Tags

Type your tag names separated by a space and hit enter

Review on the APP/PS1KI mouse model: intraneuronal Abeta accumulation triggers axonopathy, neuron loss and working memory impairment.
Genes Brain Behav 2008; 7 Suppl 1:6-11GB

Abstract

Accumulating evidence points to an important role of intraneuronal Abeta as a trigger of the pathological cascade of events leading to neurodegeneration and eventually to Alzheimer's disease (AD) with its typical clinical symptoms, like memory impairment and change in personality. As a new concept, intraneuronal accumulation of Abeta instead of extracellular Abeta deposition has been introduced to be the disease-triggering event in AD. The present review compiles current knowledge on the amyloid precursor protein (APP)/PS1KI mouse model with early and massive intraneuronal Abeta42 accumulation: (1) The APP/PS1KI mouse model exhibits early robust brain and spinal cord axonal degeneration and hippocampal CA1 neuron loss. (2) At the same time-point, a dramatic, age-dependent reduced ability to perform working memory and motor tasks is observed. (3) The APP/PS1KI mice are smaller and show development of a thoracolumbar kyphosis, together with an incremental loss of body weight. (4) Onset of the observed behavioral alterations correlates well with robust axonal degeneration in brain and spinal cord and with abundant hippocampal CA1 neuron loss.

Authors+Show Affiliations

Division of Molecular Psychiatry, Department of Psychiatry, University of Goettingen, Goettingen, Germany. tbayer@uni-goettingen.deNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18184366

Citation

Bayer, T A., and O Wirths. "Review On the APP/PS1KI Mouse Model: Intraneuronal Abeta Accumulation Triggers Axonopathy, Neuron Loss and Working Memory Impairment." Genes, Brain, and Behavior, vol. 7 Suppl 1, 2008, pp. 6-11.
Bayer TA, Wirths O. Review on the APP/PS1KI mouse model: intraneuronal Abeta accumulation triggers axonopathy, neuron loss and working memory impairment. Genes Brain Behav. 2008;7 Suppl 1:6-11.
Bayer, T. A., & Wirths, O. (2008). Review on the APP/PS1KI mouse model: intraneuronal Abeta accumulation triggers axonopathy, neuron loss and working memory impairment. Genes, Brain, and Behavior, 7 Suppl 1, pp. 6-11. doi:10.1111/j.1601-183X.2007.00372.x.
Bayer TA, Wirths O. Review On the APP/PS1KI Mouse Model: Intraneuronal Abeta Accumulation Triggers Axonopathy, Neuron Loss and Working Memory Impairment. Genes Brain Behav. 2008;7 Suppl 1:6-11. PubMed PMID: 18184366.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Review on the APP/PS1KI mouse model: intraneuronal Abeta accumulation triggers axonopathy, neuron loss and working memory impairment. AU - Bayer,T A, AU - Wirths,O, PY - 2008/2/8/pubmed PY - 2008/3/13/medline PY - 2008/2/8/entrez SP - 6 EP - 11 JF - Genes, brain, and behavior JO - Genes Brain Behav. VL - 7 Suppl 1 N2 - Accumulating evidence points to an important role of intraneuronal Abeta as a trigger of the pathological cascade of events leading to neurodegeneration and eventually to Alzheimer's disease (AD) with its typical clinical symptoms, like memory impairment and change in personality. As a new concept, intraneuronal accumulation of Abeta instead of extracellular Abeta deposition has been introduced to be the disease-triggering event in AD. The present review compiles current knowledge on the amyloid precursor protein (APP)/PS1KI mouse model with early and massive intraneuronal Abeta42 accumulation: (1) The APP/PS1KI mouse model exhibits early robust brain and spinal cord axonal degeneration and hippocampal CA1 neuron loss. (2) At the same time-point, a dramatic, age-dependent reduced ability to perform working memory and motor tasks is observed. (3) The APP/PS1KI mice are smaller and show development of a thoracolumbar kyphosis, together with an incremental loss of body weight. (4) Onset of the observed behavioral alterations correlates well with robust axonal degeneration in brain and spinal cord and with abundant hippocampal CA1 neuron loss. SN - 1601-183X UR - https://www.unboundmedicine.com/medline/citation/18184366/Review_on_the_APP/PS1KI_mouse_model:_intraneuronal_Abeta_accumulation_triggers_axonopathy_neuron_loss_and_working_memory_impairment_ L2 - https://doi.org/10.1111/j.1601-183X.2007.00372.x DB - PRIME DP - Unbound Medicine ER -