Tags

Type your tag names separated by a space and hit enter

Celiac disease in North Italian patients with autoimmune thyroid diseases.

Abstract

BACKGROUND

Patients with autoimmune thyroid diseases (AITDs) are prone to develop other autoimmune manifestations and to display autoimmune polyendocrine syndromes. An increased prevalence of celiac disease (CD) was demonstrated in adult European and Italian patients with AITDs; conversely, an increased prevalence of AITDs was demonstrated in patients with CD. An IgA deficiency is the most frequent immunodeficiency in humans and, in general, high frequency of this disorder was demonstrated in those with autoimmune diseases.

AIM

To define the prevalence of both CD and IgA deficiency in North Italian patients with AITDs.

METHODS

276 Italian patients with AITD were enrolled (mean age 42.6 years range 12-89, 186 of whom had chronic thyroiditis and 90 had Graves' disease). The tissue transglutaminase autoantibodies of the IgA class (IgA-tTGAbs) were evaluated using an ELISA method in these patients. Furthermore, the serological levels of the IgA were determined.

RESULTS

Five of the patients (1.8%) were affected by previously diagnosed CD and were on a gluten-free diet. Ten out of the remaining 271 patients (3.6%) were found to be positive for celiac-related autoantibodies. All of these patients agreed to undergo endoscopy and duodenal biopsies and silent CD was found in 5 of them but 5 had not histopathological signs of CD. CD (clinical, silent or latent) was present in 15/276 (5.4%) of the North Italian patients with AITD; this prevalence is significantly higher with respect to the general population (p < 0.00001). The genetic pattern of the 10 patients with both AITDs and CD was characterized by the presence of DQ2 in 8 patients and DQ8 in 2. An IgA deficiency was present in 2/276 of the patients (0.72%).

CONCLUSIONS

CD is significantly increased in patients with thyroid autoimmune disorders for this reason it is important to screen for CD in patients with AITDs.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Division of Endocrinology, Department of Medical and Surgical Sciences, University of Padova Medical School, Padova, Italy.

    , , , , , , ,

    Source

    Autoimmunity 41:1 2008 Feb pg 116-21

    MeSH

    Adolescent
    Adult
    Aged
    Aged, 80 and over
    Autoantibodies
    Celiac Disease
    Child
    Chronic Disease
    Female
    Graves Disease
    Humans
    IgA Deficiency
    Italy
    Male
    Middle Aged
    Organ Specificity
    Prevalence
    Thyroid Gland
    Thyroiditis, Autoimmune
    Transglutaminases

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    18176874

    Citation

    Spadaccino, Aglaura Cinzia, et al. "Celiac Disease in North Italian Patients With Autoimmune Thyroid Diseases." Autoimmunity, vol. 41, no. 1, 2008, pp. 116-21.
    Spadaccino AC, Basso D, Chiarelli S, et al. Celiac disease in North Italian patients with autoimmune thyroid diseases. Autoimmunity. 2008;41(1):116-21.
    Spadaccino, A. C., Basso, D., Chiarelli, S., Albergoni, M. P., D'Odorico, A., Plebani, M., ... Betterle, C. (2008). Celiac disease in North Italian patients with autoimmune thyroid diseases. Autoimmunity, 41(1), pp. 116-21. doi:10.1080/08916930701620209.
    Spadaccino AC, et al. Celiac Disease in North Italian Patients With Autoimmune Thyroid Diseases. Autoimmunity. 2008;41(1):116-21. PubMed PMID: 18176874.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Celiac disease in North Italian patients with autoimmune thyroid diseases. AU - Spadaccino,Aglaura Cinzia, AU - Basso,Daniela, AU - Chiarelli,Silvia, AU - Albergoni,Maria Paola, AU - D'Odorico,Anna, AU - Plebani,Mario, AU - Pedini,Beniamino, AU - Lazzarotto,Francesca, AU - Betterle,Corrado, PY - 2008/1/8/pubmed PY - 2008/1/23/medline PY - 2008/1/8/entrez SP - 116 EP - 21 JF - Autoimmunity JO - Autoimmunity VL - 41 IS - 1 N2 - BACKGROUND: Patients with autoimmune thyroid diseases (AITDs) are prone to develop other autoimmune manifestations and to display autoimmune polyendocrine syndromes. An increased prevalence of celiac disease (CD) was demonstrated in adult European and Italian patients with AITDs; conversely, an increased prevalence of AITDs was demonstrated in patients with CD. An IgA deficiency is the most frequent immunodeficiency in humans and, in general, high frequency of this disorder was demonstrated in those with autoimmune diseases. AIM: To define the prevalence of both CD and IgA deficiency in North Italian patients with AITDs. METHODS: 276 Italian patients with AITD were enrolled (mean age 42.6 years range 12-89, 186 of whom had chronic thyroiditis and 90 had Graves' disease). The tissue transglutaminase autoantibodies of the IgA class (IgA-tTGAbs) were evaluated using an ELISA method in these patients. Furthermore, the serological levels of the IgA were determined. RESULTS: Five of the patients (1.8%) were affected by previously diagnosed CD and were on a gluten-free diet. Ten out of the remaining 271 patients (3.6%) were found to be positive for celiac-related autoantibodies. All of these patients agreed to undergo endoscopy and duodenal biopsies and silent CD was found in 5 of them but 5 had not histopathological signs of CD. CD (clinical, silent or latent) was present in 15/276 (5.4%) of the North Italian patients with AITD; this prevalence is significantly higher with respect to the general population (p < 0.00001). The genetic pattern of the 10 patients with both AITDs and CD was characterized by the presence of DQ2 in 8 patients and DQ8 in 2. An IgA deficiency was present in 2/276 of the patients (0.72%). CONCLUSIONS: CD is significantly increased in patients with thyroid autoimmune disorders for this reason it is important to screen for CD in patients with AITDs. SN - 1607-842X UR - https://www.unboundmedicine.com/medline/citation/18176874/Celiac_disease_in_North_Italian_patients_with_autoimmune_thyroid_diseases_ L2 - http://www.tandfonline.com/doi/full/10.1080/08916930701620209 DB - PRIME DP - Unbound Medicine ER -