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Use of hydrogel coating to improve the performance of implanted glucose sensors.
Biosens Bioelectron. 2008 Mar 14; 23(8):1278-84.BB

Abstract

In order to protect implanted glucose sensors from biofouling, novel hydrogels (146-217% water by mass) were developed based on a copolymer of hydroxyethyl methacrylate (HEMA) and 2,3-dihydroxypropyl methacrylate (DHPMA). The porosity and mechanical properties of the hydrogels were improved using N-vinyl-2-pyrrolidinone (VP) and ethyleneglycol dimethacrylate (EGDMA). The results of SEM and DSC FT-IT analyses showed that the hydrogel (VP30) produced from a monomeric mixture of 34.5% HEMA, 34.5% DHPMA, 30% VP and 1% EDGMA (mol%) had an excellent pore structure, high water content at swelling equilibrium (W eq=166% by mass) and acceptable mechanical properties. Two kinds of VP30-coated sensors, Pt/GOx/VP30 and Pt/GOx/epoxy-polyurethane (EPU)/VP30 sensors were examined in glucose solutions during a period of 4 weeks. The Pt/GOx/VP30 sensors produced large response currents but the response linearity was poor. Therefore, further studies were focused on the Pt/GOx/EPU/VP30 sensors. With a diffusion-limiting epoxy-polyurethane membrane, the linearity was improved (2-30 mM) and the response time was within 5 min. Eight Pt/GOx/EPU/VP30 sensors were subcutaneously implanted in rats and tested once per week over 4 weeks. All of the implanted sensors kept functioning for at least 21 days and 3 out of 8 sensors still functioned at day 28. Histology revealed that the fibrous capsules surrounding hydrogel-coated sensors were thinner than those surrounding Pt/GOx/EPU sensors after 28 days of implantation.

Authors+Show Affiliations

Department of Chemical Engineering, University of South Florida, 4202 E. Fowler Avenue, ENB 118, Tampa, FL 33620-5350, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18182283

Citation

Yu, Bazhang, et al. "Use of Hydrogel Coating to Improve the Performance of Implanted Glucose Sensors." Biosensors & Bioelectronics, vol. 23, no. 8, 2008, pp. 1278-84.
Yu B, Wang C, Ju YM, et al. Use of hydrogel coating to improve the performance of implanted glucose sensors. Biosens Bioelectron. 2008;23(8):1278-84.
Yu, B., Wang, C., Ju, Y. M., West, L., Harmon, J., Moussy, Y., & Moussy, F. (2008). Use of hydrogel coating to improve the performance of implanted glucose sensors. Biosensors & Bioelectronics, 23(8), 1278-84. https://doi.org/10.1016/j.bios.2007.11.010
Yu B, et al. Use of Hydrogel Coating to Improve the Performance of Implanted Glucose Sensors. Biosens Bioelectron. 2008 Mar 14;23(8):1278-84. PubMed PMID: 18182283.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of hydrogel coating to improve the performance of implanted glucose sensors. AU - Yu,Bazhang, AU - Wang,Chunyan, AU - Ju,Young Min, AU - West,Leigh, AU - Harmon,Julie, AU - Moussy,Yvonne, AU - Moussy,Francis, Y1 - 2007/11/29/ PY - 2007/08/24/received PY - 2007/10/30/revised PY - 2007/11/21/accepted PY - 2008/1/10/pubmed PY - 2008/5/30/medline PY - 2008/1/10/entrez SP - 1278 EP - 84 JF - Biosensors & bioelectronics JO - Biosens Bioelectron VL - 23 IS - 8 N2 - In order to protect implanted glucose sensors from biofouling, novel hydrogels (146-217% water by mass) were developed based on a copolymer of hydroxyethyl methacrylate (HEMA) and 2,3-dihydroxypropyl methacrylate (DHPMA). The porosity and mechanical properties of the hydrogels were improved using N-vinyl-2-pyrrolidinone (VP) and ethyleneglycol dimethacrylate (EGDMA). The results of SEM and DSC FT-IT analyses showed that the hydrogel (VP30) produced from a monomeric mixture of 34.5% HEMA, 34.5% DHPMA, 30% VP and 1% EDGMA (mol%) had an excellent pore structure, high water content at swelling equilibrium (W eq=166% by mass) and acceptable mechanical properties. Two kinds of VP30-coated sensors, Pt/GOx/VP30 and Pt/GOx/epoxy-polyurethane (EPU)/VP30 sensors were examined in glucose solutions during a period of 4 weeks. The Pt/GOx/VP30 sensors produced large response currents but the response linearity was poor. Therefore, further studies were focused on the Pt/GOx/EPU/VP30 sensors. With a diffusion-limiting epoxy-polyurethane membrane, the linearity was improved (2-30 mM) and the response time was within 5 min. Eight Pt/GOx/EPU/VP30 sensors were subcutaneously implanted in rats and tested once per week over 4 weeks. All of the implanted sensors kept functioning for at least 21 days and 3 out of 8 sensors still functioned at day 28. Histology revealed that the fibrous capsules surrounding hydrogel-coated sensors were thinner than those surrounding Pt/GOx/EPU sensors after 28 days of implantation. SN - 0956-5663 UR - https://www.unboundmedicine.com/medline/citation/18182283/Use_of_hydrogel_coating_to_improve_the_performance_of_implanted_glucose_sensors_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0956-5663(07)00480-0 DB - PRIME DP - Unbound Medicine ER -