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[Steroid receptor superfamily and its mechanism of action].
Nihon Rinsho. 2008 Jan; 66(1):9-15.NR

Abstract

Steroid receptors are evoluted from the common ancestor and have the same structure as steroid receptor superfamily. The nuclear receptors are characterized by a central DNA binding domain with specific DNA sequences known as hormone response element, ligand binding domain in the C terminal and N terminal domain with the tissue specificity. Nuclear receptor superfamily is divided into four classes based on the dimerization and DNA binding properties, homodimers as steroid hormone receptor, heterodimers with RXR, homodimers and monomers. Most of orphan receptors fall into the last 2 classes. The coregulators as coactivators and corepressor are determined. The mechanism of action of nuclear receptor on chromatin in the nucleus are clarified precisely from the stand point of the clasters of coregulators and the complex of nuclear receptor and coregulators. The crosstalk of nuclear receptor and peptide hormone signal in the cell is important in the autocrine and paracrine action. Non-genomic action of steroid hormone is also proposed.

Authors+Show Affiliations

Fukuoka Prefectural University.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

jpn

PubMed ID

18186252

Citation

Nawata, Hajime, et al. "[Steroid Receptor Superfamily and Its Mechanism of Action]." Nihon Rinsho. Japanese Journal of Clinical Medicine, vol. 66, no. 1, 2008, pp. 9-15.
Nawata H, Yanase T, Okabe T, et al. [Steroid receptor superfamily and its mechanism of action]. Nihon Rinsho. 2008;66(1):9-15.
Nawata, H., Yanase, T., Okabe, T., & Nomura, M. (2008). [Steroid receptor superfamily and its mechanism of action]. Nihon Rinsho. Japanese Journal of Clinical Medicine, 66(1), 9-15.
Nawata H, et al. [Steroid Receptor Superfamily and Its Mechanism of Action]. Nihon Rinsho. 2008;66(1):9-15. PubMed PMID: 18186252.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Steroid receptor superfamily and its mechanism of action]. AU - Nawata,Hajime, AU - Yanase,Toshihiko, AU - Okabe,Taijiro, AU - Nomura,Masaki, PY - 2008/1/12/pubmed PY - 2008/3/7/medline PY - 2008/1/12/entrez SP - 9 EP - 15 JF - Nihon rinsho. Japanese journal of clinical medicine JO - Nihon Rinsho VL - 66 IS - 1 N2 - Steroid receptors are evoluted from the common ancestor and have the same structure as steroid receptor superfamily. The nuclear receptors are characterized by a central DNA binding domain with specific DNA sequences known as hormone response element, ligand binding domain in the C terminal and N terminal domain with the tissue specificity. Nuclear receptor superfamily is divided into four classes based on the dimerization and DNA binding properties, homodimers as steroid hormone receptor, heterodimers with RXR, homodimers and monomers. Most of orphan receptors fall into the last 2 classes. The coregulators as coactivators and corepressor are determined. The mechanism of action of nuclear receptor on chromatin in the nucleus are clarified precisely from the stand point of the clasters of coregulators and the complex of nuclear receptor and coregulators. The crosstalk of nuclear receptor and peptide hormone signal in the cell is important in the autocrine and paracrine action. Non-genomic action of steroid hormone is also proposed. SN - 0047-1852 UR - https://www.unboundmedicine.com/medline/citation/18186252/[Steroid_receptor_superfamily_and_its_mechanism_of_action]_ DB - PRIME DP - Unbound Medicine ER -
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