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Levels of trace elements in the serum and erythrocytes and some parameters of erythrocyte heme metabolism (FEP, ALA-D, ALA-U) in copper foundry workers.
Pol J Occup Med Environ Health 1991; 4(4):339-47PJ

Abstract

The study was designed to investigate the usefulness of some biochemical indices for determination of lead toxicity. In exposed and control groups, the following parameters were measured: concentration of lead in the blood, level of free erythrocyte protoporphyrins and delta-aminolevulinic acid dehydratase activity of erythrocytes. Levels of sodium, potassium, calcium, magnesium, copper and zinc in the serum and erythrocytes as well as of iron in the serum were determined. The chelation test was performed and excretion of lead, coproporphyrins and delta-aminolevulinic acid (in 24 hour urine sample before and after EDTA injection) identified only in the exposed group. Absorption of lead was significantly higher in the exposed group (increased blood lead level (Pb-B), free erythrocyte protoporphyrin (FEP) and decreased erythrocyte ALA-dehydratase (ALA-D) activity. Levels of copper and calcium in the serum and red blood cells were significantly lower in comparison with the controls. Iron and sodium concentration in the serum as well as levels of potassium, magnesium and calcium in erythrocytes were significantly higher in the exposed group. The chelation test in the exposed group showed a significantly increased excretion of lead in 24 hour urine sample. Concentration of delta-aminolevulinic acid in 24 hour urine sample was lower after EDTA injection.

Authors+Show Affiliations

Department of Internal and Occupational Diseases, Medical Academy, Wroclaw, Poland.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1817683

Citation

Antonowicz, J, et al. "Levels of Trace Elements in the Serum and Erythrocytes and some Parameters of Erythrocyte Heme Metabolism (FEP, ALA-D, ALA-U) in Copper Foundry Workers." Polish Journal of Occupational Medicine and Environmental Health, vol. 4, no. 4, 1991, pp. 339-47.
Antonowicz J, Andrzejczak R, Kuliczkowski K, et al. Levels of trace elements in the serum and erythrocytes and some parameters of erythrocyte heme metabolism (FEP, ALA-D, ALA-U) in copper foundry workers. Pol J Occup Med Environ Health. 1991;4(4):339-47.
Antonowicz, J., Andrzejczak, R., Kuliczkowski, K., & Smolik, R. (1991). Levels of trace elements in the serum and erythrocytes and some parameters of erythrocyte heme metabolism (FEP, ALA-D, ALA-U) in copper foundry workers. Polish Journal of Occupational Medicine and Environmental Health, 4(4), pp. 339-47.
Antonowicz J, et al. Levels of Trace Elements in the Serum and Erythrocytes and some Parameters of Erythrocyte Heme Metabolism (FEP, ALA-D, ALA-U) in Copper Foundry Workers. Pol J Occup Med Environ Health. 1991;4(4):339-47. PubMed PMID: 1817683.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Levels of trace elements in the serum and erythrocytes and some parameters of erythrocyte heme metabolism (FEP, ALA-D, ALA-U) in copper foundry workers. AU - Antonowicz,J, AU - Andrzejczak,R, AU - Kuliczkowski,K, AU - Smolik,R, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 339 EP - 47 JF - Polish journal of occupational medicine and environmental health JO - Pol J Occup Med Environ Health VL - 4 IS - 4 N2 - The study was designed to investigate the usefulness of some biochemical indices for determination of lead toxicity. In exposed and control groups, the following parameters were measured: concentration of lead in the blood, level of free erythrocyte protoporphyrins and delta-aminolevulinic acid dehydratase activity of erythrocytes. Levels of sodium, potassium, calcium, magnesium, copper and zinc in the serum and erythrocytes as well as of iron in the serum were determined. The chelation test was performed and excretion of lead, coproporphyrins and delta-aminolevulinic acid (in 24 hour urine sample before and after EDTA injection) identified only in the exposed group. Absorption of lead was significantly higher in the exposed group (increased blood lead level (Pb-B), free erythrocyte protoporphyrin (FEP) and decreased erythrocyte ALA-dehydratase (ALA-D) activity. Levels of copper and calcium in the serum and red blood cells were significantly lower in comparison with the controls. Iron and sodium concentration in the serum as well as levels of potassium, magnesium and calcium in erythrocytes were significantly higher in the exposed group. The chelation test in the exposed group showed a significantly increased excretion of lead in 24 hour urine sample. Concentration of delta-aminolevulinic acid in 24 hour urine sample was lower after EDTA injection. SN - 0867-8383 UR - https://www.unboundmedicine.com/medline/citation/1817683/Levels_of_trace_elements_in_the_serum_and_erythrocytes_and_some_parameters_of_erythrocyte_heme_metabolism__FEP_ALA_D_ALA_U__in_copper_foundry_workers_ L2 - https://medlineplus.gov/leadpoisoning.html DB - PRIME DP - Unbound Medicine ER -