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Effects of aspirin and propranolol on the acute psychological stress response in factor VIII coagulant activity: a randomized, double-blind, placebo-controlled experimental study.
Blood Coagul Fibrinolysis. 2008 Jan; 19(1):75-81.BC

Abstract

Activity of clotting factor VIII has been shown to acutely increase with sympathetic nervous system stimulation. We investigated whether aspirin and propranolol affect the responsiveness of plasma clotting factor VIII activity levels to acute psychosocial stress. We randomized 54 healthy subjects double-blind to 5-day treatment with a single daily oral dosage of either 100 mg aspirin plus 80 mg propranolol combined, 100 mg of aspirin, 80 mg of propranolol, or placebo medication. Thereafter, subjects underwent a 13-min standardized psychosocial stressor. Plasma levels of clotting factor VIII activity were determined immediately before, immediately after, 45 min and 105 min after stress. Controlling for demographic, metabolic, and life style factors repeated measures analysis of covariance showed that the change in clotting factor VIII activity from prestress to 105 min poststress differed between medication groups (P = 0.023; partial eta = 0.132). The clotting factor VIII activity level decreased from prestress to immediately poststress in the aspirin/propranolol group relative to the placebo group (P = 0.048) and the aspirin group (P < 0.06). Between 45 min and 105 min poststress, clotting factor VIII levels increased in the aspirin/propranolol group relative to the placebo group (P = 0.007) and the aspirin group (P = 0.039). The stress response in clotting factor VIII activity levels was not significantly different between the aspirin/propranolol group and the propranolol group. Propranolol in combination with aspirin diminished the acute response in clotting factor VIII activity to psychosocial stress compared with placebo medication and aspirin alone. The effect of single aspirin on the acute clotting factor VIII stress response was indistinguishable from a placebo effect.

Authors+Show Affiliations

Department of General Internal Medicine, Swiss Cardiovascular Center, University Hospital Berne, Berne, Switzerland. roland.vonkaenel@insel.chNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18180620

Citation

von Känel, Roland, et al. "Effects of Aspirin and Propranolol On the Acute Psychological Stress Response in Factor VIII Coagulant Activity: a Randomized, Double-blind, Placebo-controlled Experimental Study." Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis, vol. 19, no. 1, 2008, pp. 75-81.
von Känel R, Kudielka BM, Helfricht S, et al. Effects of aspirin and propranolol on the acute psychological stress response in factor VIII coagulant activity: a randomized, double-blind, placebo-controlled experimental study. Blood Coagul Fibrinolysis. 2008;19(1):75-81.
von Känel, R., Kudielka, B. M., Helfricht, S., Metzenthin, P., Preckel, D., Haeberli, A., Cung, T., & Fischer, J. E. (2008). Effects of aspirin and propranolol on the acute psychological stress response in factor VIII coagulant activity: a randomized, double-blind, placebo-controlled experimental study. Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis, 19(1), 75-81. https://doi.org/10.1097/MBC.0b013e3282f38c4e
von Känel R, et al. Effects of Aspirin and Propranolol On the Acute Psychological Stress Response in Factor VIII Coagulant Activity: a Randomized, Double-blind, Placebo-controlled Experimental Study. Blood Coagul Fibrinolysis. 2008;19(1):75-81. PubMed PMID: 18180620.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of aspirin and propranolol on the acute psychological stress response in factor VIII coagulant activity: a randomized, double-blind, placebo-controlled experimental study. AU - von Känel,Roland, AU - Kudielka,Brigitte M, AU - Helfricht,Susanne, AU - Metzenthin,Petra, AU - Preckel,Daniel, AU - Haeberli,André, AU - Cung,Trinh, AU - Fischer,Joachim E, PY - 2008/1/9/pubmed PY - 2008/4/1/medline PY - 2008/1/9/entrez SP - 75 EP - 81 JF - Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis JO - Blood Coagul Fibrinolysis VL - 19 IS - 1 N2 - Activity of clotting factor VIII has been shown to acutely increase with sympathetic nervous system stimulation. We investigated whether aspirin and propranolol affect the responsiveness of plasma clotting factor VIII activity levels to acute psychosocial stress. We randomized 54 healthy subjects double-blind to 5-day treatment with a single daily oral dosage of either 100 mg aspirin plus 80 mg propranolol combined, 100 mg of aspirin, 80 mg of propranolol, or placebo medication. Thereafter, subjects underwent a 13-min standardized psychosocial stressor. Plasma levels of clotting factor VIII activity were determined immediately before, immediately after, 45 min and 105 min after stress. Controlling for demographic, metabolic, and life style factors repeated measures analysis of covariance showed that the change in clotting factor VIII activity from prestress to 105 min poststress differed between medication groups (P = 0.023; partial eta = 0.132). The clotting factor VIII activity level decreased from prestress to immediately poststress in the aspirin/propranolol group relative to the placebo group (P = 0.048) and the aspirin group (P < 0.06). Between 45 min and 105 min poststress, clotting factor VIII levels increased in the aspirin/propranolol group relative to the placebo group (P = 0.007) and the aspirin group (P = 0.039). The stress response in clotting factor VIII activity levels was not significantly different between the aspirin/propranolol group and the propranolol group. Propranolol in combination with aspirin diminished the acute response in clotting factor VIII activity to psychosocial stress compared with placebo medication and aspirin alone. The effect of single aspirin on the acute clotting factor VIII stress response was indistinguishable from a placebo effect. SN - 0957-5235 UR - https://www.unboundmedicine.com/medline/citation/18180620/Effects_of_aspirin_and_propranolol_on_the_acute_psychological_stress_response_in_factor_VIII_coagulant_activity:_a_randomized_double_blind_placebo_controlled_experimental_study_ L2 - https://doi.org/10.1097/MBC.0b013e3282f38c4e DB - PRIME DP - Unbound Medicine ER -