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Calcium-dependent mechanisms of the reinstatement of nicotine-conditioned place preference by drug priming in rats.
Pharmacol Biochem Behav. 2008 Mar; 89(1):116-25.PB

Abstract

Reinstatement of drug-seeking behaviour in animals is relevant to relapse to drug taking in humans. We used the conditioned place preference version of the reinstatement model to investigate the establishment, extinction, reinstatement and cross-reinstatement of nicotine-induced place conditioning in rats. Nicotine produced a place preference to the compartment paired with its injections during conditioning (0.5 mg/kg, i.p., three drug sessions). Once established, nicotine place preference was extinguished by repeated training. Following this extinction phase, nicotine-experienced rats were challenged with nicotine (0.5 mg/kg, i.p.), a cannabinoid receptor agonist WIN55,212-2 (0.5 mg/kg, i.p.), ethanol (0.5 g/kg, i.p.) or d-amphetamine (2 mg/kg, i.p.). The priming injections of nicotine, WIN55,212-2 and ethanol, but not of d-amphetamine renewed a preference for the compartment previously paired with nicotine. Finally, we examined the influence of the calcium channel antagonists, nimodipine (5 and 10 mg/kg, i.p.) and flunarizine (5 and 10 mg/kg, i.p.), on the reinstatement of nicotine place conditioning induced by WIN55,212-2 and ethanol. It was shown that the calcium channel blockers attenuated the reinstatement of nicotine-conditioned response induced by both drugs. As reinstatement of drug-seeking is a factor for the development of dependence, the L-type calcium channel antagonists may be useful in the relapse-prevention phase of addiction treatment, including cannabinoid, ethanol, and/or nicotine dependence.

Authors+Show Affiliations

Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, 4 Staszica Street, 20-081 Lublin, Poland. grazyna.biala@am.lublin.pl <grazyna.biala@am.lublin.pl>No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18178244

Citation

Biala, G, and B Budzynska. "Calcium-dependent Mechanisms of the Reinstatement of Nicotine-conditioned Place Preference By Drug Priming in Rats." Pharmacology, Biochemistry, and Behavior, vol. 89, no. 1, 2008, pp. 116-25.
Biala G, Budzynska B. Calcium-dependent mechanisms of the reinstatement of nicotine-conditioned place preference by drug priming in rats. Pharmacol Biochem Behav. 2008;89(1):116-25.
Biala, G., & Budzynska, B. (2008). Calcium-dependent mechanisms of the reinstatement of nicotine-conditioned place preference by drug priming in rats. Pharmacology, Biochemistry, and Behavior, 89(1), 116-25. https://doi.org/10.1016/j.pbb.2007.12.005
Biala G, Budzynska B. Calcium-dependent Mechanisms of the Reinstatement of Nicotine-conditioned Place Preference By Drug Priming in Rats. Pharmacol Biochem Behav. 2008;89(1):116-25. PubMed PMID: 18178244.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Calcium-dependent mechanisms of the reinstatement of nicotine-conditioned place preference by drug priming in rats. AU - Biala,G, AU - Budzynska,B, Y1 - 2007/12/10/ PY - 2007/09/07/received PY - 2007/11/28/revised PY - 2007/12/03/accepted PY - 2008/1/8/pubmed PY - 2008/4/10/medline PY - 2008/1/8/entrez SP - 116 EP - 25 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol Biochem Behav VL - 89 IS - 1 N2 - Reinstatement of drug-seeking behaviour in animals is relevant to relapse to drug taking in humans. We used the conditioned place preference version of the reinstatement model to investigate the establishment, extinction, reinstatement and cross-reinstatement of nicotine-induced place conditioning in rats. Nicotine produced a place preference to the compartment paired with its injections during conditioning (0.5 mg/kg, i.p., three drug sessions). Once established, nicotine place preference was extinguished by repeated training. Following this extinction phase, nicotine-experienced rats were challenged with nicotine (0.5 mg/kg, i.p.), a cannabinoid receptor agonist WIN55,212-2 (0.5 mg/kg, i.p.), ethanol (0.5 g/kg, i.p.) or d-amphetamine (2 mg/kg, i.p.). The priming injections of nicotine, WIN55,212-2 and ethanol, but not of d-amphetamine renewed a preference for the compartment previously paired with nicotine. Finally, we examined the influence of the calcium channel antagonists, nimodipine (5 and 10 mg/kg, i.p.) and flunarizine (5 and 10 mg/kg, i.p.), on the reinstatement of nicotine place conditioning induced by WIN55,212-2 and ethanol. It was shown that the calcium channel blockers attenuated the reinstatement of nicotine-conditioned response induced by both drugs. As reinstatement of drug-seeking is a factor for the development of dependence, the L-type calcium channel antagonists may be useful in the relapse-prevention phase of addiction treatment, including cannabinoid, ethanol, and/or nicotine dependence. SN - 0091-3057 UR - https://www.unboundmedicine.com/medline/citation/18178244/Calcium_dependent_mechanisms_of_the_reinstatement_of_nicotine_conditioned_place_preference_by_drug_priming_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(07)00354-1 DB - PRIME DP - Unbound Medicine ER -