Tags

Type your tag names separated by a space and hit enter

Effects of long-term administration of a cocoa polyphenolic extract (Acticoa powder) on cognitive performances in aged rats.
Br J Nutr. 2008 Jul; 100(1):94-101.BJ

Abstract

Numerous studies have indicated that increased vulnerability to oxidative stress may be the main factor involved in functional declines during normal and pathological ageing, and that antioxidant agents, such as polyphenols, may improve or prevent these deficits. We examined whether 1-year administration of a cocoa polyphenolic extract (Acticoa powder), orally delivered at the dose of 24 mg/kg per d between 15 and 27 months of age, affects the onset of age-related cognitive deficits, urinary free dopamine levels and lifespan in old Wistar-Unilever rats. Acticoa powder improved cognitive performances in light extinction and water maze paradigms, increased lifespan and preserved high urinary free dopamine levels. These results suggest that Acticoa powder may be beneficial in retarding age-related brain impairments, including cognitive deficits in normal ageing and perhaps neurodegenerative diseases. Further studies are required to elucidate the mechanisms of cocoa polyphenols in neuroprotection and to explore their effects in man.

Authors+Show Affiliations

ETAP-Applied Ethology, 13 rue du Bois de la Champelle, Vandoeuvre-lès-Nancy 54500, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18179729

Citation

Bisson, Jean-François, et al. "Effects of Long-term Administration of a Cocoa Polyphenolic Extract (Acticoa Powder) On Cognitive Performances in Aged Rats." The British Journal of Nutrition, vol. 100, no. 1, 2008, pp. 94-101.
Bisson JF, Nejdi A, Rozan P, et al. Effects of long-term administration of a cocoa polyphenolic extract (Acticoa powder) on cognitive performances in aged rats. Br J Nutr. 2008;100(1):94-101.
Bisson, J. F., Nejdi, A., Rozan, P., Hidalgo, S., Lalonde, R., & Messaoudi, M. (2008). Effects of long-term administration of a cocoa polyphenolic extract (Acticoa powder) on cognitive performances in aged rats. The British Journal of Nutrition, 100(1), 94-101. https://doi.org/10.1017/S0007114507886375
Bisson JF, et al. Effects of Long-term Administration of a Cocoa Polyphenolic Extract (Acticoa Powder) On Cognitive Performances in Aged Rats. Br J Nutr. 2008;100(1):94-101. PubMed PMID: 18179729.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of long-term administration of a cocoa polyphenolic extract (Acticoa powder) on cognitive performances in aged rats. AU - Bisson,Jean-François, AU - Nejdi,Amine, AU - Rozan,Pascale, AU - Hidalgo,Sophie, AU - Lalonde,Robert, AU - Messaoudi,Michaël, Y1 - 2008/01/08/ PY - 2008/1/9/pubmed PY - 2009/1/20/medline PY - 2008/1/9/entrez SP - 94 EP - 101 JF - The British journal of nutrition JO - Br J Nutr VL - 100 IS - 1 N2 - Numerous studies have indicated that increased vulnerability to oxidative stress may be the main factor involved in functional declines during normal and pathological ageing, and that antioxidant agents, such as polyphenols, may improve or prevent these deficits. We examined whether 1-year administration of a cocoa polyphenolic extract (Acticoa powder), orally delivered at the dose of 24 mg/kg per d between 15 and 27 months of age, affects the onset of age-related cognitive deficits, urinary free dopamine levels and lifespan in old Wistar-Unilever rats. Acticoa powder improved cognitive performances in light extinction and water maze paradigms, increased lifespan and preserved high urinary free dopamine levels. These results suggest that Acticoa powder may be beneficial in retarding age-related brain impairments, including cognitive deficits in normal ageing and perhaps neurodegenerative diseases. Further studies are required to elucidate the mechanisms of cocoa polyphenols in neuroprotection and to explore their effects in man. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/18179729/Effects_of_long_term_administration_of_a_cocoa_polyphenolic_extract__Acticoa_powder__on_cognitive_performances_in_aged_rats_ L2 - https://www.cambridge.org/core/product/identifier/S0007114507886375/type/journal_article DB - PRIME DP - Unbound Medicine ER -