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Association between PTPN22 C1858T and type 1 diabetes: a replication in continental Italy.
Tissue Antigens 2008; 71(3):234-7TA

Abstract

The missense PTPN22 C1858T polymorphism recently emerged as an important population-independent risk factor for type 1 diabetes (T1D) and other autoimmune diseases. The PTPN22 gene encodes the lymphoid tyrosine phosphatase (LYP), a negative regulator of signal transduction through the T-cell receptor. Although the frequency of the polymorphism is variable among different ethnic groups, the association between PTPN22 *T1858 and T1D has been replicated in several populations. Here, we contribute the first replication of the association between PTPN22 and T1D in populations from continental Italy, carried out in two independent samples of T1D patients (N = 216 and 82) and controls (N = 271 and 89). Our data also suggest that T1D carriers of the *T1858 allele could be at increased risk for other comorbid autoimmune disorders.

Authors+Show Affiliations

Department of Internal Medicine, Division of Clinical Immunology, University of Rome Tor Vergata, Rome, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18179648

Citation

Saccucci, P, et al. "Association Between PTPN22 C1858T and Type 1 Diabetes: a Replication in Continental Italy." Tissue Antigens, vol. 71, no. 3, 2008, pp. 234-7.
Saccucci P, Del Duca E, Rapini N, et al. Association between PTPN22 C1858T and type 1 diabetes: a replication in continental Italy. Tissue Antigens. 2008;71(3):234-7.
Saccucci, P., Del Duca, E., Rapini, N., Verrotti, A., Piccinini, S., Maccari, A., ... Bottini, N. (2008). Association between PTPN22 C1858T and type 1 diabetes: a replication in continental Italy. Tissue Antigens, 71(3), pp. 234-7. doi:10.1111/j.1399-0039.2007.00987.x.
Saccucci P, et al. Association Between PTPN22 C1858T and Type 1 Diabetes: a Replication in Continental Italy. Tissue Antigens. 2008;71(3):234-7. PubMed PMID: 18179648.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between PTPN22 C1858T and type 1 diabetes: a replication in continental Italy. AU - Saccucci,P, AU - Del Duca,E, AU - Rapini,N, AU - Verrotti,A, AU - Piccinini,S, AU - Maccari,A, AU - Canu,G, AU - Angelini,F, AU - Fontana,L, AU - Giannini,C, AU - Chiarelli,F, AU - Manca Bitti,M L, AU - Bottini,N, Y1 - 2008/01/07/ PY - 2008/1/9/pubmed PY - 2008/5/3/medline PY - 2008/1/9/entrez SP - 234 EP - 7 JF - Tissue antigens JO - Tissue Antigens VL - 71 IS - 3 N2 - The missense PTPN22 C1858T polymorphism recently emerged as an important population-independent risk factor for type 1 diabetes (T1D) and other autoimmune diseases. The PTPN22 gene encodes the lymphoid tyrosine phosphatase (LYP), a negative regulator of signal transduction through the T-cell receptor. Although the frequency of the polymorphism is variable among different ethnic groups, the association between PTPN22 *T1858 and T1D has been replicated in several populations. Here, we contribute the first replication of the association between PTPN22 and T1D in populations from continental Italy, carried out in two independent samples of T1D patients (N = 216 and 82) and controls (N = 271 and 89). Our data also suggest that T1D carriers of the *T1858 allele could be at increased risk for other comorbid autoimmune disorders. SN - 0001-2815 UR - https://www.unboundmedicine.com/medline/citation/18179648/Association_between_PTPN22_C1858T_and_type_1_diabetes:_a_replication_in_continental_Italy_ L2 - https://doi.org/10.1111/j.1399-0039.2007.00987.x DB - PRIME DP - Unbound Medicine ER -