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Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum.
Cell Metab. 2008 Jan; 7(1):79-85.CM

Abstract

Iron regulatory proteins (IRPs) orchestrate the posttranscriptional regulation of critical iron metabolism proteins at the cellular level. Redundancy between IRP1 and IRP2 associated with embryonic lethality of doubly IRP-deficient mice has precluded the study of IRP function in vivo. Here we use Cre/Lox technology to generate viable organisms lacking IRP expression in a single tissue, the intestine. Mice lacking intestinal IRP expression develop intestinal malabsorption and dehydration postnatally and die within 4 weeks of birth. We demonstrate that IRPs control the expression of divalent metal transporter 1 (DMT1) mRNA and protein, a limiting intestinal iron importer. IRPs are also shown to be critically important to secure physiological levels of the basolateral iron exporter ferroportin. IRPs are thus essential for intestinal function and organismal survival and coordinate the synthesis of key iron metabolism proteins in the duodenum.

Authors+Show Affiliations

European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18177727

Citation

Galy, Bruno, et al. "Iron Regulatory Proteins Are Essential for Intestinal Function and Control Key Iron Absorption Molecules in the Duodenum." Cell Metabolism, vol. 7, no. 1, 2008, pp. 79-85.
Galy B, Ferring-Appel D, Kaden S, et al. Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum. Cell Metab. 2008;7(1):79-85.
Galy, B., Ferring-Appel, D., Kaden, S., Gröne, H. J., & Hentze, M. W. (2008). Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum. Cell Metabolism, 7(1), 79-85. https://doi.org/10.1016/j.cmet.2007.10.006
Galy B, et al. Iron Regulatory Proteins Are Essential for Intestinal Function and Control Key Iron Absorption Molecules in the Duodenum. Cell Metab. 2008;7(1):79-85. PubMed PMID: 18177727.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum. AU - Galy,Bruno, AU - Ferring-Appel,Dunja, AU - Kaden,Sylvia, AU - Gröne,Hermann-Josef, AU - Hentze,Matthias W, PY - 2007/07/26/received PY - 2007/09/24/revised PY - 2007/10/12/accepted PY - 2008/1/8/pubmed PY - 2008/5/31/medline PY - 2008/1/8/entrez SP - 79 EP - 85 JF - Cell metabolism JO - Cell Metab VL - 7 IS - 1 N2 - Iron regulatory proteins (IRPs) orchestrate the posttranscriptional regulation of critical iron metabolism proteins at the cellular level. Redundancy between IRP1 and IRP2 associated with embryonic lethality of doubly IRP-deficient mice has precluded the study of IRP function in vivo. Here we use Cre/Lox technology to generate viable organisms lacking IRP expression in a single tissue, the intestine. Mice lacking intestinal IRP expression develop intestinal malabsorption and dehydration postnatally and die within 4 weeks of birth. We demonstrate that IRPs control the expression of divalent metal transporter 1 (DMT1) mRNA and protein, a limiting intestinal iron importer. IRPs are also shown to be critically important to secure physiological levels of the basolateral iron exporter ferroportin. IRPs are thus essential for intestinal function and organismal survival and coordinate the synthesis of key iron metabolism proteins in the duodenum. SN - 1550-4131 UR - https://www.unboundmedicine.com/medline/citation/18177727/Iron_regulatory_proteins_are_essential_for_intestinal_function_and_control_key_iron_absorption_molecules_in_the_duodenum_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1550-4131(07)00299-9 DB - PRIME DP - Unbound Medicine ER -