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Racial disparity in glucagon-like peptide 1 and inflammation markers among severely obese adolescents.
Diabetes Care. 2008 Apr; 31(4):770-5.DC

Abstract

OBJECTIVE

Compared with Caucasians, obese African-American adolescents have a higher risk for type 2 diabetes. Subclinical inflammation and reduced glucagon-like peptide 1 (GLP-1) concentration are linked to the pathogenesis of the disease. We determined the relationship between insulin resistance, beta-cell activity, and subclinical inflammation with GLP-1 concentrations and whether racial disparities in GLP-1 response were present in 49 obese adolescents (14 +/- 3 years; 76% African American; 71% female).

RESEARCH DESIGN AND METHODS

Subjects underwent physical examination and an oral glucose tolerance test. We measured levels of high-sensitivity CRP (CRP(hs)), fibrinogen, glucose, GLP-1(total), GLP-1(active), and insulin. Insulin and glucose area under the curve (AUC), insulinogenic index (DeltaI30/DeltaG30), and composite insulin sensitivity index (CISI) were computed. Subjects were categorized by race and as inflammation positive (INF+) if CRP(hs) or fibrinogen were elevated.

RESULTS

No racial differences were seen in mean or relative BMI. Thirty-five percent of subjects had altered fasting or 2-h glucose levels (African American vs. Caucasian, NS), and 75% were INF+ (African American vs. Caucasian, P = 0.046). Glucose and insulin, CISI, and DeltaI30/DeltaG30 values were similar; African Americans had lower GLP-1(total) AUC (P = 0.01), GLP-1(active) at 15 min (P = 0.03), and GLP-1(active) AUC (P = 0.06) and higher fibrinogen (P = 0.01) and CRP(hs) (NS) compared with Caucasians.

CONCLUSIONS

African Americans exhibited lower GLP-1 concentrations and increased inflammatory response. Both mechanisms may act synergistically to enhance the predisposition of obese African Americans to type 2 diabetes. Our findings might be relevant to effective deployment of emerging GLP-1-based treatments across ethnicities.

Authors+Show Affiliations

Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee, USA. pvelasquez@utmem.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18184905

Citation

Velásquez-Mieyer, Pedro A., et al. "Racial Disparity in Glucagon-like Peptide 1 and Inflammation Markers Among Severely Obese Adolescents." Diabetes Care, vol. 31, no. 4, 2008, pp. 770-5.
Velásquez-Mieyer PA, Cowan PA, Pérez-Faustinelli S, et al. Racial disparity in glucagon-like peptide 1 and inflammation markers among severely obese adolescents. Diabetes Care. 2008;31(4):770-5.
Velásquez-Mieyer, P. A., Cowan, P. A., Pérez-Faustinelli, S., Nieto-Martínez, R., Villegas-Barreto, C., Tolley, E. A., Lustig, R. H., & Alpert, B. S. (2008). Racial disparity in glucagon-like peptide 1 and inflammation markers among severely obese adolescents. Diabetes Care, 31(4), 770-5. https://doi.org/10.2337/dc07-1525
Velásquez-Mieyer PA, et al. Racial Disparity in Glucagon-like Peptide 1 and Inflammation Markers Among Severely Obese Adolescents. Diabetes Care. 2008;31(4):770-5. PubMed PMID: 18184905.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Racial disparity in glucagon-like peptide 1 and inflammation markers among severely obese adolescents. AU - Velásquez-Mieyer,Pedro A, AU - Cowan,Patricia A, AU - Pérez-Faustinelli,Sylvia, AU - Nieto-Martínez,Ramfis, AU - Villegas-Barreto,Cesar, AU - Tolley,Elizabeth A, AU - Lustig,Robert H, AU - Alpert,Bruce S, Y1 - 2008/01/09/ PY - 2008/1/11/pubmed PY - 2008/8/7/medline PY - 2008/1/11/entrez SP - 770 EP - 5 JF - Diabetes care JO - Diabetes Care VL - 31 IS - 4 N2 - OBJECTIVE: Compared with Caucasians, obese African-American adolescents have a higher risk for type 2 diabetes. Subclinical inflammation and reduced glucagon-like peptide 1 (GLP-1) concentration are linked to the pathogenesis of the disease. We determined the relationship between insulin resistance, beta-cell activity, and subclinical inflammation with GLP-1 concentrations and whether racial disparities in GLP-1 response were present in 49 obese adolescents (14 +/- 3 years; 76% African American; 71% female). RESEARCH DESIGN AND METHODS: Subjects underwent physical examination and an oral glucose tolerance test. We measured levels of high-sensitivity CRP (CRP(hs)), fibrinogen, glucose, GLP-1(total), GLP-1(active), and insulin. Insulin and glucose area under the curve (AUC), insulinogenic index (DeltaI30/DeltaG30), and composite insulin sensitivity index (CISI) were computed. Subjects were categorized by race and as inflammation positive (INF+) if CRP(hs) or fibrinogen were elevated. RESULTS: No racial differences were seen in mean or relative BMI. Thirty-five percent of subjects had altered fasting or 2-h glucose levels (African American vs. Caucasian, NS), and 75% were INF+ (African American vs. Caucasian, P = 0.046). Glucose and insulin, CISI, and DeltaI30/DeltaG30 values were similar; African Americans had lower GLP-1(total) AUC (P = 0.01), GLP-1(active) at 15 min (P = 0.03), and GLP-1(active) AUC (P = 0.06) and higher fibrinogen (P = 0.01) and CRP(hs) (NS) compared with Caucasians. CONCLUSIONS: African Americans exhibited lower GLP-1 concentrations and increased inflammatory response. Both mechanisms may act synergistically to enhance the predisposition of obese African Americans to type 2 diabetes. Our findings might be relevant to effective deployment of emerging GLP-1-based treatments across ethnicities. SN - 1935-5548 UR - https://www.unboundmedicine.com/medline/citation/18184905/Racial_disparity_in_glucagon_like_peptide_1_and_inflammation_markers_among_severely_obese_adolescents_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&pmid=18184905 DB - PRIME DP - Unbound Medicine ER -