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[Correlation of interleukin-10-1082G/a single nucleotide polymorphism to the risk of gastric cancer in north China: a case-control study].
Ai Zheng. 2008 Jan; 27(1):35-40.AZ

Abstract

BACKGROUND & OBJECTIVE

The individual genetic susceptibility is important in the development of gastric cancer. The 1082G/A single nucleotide polymorphism (SNP) of interleukin-10 (IL-10), an immune suppressor gene, became a research hot spot in this field. This study was to analyze the distribution of IL-10-1082G/A SNP in a population from northern China, and explore its correlation to the susceptibility to gastric cancer.

METHODS

Blood samples were taken from 983 subjects in a high risk area of gastric cancer and 533 in a low risk area. The genotype of IL-10-1082G/A was analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Serum level of anti-Helicobacter pylori (H. pylori) IgG was measured by enzyme-linked immunosorbent assay. Matched by sex and age, 111 specimens of normal gastric mucosa (NOR), 111 specimens of superficial gastritis (GS), 111 specimens of gastric erosion ulcer (GEU), 111 specimens of atrophic gastritis (AG) and 111 specimens of gastric cancer (GC) were selected to analyze the correlation of IL-10-1082G/A SNP to the susceptibility to gastric cancer.

RESULTS

The detection rates of IL-10-1082 AA, AG, GG genotypes in the 1516 subjects were 88.5%, 10.9% and 0.6%, respectively. There were no differences in region and sex distribution of IL-10-1082AG+GG genotype between the high and low risk areas of gastric cancer. The detection rate of IL-10-1082 AG+GG genotype was significantly higher in gastric cancer than in benign lesions and normal mucosa (19.8% vs. 9.7% and 6.3%, P=0.003). As compared with the subjects with IL-10-1082 AA genotype and without H.pylori infection, the subjects with AG+GG genotype and without H.pylori infection [odds ratio (OR)=3.3, 95% confidence interval (CI)=1.3-8.6], the subjects with AA genotype and H.pylori infection (OR=4.3, 95% CI=2.0-9.5) and the subjects with AG+GG genotype and H. pylori infection [OR=2.5, 95% CI=2.1-3.1] had higher susceptibility to gastric cancer, but there was no significant difference between every 2 of the 3 groups (P>0.05).

CONCLUSIONS

The susceptibility to gastric cancer is higher in the subjects with IL-10-1082 AG+GG genotype. There is no synergism between IL-10-1082G/A SNP and H.pylori infection.

Authors+Show Affiliations

Cancer Institute, The First Affiliated Hospital, China Medical University, Shenyang, Liaoning, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

18184461

Citation

Bai, Xue-Lei, et al. "[Correlation of interleukin-10-1082G/a Single Nucleotide Polymorphism to the Risk of Gastric Cancer in North China: a Case-control Study]." Ai Zheng = Aizheng = Chinese Journal of Cancer, vol. 27, no. 1, 2008, pp. 35-40.
Bai XL, Sun LP, Liu J, et al. [Correlation of interleukin-10-1082G/a single nucleotide polymorphism to the risk of gastric cancer in north China: a case-control study]. Ai Zheng. 2008;27(1):35-40.
Bai, X. L., Sun, L. P., Liu, J., Chen, W., Zhang, Y., & Yuan, Y. (2008). [Correlation of interleukin-10-1082G/a single nucleotide polymorphism to the risk of gastric cancer in north China: a case-control study]. Ai Zheng = Aizheng = Chinese Journal of Cancer, 27(1), 35-40.
Bai XL, et al. [Correlation of interleukin-10-1082G/a Single Nucleotide Polymorphism to the Risk of Gastric Cancer in North China: a Case-control Study]. Ai Zheng. 2008;27(1):35-40. PubMed PMID: 18184461.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Correlation of interleukin-10-1082G/a single nucleotide polymorphism to the risk of gastric cancer in north China: a case-control study]. AU - Bai,Xue-Lei, AU - Sun,Li-Ping, AU - Liu,Jin, AU - Chen,Wei, AU - Zhang,Ye, AU - Yuan,Yuan, PY - 2008/1/11/pubmed PY - 2010/6/2/medline PY - 2008/1/11/entrez SP - 35 EP - 40 JF - Ai zheng = Aizheng = Chinese journal of cancer JO - Ai Zheng VL - 27 IS - 1 N2 - BACKGROUND & OBJECTIVE: The individual genetic susceptibility is important in the development of gastric cancer. The 1082G/A single nucleotide polymorphism (SNP) of interleukin-10 (IL-10), an immune suppressor gene, became a research hot spot in this field. This study was to analyze the distribution of IL-10-1082G/A SNP in a population from northern China, and explore its correlation to the susceptibility to gastric cancer. METHODS: Blood samples were taken from 983 subjects in a high risk area of gastric cancer and 533 in a low risk area. The genotype of IL-10-1082G/A was analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Serum level of anti-Helicobacter pylori (H. pylori) IgG was measured by enzyme-linked immunosorbent assay. Matched by sex and age, 111 specimens of normal gastric mucosa (NOR), 111 specimens of superficial gastritis (GS), 111 specimens of gastric erosion ulcer (GEU), 111 specimens of atrophic gastritis (AG) and 111 specimens of gastric cancer (GC) were selected to analyze the correlation of IL-10-1082G/A SNP to the susceptibility to gastric cancer. RESULTS: The detection rates of IL-10-1082 AA, AG, GG genotypes in the 1516 subjects were 88.5%, 10.9% and 0.6%, respectively. There were no differences in region and sex distribution of IL-10-1082AG+GG genotype between the high and low risk areas of gastric cancer. The detection rate of IL-10-1082 AG+GG genotype was significantly higher in gastric cancer than in benign lesions and normal mucosa (19.8% vs. 9.7% and 6.3%, P=0.003). As compared with the subjects with IL-10-1082 AA genotype and without H.pylori infection, the subjects with AG+GG genotype and without H.pylori infection [odds ratio (OR)=3.3, 95% confidence interval (CI)=1.3-8.6], the subjects with AA genotype and H.pylori infection (OR=4.3, 95% CI=2.0-9.5) and the subjects with AG+GG genotype and H. pylori infection [OR=2.5, 95% CI=2.1-3.1] had higher susceptibility to gastric cancer, but there was no significant difference between every 2 of the 3 groups (P>0.05). CONCLUSIONS: The susceptibility to gastric cancer is higher in the subjects with IL-10-1082 AG+GG genotype. There is no synergism between IL-10-1082G/A SNP and H.pylori infection. UR - https://www.unboundmedicine.com/medline/citation/18184461/[Correlation_of_interleukin_10_1082G/a_single_nucleotide_polymorphism_to_the_risk_of_gastric_cancer_in_north_China:_a_case_control_study]_ L2 - http://www.cancercommun.com/fulltextnew.asp?y=2008&m=1&ym=35 DB - PRIME DP - Unbound Medicine ER -