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Influence of apolipoprotein E genotype and dietary alpha-tocopherol on redox status and C-reactive protein levels in apolipoprotein E3 and E4 targeted replacement mice.
Br J Nutr. 2008 Jul; 100(1):44-53.BJ

Abstract

The molecular basis of the positive association between apoE4 genotype and CVD remains unclear. There is direct in vitro evidence indicating that apoE4 is a poorer antioxidant relative to the apoE3 isoform, with some indirect in vivo evidence also available. Therefore it was hypothesised that apoE4 carriers may benefit from alpha-tocopherol (alpha-Toc) supplementation. Targeted replacement mice expressing the human apoE3 and apoE4 were fed with a diet poor (0 mg/kg diet) or rich (200 mg/kg diet) in alpha-Toc for 12 weeks. Neither apoE genotype nor dietary alpha-Toc exerted any effects on the antioxidant defence system, including glutathione, catalase, superoxide dismutase, glutathione peroxidase and glutathione reductase activities. In addition, no differences were observed in mitogen-induced lymphocyte proliferation. alpha-Toc concentrations were modestly higher in plasma and lower in tissues of apoE4 compared with apoE3 mice, with the greatest differences evident in the lung, suggesting that an apoE4 genotype may reduce alpha-Toc delivery to tissues. A tendency towards increased plasma F2-isoprostanes in apoE4 mice was observed, while liver thiobarbituric acid-reactive substances did not differ between apoE3 and apoE4 mice. In addition, C-reactive protein (CRP) concentrations were reduced in apoE4 mice indicating that this positive effect on CRP may in part negate the increased CVD risk associated with an apoE4 genotype.

Authors+Show Affiliations

Institute of Human Nutrition and Food Science, Christian Albrechts University of Kiel, Hermann-Rodewald-Strasse 6, Kiel 24098, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18179727

Citation

Jofre-Monseny, Laia, et al. "Influence of Apolipoprotein E Genotype and Dietary Alpha-tocopherol On Redox Status and C-reactive Protein Levels in Apolipoprotein E3 and E4 Targeted Replacement Mice." The British Journal of Nutrition, vol. 100, no. 1, 2008, pp. 44-53.
Jofre-Monseny L, Huebbe P, Stange I, et al. Influence of apolipoprotein E genotype and dietary alpha-tocopherol on redox status and C-reactive protein levels in apolipoprotein E3 and E4 targeted replacement mice. Br J Nutr. 2008;100(1):44-53.
Jofre-Monseny, L., Huebbe, P., Stange, I., Boesch-Saadatmandi, C., Frank, J., Jackson, K., Minihane, A. M., & Rimbach, G. (2008). Influence of apolipoprotein E genotype and dietary alpha-tocopherol on redox status and C-reactive protein levels in apolipoprotein E3 and E4 targeted replacement mice. The British Journal of Nutrition, 100(1), 44-53. https://doi.org/10.1017/S000711450788634X
Jofre-Monseny L, et al. Influence of Apolipoprotein E Genotype and Dietary Alpha-tocopherol On Redox Status and C-reactive Protein Levels in Apolipoprotein E3 and E4 Targeted Replacement Mice. Br J Nutr. 2008;100(1):44-53. PubMed PMID: 18179727.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of apolipoprotein E genotype and dietary alpha-tocopherol on redox status and C-reactive protein levels in apolipoprotein E3 and E4 targeted replacement mice. AU - Jofre-Monseny,Laia, AU - Huebbe,Patricia, AU - Stange,Inken, AU - Boesch-Saadatmandi,Christine, AU - Frank,Jan, AU - Jackson,Kim, AU - Minihane,Anne-Marie, AU - Rimbach,Gerald, Y1 - 2008/01/08/ PY - 2008/1/9/pubmed PY - 2009/1/20/medline PY - 2008/1/9/entrez SP - 44 EP - 53 JF - The British journal of nutrition JO - Br J Nutr VL - 100 IS - 1 N2 - The molecular basis of the positive association between apoE4 genotype and CVD remains unclear. There is direct in vitro evidence indicating that apoE4 is a poorer antioxidant relative to the apoE3 isoform, with some indirect in vivo evidence also available. Therefore it was hypothesised that apoE4 carriers may benefit from alpha-tocopherol (alpha-Toc) supplementation. Targeted replacement mice expressing the human apoE3 and apoE4 were fed with a diet poor (0 mg/kg diet) or rich (200 mg/kg diet) in alpha-Toc for 12 weeks. Neither apoE genotype nor dietary alpha-Toc exerted any effects on the antioxidant defence system, including glutathione, catalase, superoxide dismutase, glutathione peroxidase and glutathione reductase activities. In addition, no differences were observed in mitogen-induced lymphocyte proliferation. alpha-Toc concentrations were modestly higher in plasma and lower in tissues of apoE4 compared with apoE3 mice, with the greatest differences evident in the lung, suggesting that an apoE4 genotype may reduce alpha-Toc delivery to tissues. A tendency towards increased plasma F2-isoprostanes in apoE4 mice was observed, while liver thiobarbituric acid-reactive substances did not differ between apoE3 and apoE4 mice. In addition, C-reactive protein (CRP) concentrations were reduced in apoE4 mice indicating that this positive effect on CRP may in part negate the increased CVD risk associated with an apoE4 genotype. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/18179727/Influence_of_apolipoprotein_E_genotype_and_dietary_alpha_tocopherol_on_redox_status_and_C_reactive_protein_levels_in_apolipoprotein_E3_and_E4_targeted_replacement_mice_ L2 - https://www.cambridge.org/core/product/identifier/S000711450788634X/type/journal_article DB - PRIME DP - Unbound Medicine ER -