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Acupuncture inhibits kainic Acid-induced hippocampal cell death in mice.
J Physiol Sci. 2008 Feb; 58(1):31-8.JP

Abstract

We examined whether acupuncture can reduce both the incidence of seizures and hippocampal cell death using a mouse model of kainic acid (KA)-induced epilepsy. ICR mice were given acupuncture once a day at acupoint HT8 (sobu) bilaterally during 2 days before KA injection. After an intracerebroventricular injection of 0.1 microg of KA, acupuncture treatment was subsequently administered once more (total 3 times), and the degree of seizure was observed for 20 min. Three hours after injection, the survival of neuronal cells and the expressions of c-Fos, c-Jun, and glutamate decarboxylase (GAD)-67 in the CA1 and CA3 were determined using immunohistochemistry and Western blotting techniques. Acupuncture reduced the severity of the KA-induced epileptic seizure and the rate of neural cell death, and it also decreased the expressions of c-Fos and c-Jun induced by KA in the hippocampus. Furthermore, acupuncture increased GAD-67 expressions in the same areas. These results demonstrated that it could inhibit the KA-induced epileptic seizure and hippocampal cell death by increasing GAD-67 expressions.

Authors+Show Affiliations

Acupuncture and Meridian Science Research Center, Kyung Hee University, Seoul, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18186956

Citation

Kim, Seung-Tae, et al. "Acupuncture Inhibits Kainic Acid-induced Hippocampal Cell Death in Mice." The Journal of Physiological Sciences : JPS, vol. 58, no. 1, 2008, pp. 31-8.
Kim ST, Jeon S, Park HJ, et al. Acupuncture inhibits kainic Acid-induced hippocampal cell death in mice. J Physiol Sci. 2008;58(1):31-8.
Kim, S. T., Jeon, S., Park, H. J., Hong, M. S., Jeong, W. B., Kim, J. H., Kim, Y., Lee, H. J., Park, H. J., & Chung, J. H. (2008). Acupuncture inhibits kainic Acid-induced hippocampal cell death in mice. The Journal of Physiological Sciences : JPS, 58(1), 31-8. https://doi.org/10.2170/physiolsci.RP010907
Kim ST, et al. Acupuncture Inhibits Kainic Acid-induced Hippocampal Cell Death in Mice. J Physiol Sci. 2008;58(1):31-8. PubMed PMID: 18186956.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acupuncture inhibits kainic Acid-induced hippocampal cell death in mice. AU - Kim,Seung-Tae, AU - Jeon,Songhee, AU - Park,Hae Jeong, AU - Hong,Mee-Sook, AU - Jeong,Wu Byung, AU - Kim,Jang-Hyun, AU - Kim,Yeonjung, AU - Lee,Hye-Jung, AU - Park,Hi-Joon, AU - Chung,Joo-Ho, Y1 - 2008/01/12/ PY - 2007/11/06/received PY - 2008/01/05/accepted PY - 2008/1/12/pubmed PY - 2008/8/14/medline PY - 2008/1/12/entrez SP - 31 EP - 8 JF - The journal of physiological sciences : JPS JO - J Physiol Sci VL - 58 IS - 1 N2 - We examined whether acupuncture can reduce both the incidence of seizures and hippocampal cell death using a mouse model of kainic acid (KA)-induced epilepsy. ICR mice were given acupuncture once a day at acupoint HT8 (sobu) bilaterally during 2 days before KA injection. After an intracerebroventricular injection of 0.1 microg of KA, acupuncture treatment was subsequently administered once more (total 3 times), and the degree of seizure was observed for 20 min. Three hours after injection, the survival of neuronal cells and the expressions of c-Fos, c-Jun, and glutamate decarboxylase (GAD)-67 in the CA1 and CA3 were determined using immunohistochemistry and Western blotting techniques. Acupuncture reduced the severity of the KA-induced epileptic seizure and the rate of neural cell death, and it also decreased the expressions of c-Fos and c-Jun induced by KA in the hippocampus. Furthermore, acupuncture increased GAD-67 expressions in the same areas. These results demonstrated that it could inhibit the KA-induced epileptic seizure and hippocampal cell death by increasing GAD-67 expressions. SN - 1880-6546 UR - https://www.unboundmedicine.com/medline/citation/18186956/Acupuncture_inhibits_kainic_Acid_induced_hippocampal_cell_death_in_mice_ L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/physiolsci/RP010907?from=PubMed DB - PRIME DP - Unbound Medicine ER -