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Diet-induced central obesity and insulin resistance in rabbits.

Abstract

The present study was designed to examine whether rabbits fed a diet containing high fat and sucrose could develop obesity and insulin resistance (IR), the major pathophysiological features of metabolic syndrome. Male Japanese white rabbits were fed either a normal chow diet (control) or high fat and sucrose diet (HFSD) for 36 weeks. Plasma levels of triglycerides (TG), total cholesterol (TC), glucose and insulin were measured. To evaluate glucose metabolism, we performed an intravenous glucose tolerance test. In addition, we compared adipose tissue accumulation in HFSD-fed rabbits with that in normal rabbits. HFSD constantly and significantly led to an increase in body weight of HFSD-fed rabbits, caused by significantly higher visceral adipose tissue accumulation. Although there were no differences in plasma TG, TC, glucose, insulin levels and blood pressure between the two groups, HFSD-fed rabbits showed impaired glucose clearance associated with higher levels of insulin secretion compared to control rabbits. Our results showed that HFSD induced IR and increased adipose accumulation in rabbits, suggesting that HFSD-fed rabbits may become a model for research on human IR and obesity.

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  • Authors+Show Affiliations

    ,

    Laboratory Animal Center, Xi'an Jiaotong University School of Medicine, Xi'an, China.

    , , , , , ,

    Source

    MeSH

    Animals
    Area Under Curve
    Blood Glucose
    Cholesterol
    Diet
    Dietary Fats
    Dietary Sucrose
    Disease Models, Animal
    Glucose Tolerance Test
    Insulin
    Insulin Resistance
    Intra-Abdominal Fat
    Male
    Metabolic Syndrome
    Obesity
    Rabbits
    Triglycerides

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    18184386

    Citation

    Zhao, S, et al. "Diet-induced Central Obesity and Insulin Resistance in Rabbits." Journal of Animal Physiology and Animal Nutrition, vol. 92, no. 1, 2008, pp. 105-11.
    Zhao S, Chu Y, Zhang C, et al. Diet-induced central obesity and insulin resistance in rabbits. J Anim Physiol Anim Nutr (Berl). 2008;92(1):105-11.
    Zhao, S., Chu, Y., Zhang, C., Lin, Y., Xu, K., Yang, P., ... Liu, E. (2008). Diet-induced central obesity and insulin resistance in rabbits. Journal of Animal Physiology and Animal Nutrition, 92(1), pp. 105-11. doi:10.1111/j.1439-0396.2007.00723.x.
    Zhao S, et al. Diet-induced Central Obesity and Insulin Resistance in Rabbits. J Anim Physiol Anim Nutr (Berl). 2008;92(1):105-11. PubMed PMID: 18184386.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Diet-induced central obesity and insulin resistance in rabbits. AU - Zhao,S, AU - Chu,Y, AU - Zhang,C, AU - Lin,Y, AU - Xu,K, AU - Yang,P, AU - Fan,J, AU - Liu,E, PY - 2008/1/11/pubmed PY - 2008/3/18/medline PY - 2008/1/11/entrez SP - 105 EP - 11 JF - Journal of animal physiology and animal nutrition JO - J Anim Physiol Anim Nutr (Berl) VL - 92 IS - 1 N2 - The present study was designed to examine whether rabbits fed a diet containing high fat and sucrose could develop obesity and insulin resistance (IR), the major pathophysiological features of metabolic syndrome. Male Japanese white rabbits were fed either a normal chow diet (control) or high fat and sucrose diet (HFSD) for 36 weeks. Plasma levels of triglycerides (TG), total cholesterol (TC), glucose and insulin were measured. To evaluate glucose metabolism, we performed an intravenous glucose tolerance test. In addition, we compared adipose tissue accumulation in HFSD-fed rabbits with that in normal rabbits. HFSD constantly and significantly led to an increase in body weight of HFSD-fed rabbits, caused by significantly higher visceral adipose tissue accumulation. Although there were no differences in plasma TG, TC, glucose, insulin levels and blood pressure between the two groups, HFSD-fed rabbits showed impaired glucose clearance associated with higher levels of insulin secretion compared to control rabbits. Our results showed that HFSD induced IR and increased adipose accumulation in rabbits, suggesting that HFSD-fed rabbits may become a model for research on human IR and obesity. SN - 1439-0396 UR - https://www.unboundmedicine.com/medline/citation/18184386/Diet_induced_central_obesity_and_insulin_resistance_in_rabbits_ L2 - https://doi.org/10.1111/j.1439-0396.2007.00723.x DB - PRIME DP - Unbound Medicine ER -