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Modified alternate-day fasting regimens reduce cell proliferation rates to a similar extent as daily calorie restriction in mice.
FASEB J. 2008 Jun; 22(6):2090-6.FJ

Abstract

Calorie restriction (CR) and alternate-day fasting (ADF) reduce cancer risk and reduce cell proliferation rates. Whether modified ADF regimens (i.e., allowing a portion of energy needs to be consumed on the fast day) work, as well as true ADF or CR to reduce global cell proliferation rates, remains unresolved. Here, we measured the effects of true ADF, modified ADF, and daily CR on cell proliferation rates in mice. Thirty female C57BL/6J mice were randomized to one of five interventions for 4 wk: 1) CR-25% (25% reduction in daily energy intake), 2) ADF-75% (75% reduction on fast day), 3) ADF-85% (85% reduction on fast day), 4) ADF-100% (100% reduction on fast day), and 5) control (ad libitum intake). Body weights of the ADF groups did not differ from controls, whereas the CR-25% group weighed less than all other groups posttreatment. Epidermal cell proliferation decreased (P<0.01) by 29, 20, and 31% in the CR-25%, ADF-85% and ADF-100% groups, respectively, relative to controls. Proliferation rates of splenic T cells were reduced (P<0.01) by 37, 32, and 31% in the CR-25%, ADF-85%, and ADF-100% groups, respectively, and mammary epithelial cell proliferation was 70, 65, and 62% lower (P<0.01), compared with controls. Insulin-like growth factor-1 levels were reduced (P<0.05) in the CR-25% and ADF-100% groups only. In summary, modified ADF, allowing the consumption of 15% of energy needs on the restricted intake day, decreases global cell proliferation similarly as true ADF and daily CR without reducing body weight.

Authors+Show Affiliations

Department of Nutritional Sciences and Toxicology, University of California at Berkeley, Morgan Hall, Rm. 308, Berkeley, California, 94720-3104, USA. kvarady@nature.berkeley.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18184721

Citation

Varady, K A., et al. "Modified Alternate-day Fasting Regimens Reduce Cell Proliferation Rates to a Similar Extent as Daily Calorie Restriction in Mice." FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, vol. 22, no. 6, 2008, pp. 2090-6.
Varady KA, Roohk DJ, McEvoy-Hein BK, et al. Modified alternate-day fasting regimens reduce cell proliferation rates to a similar extent as daily calorie restriction in mice. FASEB J. 2008;22(6):2090-6.
Varady, K. A., Roohk, D. J., McEvoy-Hein, B. K., Gaylinn, B. D., Thorner, M. O., & Hellerstein, M. K. (2008). Modified alternate-day fasting regimens reduce cell proliferation rates to a similar extent as daily calorie restriction in mice. FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, 22(6), 2090-6. https://doi.org/10.1096/fj.07-098178
Varady KA, et al. Modified Alternate-day Fasting Regimens Reduce Cell Proliferation Rates to a Similar Extent as Daily Calorie Restriction in Mice. FASEB J. 2008;22(6):2090-6. PubMed PMID: 18184721.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modified alternate-day fasting regimens reduce cell proliferation rates to a similar extent as daily calorie restriction in mice. AU - Varady,K A, AU - Roohk,D J, AU - McEvoy-Hein,B K, AU - Gaylinn,B D, AU - Thorner,M O, AU - Hellerstein,M K, Y1 - 2008/01/09/ PY - 2008/1/11/pubmed PY - 2008/7/17/medline PY - 2008/1/11/entrez SP - 2090 EP - 6 JF - FASEB journal : official publication of the Federation of American Societies for Experimental Biology JO - FASEB J VL - 22 IS - 6 N2 - Calorie restriction (CR) and alternate-day fasting (ADF) reduce cancer risk and reduce cell proliferation rates. Whether modified ADF regimens (i.e., allowing a portion of energy needs to be consumed on the fast day) work, as well as true ADF or CR to reduce global cell proliferation rates, remains unresolved. Here, we measured the effects of true ADF, modified ADF, and daily CR on cell proliferation rates in mice. Thirty female C57BL/6J mice were randomized to one of five interventions for 4 wk: 1) CR-25% (25% reduction in daily energy intake), 2) ADF-75% (75% reduction on fast day), 3) ADF-85% (85% reduction on fast day), 4) ADF-100% (100% reduction on fast day), and 5) control (ad libitum intake). Body weights of the ADF groups did not differ from controls, whereas the CR-25% group weighed less than all other groups posttreatment. Epidermal cell proliferation decreased (P<0.01) by 29, 20, and 31% in the CR-25%, ADF-85% and ADF-100% groups, respectively, relative to controls. Proliferation rates of splenic T cells were reduced (P<0.01) by 37, 32, and 31% in the CR-25%, ADF-85%, and ADF-100% groups, respectively, and mammary epithelial cell proliferation was 70, 65, and 62% lower (P<0.01), compared with controls. Insulin-like growth factor-1 levels were reduced (P<0.05) in the CR-25% and ADF-100% groups only. In summary, modified ADF, allowing the consumption of 15% of energy needs on the restricted intake day, decreases global cell proliferation similarly as true ADF and daily CR without reducing body weight. SN - 1530-6860 UR - https://www.unboundmedicine.com/medline/citation/18184721/Modified_alternate_day_fasting_regimens_reduce_cell_proliferation_rates_to_a_similar_extent_as_daily_calorie_restriction_in_mice_ L2 - https://doi.org/10.1096/fj.07-098178 DB - PRIME DP - Unbound Medicine ER -