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Hepatic dysfunction in pediatric scrub typhus: role of liver function test in diagnosis and marker of disease severity.
J Med Assoc Thai 2007; 90(11):2366-9JM

Abstract

OBJECTIVE

Determine the frequency of abnormalities of liver function test in children with scrub typhus and its relation with severity of disease.

MATERIAL AND METHOD

Fifty-four children diagnosed with scrub typhus at Chiang Rai Regional Hospitalfrom January 2004 to December 2005 were studied. The diagnosis of scrub typhus in the present study was based on a single indirect immunofluorescent antibody (IFA) titer against O tsutsugamushi of > or = 1:400 or a four fold or greater rise in IFA titer to at least 1:200. Liver function tests (LFT) were done on the first few days of admission in all patients. Abnormalities of LFT were focused on serum AST, ALT albumin and total bilirubin level. All of the patients were divided into two groups based on the presence or absence of complications.

RESULTS

Fifty-two patients (96.3%) had abnormal LFT. Evaluation of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were detected in 52 (96.3%) and 36 (66.7%) cases, respectively. Hypoalbuminemia and hyperbilirubinemia were detected in 23 (42.6%) and 4 (7.4%) cases, respectively. The higher level of AST, ALT and lower level ofserum albumin correlated significantly with the severity of scrub typhus in children.

CONCLUSION

Hepatic dysfunction is common in children with scrub typhus. Elevation of AST level may be used as a screening test for diagnosis of scrub typhus in areas where rapid diagnostic test is not commercially available. Increased AST, ALT and hypoalbuminemia related with severity of disease.

Authors+Show Affiliations

Pediatric Unit, Chiang Rai Regional Hospital, Chiang Rai, Thailand.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18181321

Citation

Chanta, Chulapong, et al. "Hepatic Dysfunction in Pediatric Scrub Typhus: Role of Liver Function Test in Diagnosis and Marker of Disease Severity." Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, vol. 90, no. 11, 2007, pp. 2366-9.
Chanta C, Triratanapa K, Ratanasirichup P, et al. Hepatic dysfunction in pediatric scrub typhus: role of liver function test in diagnosis and marker of disease severity. J Med Assoc Thai. 2007;90(11):2366-9.
Chanta, C., Triratanapa, K., Ratanasirichup, P., & Mahaprom, W. (2007). Hepatic dysfunction in pediatric scrub typhus: role of liver function test in diagnosis and marker of disease severity. Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, 90(11), pp. 2366-9.
Chanta C, et al. Hepatic Dysfunction in Pediatric Scrub Typhus: Role of Liver Function Test in Diagnosis and Marker of Disease Severity. J Med Assoc Thai. 2007;90(11):2366-9. PubMed PMID: 18181321.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatic dysfunction in pediatric scrub typhus: role of liver function test in diagnosis and marker of disease severity. AU - Chanta,Chulapong, AU - Triratanapa,Krilerk, AU - Ratanasirichup,Preecha, AU - Mahaprom,Warangkana, PY - 2008/1/10/pubmed PY - 2008/1/26/medline PY - 2008/1/10/entrez SP - 2366 EP - 9 JF - Journal of the Medical Association of Thailand = Chotmaihet thangphaet JO - J Med Assoc Thai VL - 90 IS - 11 N2 - OBJECTIVE: Determine the frequency of abnormalities of liver function test in children with scrub typhus and its relation with severity of disease. MATERIAL AND METHOD: Fifty-four children diagnosed with scrub typhus at Chiang Rai Regional Hospitalfrom January 2004 to December 2005 were studied. The diagnosis of scrub typhus in the present study was based on a single indirect immunofluorescent antibody (IFA) titer against O tsutsugamushi of > or = 1:400 or a four fold or greater rise in IFA titer to at least 1:200. Liver function tests (LFT) were done on the first few days of admission in all patients. Abnormalities of LFT were focused on serum AST, ALT albumin and total bilirubin level. All of the patients were divided into two groups based on the presence or absence of complications. RESULTS: Fifty-two patients (96.3%) had abnormal LFT. Evaluation of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were detected in 52 (96.3%) and 36 (66.7%) cases, respectively. Hypoalbuminemia and hyperbilirubinemia were detected in 23 (42.6%) and 4 (7.4%) cases, respectively. The higher level of AST, ALT and lower level ofserum albumin correlated significantly with the severity of scrub typhus in children. CONCLUSION: Hepatic dysfunction is common in children with scrub typhus. Elevation of AST level may be used as a screening test for diagnosis of scrub typhus in areas where rapid diagnostic test is not commercially available. Increased AST, ALT and hypoalbuminemia related with severity of disease. SN - 0125-2208 UR - https://www.unboundmedicine.com/medline/citation/18181321/Hepatic_dysfunction_in_pediatric_scrub_typhus:_role_of_liver_function_test_in_diagnosis_and_marker_of_disease_severity_ L2 - http://www.diseaseinfosearch.org/result/4280 DB - PRIME DP - Unbound Medicine ER -