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Physical mechanical and tablet formation properties of hydroxypropylcellulose: in pure form and in mixtures.
AAPS PharmSciTech. 2007 Nov 09; 8(4):E92.AP

Abstract

The aim of the study was to analyze hydroxypropylcellulose (HPC) in pure form and in excipient mixtures and to relate its physical and chemical properties to tablet binder functionality. The materials used were Klucel hydroxypropylcellulose grades ranging from low to high molecular weight (80-1000 kDa) of regular particle size (250 microm mean size) and fine particle size (80 microm mean size). These were compared with microcrystalline cellulose, spray-dried lactose, and dicalcium phosphate dihydrate. Thermal behavior of HPC was analyzed by modulated temperature differential scanning calorimetry (MTDSC). Tablets of the pure materials and of dry blends with 4% low viscosity, fine particle HPC and 30% high viscosity, fine particle HPC were produced on an instrumented eccentric tableting machine at 3 relative humidities. The 3-dimensional (3-D) model with the parameters time plasticity d, pressure plasticity e, and the twisting angle omega, the inverse of fast elastic decompression was compared with the Heckel method for characterization of compaction. Elastic recovery and compactibility were also studied. The results show that HPC tablet formation is characterized by high plastic deformation. The d, e, and omega values were markedly higher as compared with the reference materials. Plasticity was highest for the fine particle size HPC types. Maximum compactibility was observed for low molecular weight, fine particle size HPC. Tableting of the mixtures showed deformation, which was strongly influenced by HPC. Plasticity and crushing force of formed tablets was increased. In conclusion, HPC is characterized by strong plastic deformation properties, which are molecular weight and particle size dependent.

Authors+Show Affiliations

Martin-Luther-University Halle-Wittenberg, Institute of Pharmaceutics and Biopharmaceutics, Wolfgang-Langenbeck-Str 4, 06120 Halle/Saale, Germany. katharina.picker-freyer@pharmazie.uni-halle.deNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18181552

Citation

Picker-Freyer, Katharina M., and Thomas Dürig. "Physical Mechanical and Tablet Formation Properties of Hydroxypropylcellulose: in Pure Form and in Mixtures." AAPS PharmSciTech, vol. 8, no. 4, 2007, pp. E92.
Picker-Freyer KM, Dürig T. Physical mechanical and tablet formation properties of hydroxypropylcellulose: in pure form and in mixtures. AAPS PharmSciTech. 2007;8(4):E92.
Picker-Freyer, K. M., & Dürig, T. (2007). Physical mechanical and tablet formation properties of hydroxypropylcellulose: in pure form and in mixtures. AAPS PharmSciTech, 8(4), E92. https://doi.org/10.1208/pt0804092
Picker-Freyer KM, Dürig T. Physical Mechanical and Tablet Formation Properties of Hydroxypropylcellulose: in Pure Form and in Mixtures. AAPS PharmSciTech. 2007 Nov 9;8(4):E92. PubMed PMID: 18181552.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Physical mechanical and tablet formation properties of hydroxypropylcellulose: in pure form and in mixtures. AU - Picker-Freyer,Katharina M, AU - Dürig,Thomas, Y1 - 2007/11/09/ PY - 2008/1/10/pubmed PY - 2008/1/25/medline PY - 2008/1/10/entrez SP - E92 EP - E92 JF - AAPS PharmSciTech JO - AAPS PharmSciTech VL - 8 IS - 4 N2 - The aim of the study was to analyze hydroxypropylcellulose (HPC) in pure form and in excipient mixtures and to relate its physical and chemical properties to tablet binder functionality. The materials used were Klucel hydroxypropylcellulose grades ranging from low to high molecular weight (80-1000 kDa) of regular particle size (250 microm mean size) and fine particle size (80 microm mean size). These were compared with microcrystalline cellulose, spray-dried lactose, and dicalcium phosphate dihydrate. Thermal behavior of HPC was analyzed by modulated temperature differential scanning calorimetry (MTDSC). Tablets of the pure materials and of dry blends with 4% low viscosity, fine particle HPC and 30% high viscosity, fine particle HPC were produced on an instrumented eccentric tableting machine at 3 relative humidities. The 3-dimensional (3-D) model with the parameters time plasticity d, pressure plasticity e, and the twisting angle omega, the inverse of fast elastic decompression was compared with the Heckel method for characterization of compaction. Elastic recovery and compactibility were also studied. The results show that HPC tablet formation is characterized by high plastic deformation. The d, e, and omega values were markedly higher as compared with the reference materials. Plasticity was highest for the fine particle size HPC types. Maximum compactibility was observed for low molecular weight, fine particle size HPC. Tableting of the mixtures showed deformation, which was strongly influenced by HPC. Plasticity and crushing force of formed tablets was increased. In conclusion, HPC is characterized by strong plastic deformation properties, which are molecular weight and particle size dependent. SN - 1530-9932 UR - https://www.unboundmedicine.com/medline/citation/18181552/Physical_mechanical_and_tablet_formation_properties_of_hydroxypropylcellulose:_in_pure_form_and_in_mixtures_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18181552/ DB - PRIME DP - Unbound Medicine ER -