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The association of pre-conization high-risk HPV load and the persistence of HPV infection and persistence/recurrence of cervical intraepithelial neoplasia after conization.
Gynecol Oncol 2008; 108(3):549-54GO

Abstract

OBJECTIVE

The aim of this study was to evaluate whether the pre-conization high-risk human papilloma virus (HR-HPV) load is predictive for the persistence of HR-HPV infection and the persistence/recurrence of cervical intraepithelial neoplasia (CIN) after conization of the cervix.

MATERIALS AND METHODS

A retrospective review was performed on 236 women who underwent conization due to CIN at the Center for Uterine Cancer, National Cancer Center, Korea, between March 2001 and March 2006. The samples for pre-conization HR-HPV test were obtained at least within 3 weeks before conization. All patients underwent HR-HPV testing and cytology between 3 and 6 months after conization, and subsequent follow-up of 3- to 6-month interval was performed thereafter. The persistence of HR-HPV infection and persistence/recurrence of histologic abnormality after conization were analyzed by age, parity, menopausal status, method of conization, glandular extension, margin status, severity of CIN, and pre-cone HR-HPV load in univariate and multivariate analysis.

RESULTS

In univariate analysis, high pre-cone HR-HPV load was the only risk factor for the persistence of HR-HPV infection after conization (persistent HR-HPV infection; 19.8% [23/116] of patients with an HR-HPV load > or = 100 RLU/PC vs. 10.0% [12/120] of patients with a load < 100 RLU/PC, P=0.034). Multivariate analysis showed that an HR-HPV load > or = 100 RLU/PC was a risk factor for persistence/recurrence of histological abnormalities after conization (P=0.040, OR=5.748, 95% CI=1.082-30.526).

CONCLUSION

Patients with a pre-conization HR-HPV load > or = 100 RLU/PC had a higher rate of persistent HR-HPV infection and a higher rate of persistent/recurrent histological abnormalities after conization for CIN compared to patients with a load < 100 RLU/PC.

Authors+Show Affiliations

Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, 809 Madu1-dong, Ilsan-gu, Goyang-si, Gyeonggi-do, 411-351, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18177929

Citation

Park, Jeong-Yeol, et al. "The Association of Pre-conization High-risk HPV Load and the Persistence of HPV Infection and Persistence/recurrence of Cervical Intraepithelial Neoplasia After Conization." Gynecologic Oncology, vol. 108, no. 3, 2008, pp. 549-54.
Park JY, Lee KH, Dong SM, et al. The association of pre-conization high-risk HPV load and the persistence of HPV infection and persistence/recurrence of cervical intraepithelial neoplasia after conization. Gynecol Oncol. 2008;108(3):549-54.
Park, J. Y., Lee, K. H., Dong, S. M., Kang, S., Park, S. Y., & Seo, S. S. (2008). The association of pre-conization high-risk HPV load and the persistence of HPV infection and persistence/recurrence of cervical intraepithelial neoplasia after conization. Gynecologic Oncology, 108(3), pp. 549-54. doi:10.1016/j.ygyno.2007.11.009.
Park JY, et al. The Association of Pre-conization High-risk HPV Load and the Persistence of HPV Infection and Persistence/recurrence of Cervical Intraepithelial Neoplasia After Conization. Gynecol Oncol. 2008;108(3):549-54. PubMed PMID: 18177929.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association of pre-conization high-risk HPV load and the persistence of HPV infection and persistence/recurrence of cervical intraepithelial neoplasia after conization. AU - Park,Jeong-Yeol, AU - Lee,Kyung Hee, AU - Dong,Seung Myung, AU - Kang,Sokbom, AU - Park,Sang-Yoon, AU - Seo,Sang-Soo, Y1 - 2008/01/04/ PY - 2007/08/16/received PY - 2007/11/08/revised PY - 2007/11/14/accepted PY - 2008/1/8/pubmed PY - 2008/3/21/medline PY - 2008/1/8/entrez SP - 549 EP - 54 JF - Gynecologic oncology JO - Gynecol. Oncol. VL - 108 IS - 3 N2 - OBJECTIVE: The aim of this study was to evaluate whether the pre-conization high-risk human papilloma virus (HR-HPV) load is predictive for the persistence of HR-HPV infection and the persistence/recurrence of cervical intraepithelial neoplasia (CIN) after conization of the cervix. MATERIALS AND METHODS: A retrospective review was performed on 236 women who underwent conization due to CIN at the Center for Uterine Cancer, National Cancer Center, Korea, between March 2001 and March 2006. The samples for pre-conization HR-HPV test were obtained at least within 3 weeks before conization. All patients underwent HR-HPV testing and cytology between 3 and 6 months after conization, and subsequent follow-up of 3- to 6-month interval was performed thereafter. The persistence of HR-HPV infection and persistence/recurrence of histologic abnormality after conization were analyzed by age, parity, menopausal status, method of conization, glandular extension, margin status, severity of CIN, and pre-cone HR-HPV load in univariate and multivariate analysis. RESULTS: In univariate analysis, high pre-cone HR-HPV load was the only risk factor for the persistence of HR-HPV infection after conization (persistent HR-HPV infection; 19.8% [23/116] of patients with an HR-HPV load > or = 100 RLU/PC vs. 10.0% [12/120] of patients with a load < 100 RLU/PC, P=0.034). Multivariate analysis showed that an HR-HPV load > or = 100 RLU/PC was a risk factor for persistence/recurrence of histological abnormalities after conization (P=0.040, OR=5.748, 95% CI=1.082-30.526). CONCLUSION: Patients with a pre-conization HR-HPV load > or = 100 RLU/PC had a higher rate of persistent HR-HPV infection and a higher rate of persistent/recurrent histological abnormalities after conization for CIN compared to patients with a load < 100 RLU/PC. SN - 1095-6859 UR - https://www.unboundmedicine.com/medline/citation/18177929/The_association_of_pre_conization_high_risk_HPV_load_and_the_persistence_of_HPV_infection_and_persistence/recurrence_of_cervical_intraepithelial_neoplasia_after_conization_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-8258(07)00910-9 DB - PRIME DP - Unbound Medicine ER -