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Higher levels of inflammation factors and greater insulin resistance are independently associated with higher heart rate and lower heart rate variability in normoglycemic older individuals: the Cardiovascular Health Study.
J Am Geriatr Soc. 2008 Feb; 56(2):315-21.JA

Abstract

OBJECTIVES

To explore the relationship between (1) insulin resistance and inflammation factors with (2) higher heart rate (HR) and lower heart rate variability (HRV) in normoglycemic older adults.

DESIGN

Cross-sectional population-based study.

PARTICIPANTS

Five hundred forty-five adults aged 65 and older with normoglycemia (fasting glucose <100 mg/dL) who participated in the Cardiovascular Health Study.

MEASUREMENTS

Serum levels of three inflammation proteins (C-reactive protein (CRP), interleukin 6 (IL-6), and fibrinogen); insulin resistance, quantified according to the homeostasis assessment model (HOMA-IR); HR; and four representative measures of HRV (the standard deviation of normal beat to beat intervals (SDNN), the root mean square of successive differences (rMSSD), very low frequency power (VLF), and the low- to high-frequency power ratio (LF/HF)) derived from 24-hour Holter recordings.

RESULTS

High CRP and IL-6 levels were associated with higher HR and lower SDNN and VLF after adjustment for multiple covariates, including HOMA-IR and clinical cardiovascular disease. High IL-6 was also associated with lower LF/HF. Significant univariate inverse relationships between HOMA-IR and HR and HRV were also found, but the strengths of these relationships were attenuated after adjustment for inflammation factors.

CONCLUSION

Increased levels of inflammation markers and HOMA-IR are associated with higher HR and lower HRV. These findings suggest that inflammation may contribute to the pathogenesis of cardiovascular autonomic decline in older adults.

Authors+Show Affiliations

Cardiovascular Division, Washington University School of Medicine, St. Louis, Missouri 63108, USA. pstein@im.wustl.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18179502

Citation

Stein, Phyllis K., et al. "Higher Levels of Inflammation Factors and Greater Insulin Resistance Are Independently Associated With Higher Heart Rate and Lower Heart Rate Variability in Normoglycemic Older Individuals: the Cardiovascular Health Study." Journal of the American Geriatrics Society, vol. 56, no. 2, 2008, pp. 315-21.
Stein PK, Barzilay JI, Chaves PH, et al. Higher levels of inflammation factors and greater insulin resistance are independently associated with higher heart rate and lower heart rate variability in normoglycemic older individuals: the Cardiovascular Health Study. J Am Geriatr Soc. 2008;56(2):315-21.
Stein, P. K., Barzilay, J. I., Chaves, P. H., Traber, J., Domitrovich, P. P., Heckbert, S. R., & Gottdiener, J. S. (2008). Higher levels of inflammation factors and greater insulin resistance are independently associated with higher heart rate and lower heart rate variability in normoglycemic older individuals: the Cardiovascular Health Study. Journal of the American Geriatrics Society, 56(2), 315-21. https://doi.org/10.1111/j.1532-5415.2007.01564.x
Stein PK, et al. Higher Levels of Inflammation Factors and Greater Insulin Resistance Are Independently Associated With Higher Heart Rate and Lower Heart Rate Variability in Normoglycemic Older Individuals: the Cardiovascular Health Study. J Am Geriatr Soc. 2008;56(2):315-21. PubMed PMID: 18179502.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Higher levels of inflammation factors and greater insulin resistance are independently associated with higher heart rate and lower heart rate variability in normoglycemic older individuals: the Cardiovascular Health Study. AU - Stein,Phyllis K, AU - Barzilay,Joshua I, AU - Chaves,Paulo H M, AU - Traber,Jennifer, AU - Domitrovich,Peter P, AU - Heckbert,Susan R, AU - Gottdiener,John S, Y1 - 2008/01/04/ PY - 2008/1/9/pubmed PY - 2008/3/7/medline PY - 2008/1/9/entrez SP - 315 EP - 21 JF - Journal of the American Geriatrics Society JO - J Am Geriatr Soc VL - 56 IS - 2 N2 - OBJECTIVES: To explore the relationship between (1) insulin resistance and inflammation factors with (2) higher heart rate (HR) and lower heart rate variability (HRV) in normoglycemic older adults. DESIGN: Cross-sectional population-based study. PARTICIPANTS: Five hundred forty-five adults aged 65 and older with normoglycemia (fasting glucose <100 mg/dL) who participated in the Cardiovascular Health Study. MEASUREMENTS: Serum levels of three inflammation proteins (C-reactive protein (CRP), interleukin 6 (IL-6), and fibrinogen); insulin resistance, quantified according to the homeostasis assessment model (HOMA-IR); HR; and four representative measures of HRV (the standard deviation of normal beat to beat intervals (SDNN), the root mean square of successive differences (rMSSD), very low frequency power (VLF), and the low- to high-frequency power ratio (LF/HF)) derived from 24-hour Holter recordings. RESULTS: High CRP and IL-6 levels were associated with higher HR and lower SDNN and VLF after adjustment for multiple covariates, including HOMA-IR and clinical cardiovascular disease. High IL-6 was also associated with lower LF/HF. Significant univariate inverse relationships between HOMA-IR and HR and HRV were also found, but the strengths of these relationships were attenuated after adjustment for inflammation factors. CONCLUSION: Increased levels of inflammation markers and HOMA-IR are associated with higher HR and lower HRV. These findings suggest that inflammation may contribute to the pathogenesis of cardiovascular autonomic decline in older adults. SN - 1532-5415 UR - https://www.unboundmedicine.com/medline/citation/18179502/Higher_levels_of_inflammation_factors_and_greater_insulin_resistance_are_independently_associated_with_higher_heart_rate_and_lower_heart_rate_variability_in_normoglycemic_older_individuals:_the_Cardiovascular_Health_Study_ L2 - https://doi.org/10.1111/j.1532-5415.2007.01564.x DB - PRIME DP - Unbound Medicine ER -