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Formulation of controlled-release baclofen matrix tablets: influence of some hydrophilic polymers on the release rate and in vitro evaluation.
AAPS PharmSciTech. 2007 Nov 30; 8(4):E100.AP

Abstract

This work aims at investigating different types and levels of hydrophilic matrixing agents, including methylcellulose (MC), sodium alginate (Alg), and sodium carboxymethylcellulose (CMC), in an attempt to formulate controlled-release matrix tablets containing 25 mg baclofen. The tablets were prepared by wet granulation. Prior to compression, the prepared granules were evaluated for flow and compression characteristics. In vitro, newly formulated controlled-release tablets were compared with standard commercial tablets (Lioresal and baclofen). The excipients used in this study did not alter physicochemical properties of the drug, as tested by the thermal analysis using differential scanning calorimetry. The flow and compression characteristics of the prepared granules significantly improved by virtue of granulation process. Also, the prepared matrix tablets showed good mechanical properties (hardness and friability). MC- and Alg-based tablet formulations showed high release-retarding efficiency, and good reproducibility and stability of the drug release profiles when stored for 6 months in ambient room conditions, suggesting that MC and Alg are good candidates for preparing modified-release baclofen tablet formulations.

Authors+Show Affiliations

Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt. hamdy2002m@yahoo.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18181521

Citation

Abdelkader, Hamdy, et al. "Formulation of Controlled-release Baclofen Matrix Tablets: Influence of some Hydrophilic Polymers On the Release Rate and in Vitro Evaluation." AAPS PharmSciTech, vol. 8, no. 4, 2007, pp. E100.
Abdelkader H, Abdalla OY, Salem H. Formulation of controlled-release baclofen matrix tablets: influence of some hydrophilic polymers on the release rate and in vitro evaluation. AAPS PharmSciTech. 2007;8(4):E100.
Abdelkader, H., Abdalla, O. Y., & Salem, H. (2007). Formulation of controlled-release baclofen matrix tablets: influence of some hydrophilic polymers on the release rate and in vitro evaluation. AAPS PharmSciTech, 8(4), E100. https://doi.org/10.1208/pt0804100
Abdelkader H, Abdalla OY, Salem H. Formulation of Controlled-release Baclofen Matrix Tablets: Influence of some Hydrophilic Polymers On the Release Rate and in Vitro Evaluation. AAPS PharmSciTech. 2007 Nov 30;8(4):E100. PubMed PMID: 18181521.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Formulation of controlled-release baclofen matrix tablets: influence of some hydrophilic polymers on the release rate and in vitro evaluation. AU - Abdelkader,Hamdy, AU - Abdalla,Ossama Youssef, AU - Salem,Hesham, Y1 - 2007/11/30/ PY - 2008/1/10/pubmed PY - 2008/1/25/medline PY - 2008/1/10/entrez SP - E100 EP - E100 JF - AAPS PharmSciTech JO - AAPS PharmSciTech VL - 8 IS - 4 N2 - This work aims at investigating different types and levels of hydrophilic matrixing agents, including methylcellulose (MC), sodium alginate (Alg), and sodium carboxymethylcellulose (CMC), in an attempt to formulate controlled-release matrix tablets containing 25 mg baclofen. The tablets were prepared by wet granulation. Prior to compression, the prepared granules were evaluated for flow and compression characteristics. In vitro, newly formulated controlled-release tablets were compared with standard commercial tablets (Lioresal and baclofen). The excipients used in this study did not alter physicochemical properties of the drug, as tested by the thermal analysis using differential scanning calorimetry. The flow and compression characteristics of the prepared granules significantly improved by virtue of granulation process. Also, the prepared matrix tablets showed good mechanical properties (hardness and friability). MC- and Alg-based tablet formulations showed high release-retarding efficiency, and good reproducibility and stability of the drug release profiles when stored for 6 months in ambient room conditions, suggesting that MC and Alg are good candidates for preparing modified-release baclofen tablet formulations. SN - 1530-9932 UR - https://www.unboundmedicine.com/medline/citation/18181521/Formulation_of_controlled_release_baclofen_matrix_tablets:_influence_of_some_hydrophilic_polymers_on_the_release_rate_and_in_vitro_evaluation_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18181521/ DB - PRIME DP - Unbound Medicine ER -