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Pregnancy complications in women with polycystic ovary syndrome.
Semin Reprod Med 2008; 26(1):72-84SR

Abstract

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. There is an increasing body of evidence indicating that PCOS may have significant implications for pregnancy outcomes and long-term health of a woman and her offspring. Whether or not PCOS itself or the symptoms that coincide with PCOS, like obesity and fertility treatment, are responsible for these increased risks is a continuing matter of debate. Miscarriage rates among women with PCOS are believed to be increased compared with normal fertile women, although supporting evidence is limited. Pregnant women with PCOS experience a higher incidence of perinatal morbidity from gestational diabetes, pregnancy-induced hypertension, and preeclampsia. Their babies are at an increased risk of neonatal complications, such as preterm birth and admission at a neonatal intensive care unit. Pre-pregnancy, antenatal, and intrapartum care should be aimed at reducing these risks. The use of insulin sensitizing drugs to decrease hyperinsulinemic insulin resistance has been proposed during pregnancy to reduce the risk of developing preeclampsia or gestational diabetes. Although metformin appears to be safe, there are too few data from prospective, randomized controlled trials to support treatment during pregnancy.

Authors+Show Affiliations

Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht, Utrecht, The Netherlands. c.m.boomsma@umcutrecht.nl

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18181085

Citation

Boomsma, Carolien M., et al. "Pregnancy Complications in Women With Polycystic Ovary Syndrome." Seminars in Reproductive Medicine, vol. 26, no. 1, 2008, pp. 72-84.
Boomsma CM, Fauser BC, Macklon NS. Pregnancy complications in women with polycystic ovary syndrome. Semin Reprod Med. 2008;26(1):72-84.
Boomsma, C. M., Fauser, B. C., & Macklon, N. S. (2008). Pregnancy complications in women with polycystic ovary syndrome. Seminars in Reproductive Medicine, 26(1), pp. 72-84. doi:10.1055/s-2007-992927.
Boomsma CM, Fauser BC, Macklon NS. Pregnancy Complications in Women With Polycystic Ovary Syndrome. Semin Reprod Med. 2008;26(1):72-84. PubMed PMID: 18181085.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pregnancy complications in women with polycystic ovary syndrome. AU - Boomsma,Carolien M, AU - Fauser,Bart C J M, AU - Macklon,Nick S, PY - 2008/1/9/pubmed PY - 2008/3/28/medline PY - 2008/1/9/entrez SP - 72 EP - 84 JF - Seminars in reproductive medicine JO - Semin. Reprod. Med. VL - 26 IS - 1 N2 - Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. There is an increasing body of evidence indicating that PCOS may have significant implications for pregnancy outcomes and long-term health of a woman and her offspring. Whether or not PCOS itself or the symptoms that coincide with PCOS, like obesity and fertility treatment, are responsible for these increased risks is a continuing matter of debate. Miscarriage rates among women with PCOS are believed to be increased compared with normal fertile women, although supporting evidence is limited. Pregnant women with PCOS experience a higher incidence of perinatal morbidity from gestational diabetes, pregnancy-induced hypertension, and preeclampsia. Their babies are at an increased risk of neonatal complications, such as preterm birth and admission at a neonatal intensive care unit. Pre-pregnancy, antenatal, and intrapartum care should be aimed at reducing these risks. The use of insulin sensitizing drugs to decrease hyperinsulinemic insulin resistance has been proposed during pregnancy to reduce the risk of developing preeclampsia or gestational diabetes. Although metformin appears to be safe, there are too few data from prospective, randomized controlled trials to support treatment during pregnancy. SN - 1526-8004 UR - https://www.unboundmedicine.com/medline/citation/18181085/Pregnancy_complications_in_women_with_polycystic_ovary_syndrome_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-992927 DB - PRIME DP - Unbound Medicine ER -