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Polycystic ovary syndrome and endometrial cancer.
Semin Reprod Med 2008; 26(1):62-71SR

Abstract

An association between polycystic ovary syndrome (PCOS) and endometrial carcinoma was first suggested in 1949. Since then, several studies have been published that appear to support this association, and it is common practice among gynecologists and physicians to prescribe hormonal treatment to reduce this perceived risk, although there is no consensus as to the subgroup of PCOS in whom this is required. The mechanism(s) underlying any association are also unclear, but it is again widely assumed that chronic anovulation, which results in continuous estrogen stimulation of the endometrium unopposed by progesterone, is a major factor. However, obesity, hyperinsulinemia, and hyperandrogenism, which are also features of PCOS, are risk factors for endometrial carcinoma, but it does not necessarily follow that the incidence or mortality from endometrial cancer is increased in women with the syndrome. Potential strategies to prevent endometrial cancer in PCOS women are discussed.

Authors+Show Affiliations

University Department of Obstetrics and Gynaecology, Royal Free and University College Medical School, University College London, London, United Kingdom.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18181084

Citation

Navaratnarajah, Ramesan, et al. "Polycystic Ovary Syndrome and Endometrial Cancer." Seminars in Reproductive Medicine, vol. 26, no. 1, 2008, pp. 62-71.
Navaratnarajah R, Pillay OC, Hardiman P. Polycystic ovary syndrome and endometrial cancer. Semin Reprod Med. 2008;26(1):62-71.
Navaratnarajah, R., Pillay, O. C., & Hardiman, P. (2008). Polycystic ovary syndrome and endometrial cancer. Seminars in Reproductive Medicine, 26(1), pp. 62-71. doi:10.1055/s-2007-992926.
Navaratnarajah R, Pillay OC, Hardiman P. Polycystic Ovary Syndrome and Endometrial Cancer. Semin Reprod Med. 2008;26(1):62-71. PubMed PMID: 18181084.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polycystic ovary syndrome and endometrial cancer. AU - Navaratnarajah,Ramesan, AU - Pillay,Ouma C, AU - Hardiman,Paul, PY - 2008/1/9/pubmed PY - 2008/3/28/medline PY - 2008/1/9/entrez SP - 62 EP - 71 JF - Seminars in reproductive medicine JO - Semin. Reprod. Med. VL - 26 IS - 1 N2 - An association between polycystic ovary syndrome (PCOS) and endometrial carcinoma was first suggested in 1949. Since then, several studies have been published that appear to support this association, and it is common practice among gynecologists and physicians to prescribe hormonal treatment to reduce this perceived risk, although there is no consensus as to the subgroup of PCOS in whom this is required. The mechanism(s) underlying any association are also unclear, but it is again widely assumed that chronic anovulation, which results in continuous estrogen stimulation of the endometrium unopposed by progesterone, is a major factor. However, obesity, hyperinsulinemia, and hyperandrogenism, which are also features of PCOS, are risk factors for endometrial carcinoma, but it does not necessarily follow that the incidence or mortality from endometrial cancer is increased in women with the syndrome. Potential strategies to prevent endometrial cancer in PCOS women are discussed. SN - 1526-8004 UR - https://www.unboundmedicine.com/medline/citation/18181084/Polycystic_ovary_syndrome_and_endometrial_cancer_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-992926 DB - PRIME DP - Unbound Medicine ER -