - Unbound Medicine ER -