Tags

Type your tag names separated by a space and hit enter

Therapeutic potential of AIF-mediated caspase-independent programmed cell death.
Drug Resist Updat. 2007 Dec; 10(6):235-55.DR

Abstract

Resistance to anticancer drugs is often related to deficient cell death execution pathways in cancer cells. Apoptosis, which denotes a form of cell death executed by caspases, was traditionally considered as the only physiological and programmed form of cell death. However, recent evidence indicates that programmed cell death (PCD) can occur in complete absence of caspase activation. Indeed, a large number of caspase-independent models are now defined and a key protein implicated in this type of PCD, apoptosis-inducing factor (AIF), has been identified. AIF is a mitochondrial protein with two faces looking in opposite life/death directions. Recently, the identification of five different isoforms allowed a better characterization of AIFs life/mitochondrial versus death/nuclear functions, as well as definition of its pro-apoptotic region and some of its nuclear partners. Importantly, much work on caspase-independent PCD has revealed that AIF participates in more PCD systems than initially thought. A wider molecular knowledge of AIF, and of the caspase-independent PCDs in which it is involved, are key to provide new insights into the role of PCD. There is no doubt that these insights will lead to the development of more selective and efficient drugs against cancer, degenerative diseases, and other pathological disorders implicating AIF.

Authors+Show Affiliations

INSERM U542, Institut André Lwoff, Lavoisier Building, 94803 Villejuif, France. lorenzo@vjf.inserm.frNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18180198

Citation

Lorenzo, Hans K., and Santos A. Susin. "Therapeutic Potential of AIF-mediated Caspase-independent Programmed Cell Death." Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy, vol. 10, no. 6, 2007, pp. 235-55.
Lorenzo HK, Susin SA. Therapeutic potential of AIF-mediated caspase-independent programmed cell death. Drug Resist Updat. 2007;10(6):235-55.
Lorenzo, H. K., & Susin, S. A. (2007). Therapeutic potential of AIF-mediated caspase-independent programmed cell death. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy, 10(6), 235-55. https://doi.org/10.1016/j.drup.2007.11.001
Lorenzo HK, Susin SA. Therapeutic Potential of AIF-mediated Caspase-independent Programmed Cell Death. Drug Resist Updat. 2007;10(6):235-55. PubMed PMID: 18180198.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Therapeutic potential of AIF-mediated caspase-independent programmed cell death. AU - Lorenzo,Hans K, AU - Susin,Santos A, Y1 - 2008/01/03/ PY - 2007/10/22/received PY - 2007/11/01/accepted PY - 2008/1/9/pubmed PY - 2008/2/15/medline PY - 2008/1/9/entrez SP - 235 EP - 55 JF - Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy JO - Drug Resist Updat VL - 10 IS - 6 N2 - Resistance to anticancer drugs is often related to deficient cell death execution pathways in cancer cells. Apoptosis, which denotes a form of cell death executed by caspases, was traditionally considered as the only physiological and programmed form of cell death. However, recent evidence indicates that programmed cell death (PCD) can occur in complete absence of caspase activation. Indeed, a large number of caspase-independent models are now defined and a key protein implicated in this type of PCD, apoptosis-inducing factor (AIF), has been identified. AIF is a mitochondrial protein with two faces looking in opposite life/death directions. Recently, the identification of five different isoforms allowed a better characterization of AIFs life/mitochondrial versus death/nuclear functions, as well as definition of its pro-apoptotic region and some of its nuclear partners. Importantly, much work on caspase-independent PCD has revealed that AIF participates in more PCD systems than initially thought. A wider molecular knowledge of AIF, and of the caspase-independent PCDs in which it is involved, are key to provide new insights into the role of PCD. There is no doubt that these insights will lead to the development of more selective and efficient drugs against cancer, degenerative diseases, and other pathological disorders implicating AIF. SN - 1532-2084 UR - https://www.unboundmedicine.com/medline/citation/18180198/Therapeutic_potential_of_AIF_mediated_caspase_independent_programmed_cell_death_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1368-7646(07)00074-X DB - PRIME DP - Unbound Medicine ER -