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Paracellular and transcellular permeabilities of fosfomycin across small intestinal membrane of rat and rabbit by voltage-clamp method.
J Pharmacobiodyn. 1991 Oct; 14(10):583-9.JP

Abstract

The permeability of fosfomycin (FOM), which is a low molecular weight and water-soluble antibiotic, across rat and rabbit jejunal membrane was investigated on a paracellular route and a transcellular route separated by voltage-clamp method. It was determined that FOM permeates through these two routes in both animals. Under a physiologically normal condition, the transmucosal electrical potential difference (about 2 mV), the contribution of the transcellular route to FOM membrane permeability was greater than that of the paracellular route. The transcellular permeability was significantly reduced in the presence of inorganic phosphate. The inhibitory effects of the inorganic phosphate coincided with our reports on FOM uptake by rat jejunal brush-border membrane vesicles in vitro and on FOM absorption by rat jejunal single-pass perfusion in situ.

Authors+Show Affiliations

Pharmaceutical Research Laboratories, Meiji Seika Kaisha, Ltd., Yokohama, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1818100

Citation

Ishizawa, T, et al. "Paracellular and Transcellular Permeabilities of Fosfomycin Across Small Intestinal Membrane of Rat and Rabbit By Voltage-clamp Method." Journal of Pharmacobio-dynamics, vol. 14, no. 10, 1991, pp. 583-9.
Ishizawa T, Hayashi M, Awazu S. Paracellular and transcellular permeabilities of fosfomycin across small intestinal membrane of rat and rabbit by voltage-clamp method. J Pharmacobiodyn. 1991;14(10):583-9.
Ishizawa, T., Hayashi, M., & Awazu, S. (1991). Paracellular and transcellular permeabilities of fosfomycin across small intestinal membrane of rat and rabbit by voltage-clamp method. Journal of Pharmacobio-dynamics, 14(10), 583-9.
Ishizawa T, Hayashi M, Awazu S. Paracellular and Transcellular Permeabilities of Fosfomycin Across Small Intestinal Membrane of Rat and Rabbit By Voltage-clamp Method. J Pharmacobiodyn. 1991;14(10):583-9. PubMed PMID: 1818100.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Paracellular and transcellular permeabilities of fosfomycin across small intestinal membrane of rat and rabbit by voltage-clamp method. AU - Ishizawa,T, AU - Hayashi,M, AU - Awazu,S, PY - 1991/10/1/pubmed PY - 1991/10/1/medline PY - 1991/10/1/entrez SP - 583 EP - 9 JF - Journal of pharmacobio-dynamics JO - J Pharmacobiodyn VL - 14 IS - 10 N2 - The permeability of fosfomycin (FOM), which is a low molecular weight and water-soluble antibiotic, across rat and rabbit jejunal membrane was investigated on a paracellular route and a transcellular route separated by voltage-clamp method. It was determined that FOM permeates through these two routes in both animals. Under a physiologically normal condition, the transmucosal electrical potential difference (about 2 mV), the contribution of the transcellular route to FOM membrane permeability was greater than that of the paracellular route. The transcellular permeability was significantly reduced in the presence of inorganic phosphate. The inhibitory effects of the inorganic phosphate coincided with our reports on FOM uptake by rat jejunal brush-border membrane vesicles in vitro and on FOM absorption by rat jejunal single-pass perfusion in situ. SN - 0386-846X UR - https://www.unboundmedicine.com/medline/citation/1818100/Paracellular_and_transcellular_permeabilities_of_fosfomycin_across_small_intestinal_membrane_of_rat_and_rabbit_by_voltage_clamp_method_ DB - PRIME DP - Unbound Medicine ER -