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Polymorphic CAG and GGC repeat lengths in the androgen receptor gene and prostate cancer risk: analysis of a Brazilian population.
Cancer Invest. 2008 Feb; 26(1):74-80.CI

Abstract

Variations in transcriptional activity of the androgen receptor (AR) are related to polymorphic CAG and GGC repeats in exon 1 of the AR gene. We investigated the association between CAG and GGC repeat length and the risk of prostate cancer in a case-control study from a Brazilian population. We evaluated 49 patients and 51 healthy controls. DNA was extracted from peripheral leukocytes and the AR gene was analyzed by fragment analysis (GeneMapper software, Applied Biosystems, Foster City, California, USA). CAG and GGC mean lengths were not different between cases and controls. The risk for prostate cancer was higher for CAG repeats < or = 21 (OR = 2.44 [95% CI 1.03-5.81]) as well as for total repeat lengths (CAG + GGC) < or = 37 (OR = 2.46 [95% CI 0.98-6.18]). GGC repeats (< or = 17 and > 17) were not associated with risk for prostate cancer (OR = 1.13 [95% CI 0.47-2.75]). In conclusion, fewer number of CAG repeats and total repeats (CAG + GGC) in the AR gene may be associated with increased risk for prostate cancer.

Authors+Show Affiliations

Division of Urology, Hospital de Clinicas de Porto Alegre and Urology Department, Medicine School, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18181049

Citation

Silva Neto, Brasil, et al. "Polymorphic CAG and GGC Repeat Lengths in the Androgen Receptor Gene and Prostate Cancer Risk: Analysis of a Brazilian Population." Cancer Investigation, vol. 26, no. 1, 2008, pp. 74-80.
Silva Neto B, Koff WJ, Biolchi V, et al. Polymorphic CAG and GGC repeat lengths in the androgen receptor gene and prostate cancer risk: analysis of a Brazilian population. Cancer Invest. 2008;26(1):74-80.
Silva Neto, B., Koff, W. J., Biolchi, V., Brenner, C., Biolo, K. D., Spritzer, P. M., & Brum, I. S. (2008). Polymorphic CAG and GGC repeat lengths in the androgen receptor gene and prostate cancer risk: analysis of a Brazilian population. Cancer Investigation, 26(1), 74-80. https://doi.org/10.1080/07357900701638251
Silva Neto B, et al. Polymorphic CAG and GGC Repeat Lengths in the Androgen Receptor Gene and Prostate Cancer Risk: Analysis of a Brazilian Population. Cancer Invest. 2008;26(1):74-80. PubMed PMID: 18181049.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polymorphic CAG and GGC repeat lengths in the androgen receptor gene and prostate cancer risk: analysis of a Brazilian population. AU - Silva Neto,Brasil, AU - Koff,Walter J, AU - Biolchi,Vanderlei, AU - Brenner,Cleber, AU - Biolo,Karlo D, AU - Spritzer,Poli Mara, AU - Brum,Ilma S, PY - 2008/1/9/pubmed PY - 2008/2/1/medline PY - 2008/1/9/entrez SP - 74 EP - 80 JF - Cancer investigation JO - Cancer Invest. VL - 26 IS - 1 N2 - Variations in transcriptional activity of the androgen receptor (AR) are related to polymorphic CAG and GGC repeats in exon 1 of the AR gene. We investigated the association between CAG and GGC repeat length and the risk of prostate cancer in a case-control study from a Brazilian population. We evaluated 49 patients and 51 healthy controls. DNA was extracted from peripheral leukocytes and the AR gene was analyzed by fragment analysis (GeneMapper software, Applied Biosystems, Foster City, California, USA). CAG and GGC mean lengths were not different between cases and controls. The risk for prostate cancer was higher for CAG repeats < or = 21 (OR = 2.44 [95% CI 1.03-5.81]) as well as for total repeat lengths (CAG + GGC) < or = 37 (OR = 2.46 [95% CI 0.98-6.18]). GGC repeats (< or = 17 and > 17) were not associated with risk for prostate cancer (OR = 1.13 [95% CI 0.47-2.75]). In conclusion, fewer number of CAG repeats and total repeats (CAG + GGC) in the AR gene may be associated with increased risk for prostate cancer. SN - 1532-4192 UR - https://www.unboundmedicine.com/medline/citation/18181049/Polymorphic_CAG_and_GGC_repeat_lengths_in_the_androgen_receptor_gene_and_prostate_cancer_risk:_analysis_of_a_Brazilian_population_ L2 - http://www.tandfonline.com/doi/full/10.1080/07357900701638251 DB - PRIME DP - Unbound Medicine ER -